- Lymphocytes From Patients With Type 1 Diabetes Display a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation An Epigenetic Study in Diabetes
[作者：Miao, F; Smith, DD; Zhang, LX; Min, A; Feng, W; Natarajan, R,期刊：Diabetes, 页码：3189-3198 , 文章类型： Article，,卷期：2008年57-12]
- OBJECTIVE-The complexity of interactions between genes and the environment is a major challenge for type 1 diabetes Studies. Nuclear chromatin is the interface between genetics and environment and the principal carrier o...
- Atrial Natriuretic Peptide Induces Postprandial Lipid Oxidation in Humans
[作者：Birkenfeld, AL; Budziarek, P; Boschmann, M; Moro, C; Adams, F; Franke, G; Berlan, M; Marques, MA; Sweep, FCGJ; Luft, FC; Lafontan, M; Jordan, J,期刊：Diabetes, 页码：3199-3204 , 文章类型： Article，,卷期：2008年57-12]
- OBJECTIVE-Atrial natriuretic peptide (ANP) regulates arterial blood pressure. In addition, ANP has recently been shown to promote human adipose tissue lipolysis through cGMP-mediated hormone-sensitive lipase activation. ...
- Ghrelin Infusion in Humans Induces Acute Insulin Resistance and Lipolysis Independent of Growth Hormone Signaling
[作者：Vestergaard, ET; Gormsen, LC; Jessen, N; Lund, S; Hansen, TK; Moller, N; Jorgensen, JOL,期刊：Diabetes, 页码：3205-3210 , 文章类型： Article，,卷期：2008年57-12]
- OBJECTIVE-Ghrelin is a gut-derived peptide and an endogenous ligand for the growth hormone (GH) secretagogue receptor. Exogenous ghrelin stimulates the release of GH (potently) and adrenocorticotropic hormone (ACTH) (mod...
- Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle
[作者：Nieto-Vazquez, I; Fernandez-Veledo, S; de Alvaro, C; Lorenzo, M,期刊：Diabetes, 页码：3211-3221 , 文章类型： Article，,卷期：2008年57-12]
- OBJECTIVE-Cytokines are elevated in various insulin-resistant states, including type 2 diabetes and obesity, although the contribution of interleukin-6 (IL-6) in the induction of these diseases is controversial.RESEARCH ...
- Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes
[作者：Xie, ZL; Zhang, JH; Wu, JL; Viollet, B; Zou, MH,期刊：Diabetes, 页码：3222-3230 , 文章类型： Article，,卷期：2008年57-12]
- OBJECTIVE-Recent evidence suggests that the AMP-activated protein kinase (AMPK) is an important therapeutic target, for diabetes. The present study was conducted to determine how AMPK activation suppressed tyrosine nitra...
- Evidence That Kidney Function but Not Type 2 Diabetes Determines Retinol-Binding Protein 4 Serum Levels
[作者：Henze, A; Frey, SK; Raila, J; Tepel, M; Scholze, A; Pfeiffer, AFH; Weickert, MO; Spranger, J; Schweigert, FJ,期刊：Diabetes, 页码：3323-3326 , 文章类型： Article，,卷期：2008年57-12]
- OBJECTIVE-It has been Suggested that retinol-binding protein 4 (RBP4) links adiposity, insulin resistance, and type 2 diabetes. However, circulating RBP4 levels are also affected by kidney function. Therefore, the aim of...
- Angiogenesis Associated With Visceral and Subcutaneous Adipose Tissue in Severe Human Obesity
[作者：Ledoux, S; Queguiner, I; Msika, S; Calderari, S; Rufat, P; Gasc, JM; Corvol, P; Larger, E,期刊：Diabetes, 页码：3247-3257 , 文章类型： Article，,卷期：2008年57-12]
- OBJECTIVE-The expansion of adipose tissue is linked to the development of its vasculature. However, the regulation of adipose tissue angiogenesis in humans has not, been extensively studied. Our aim was to compare the an...
- Resistance to High-Fat Diet-Induced Obesity but Exacerbated Insulin Resistance in Mice Overexpressing Preadipocyte Factor-1 (Pref-1) A New Model of Partial Lipodystrophy
[作者：Villena, JA; Choi, CS; Wang, Y; Kim, S; Hwang, YJ; Kim, YB; Cline, G; Shulman, GI; Sul, HS,期刊：Diabetes, 页码：3258-3266 , 文章类型： Article，,卷期：2008年57-12]
- OBJECTIVE-White adipose tissue is a critical regulator of whole-body glucose metabolism. Preadipocyte factor-1 (Pref-1) is a secreted protein that inhibits adipocyte differentiation, both in vitro and in vivo. In this st...
- Lower Metabolic Rate in Individuals Heterozygous for Either a Frameshift or a Functional Missense MC4R Variant
[作者：Krakoff, J; Ma, LJ; Kobes, S; Knowler, WC; Hanson, RL; Bogardus, C; Baier, LJ,期刊：Diabetes, 页码：3267-3272 , 文章类型： Article，,卷期：2008年57-12]
- OBJECTIVE-Humans with functional variants in the melanocortin 4 receptor (MC4R) are obese, hyperpliagic, and hyperinsulinemic but have been reported to have no difference in energy expenditure.RESEARCH DESIGN AND METHODS...
- Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice
[作者：Chen, YG; Scheuplein, F; Osborne, MA; Tsaih, SW; Chapman, HD; Serreze, DV,期刊：Diabetes, 页码：3273-3280 , 文章类型： Article，,卷期：2008年57-12]
- OBJECTIVE-Although the H2(y7) major histocompatibility complex (MHC) provides the primary pathogenic component, the development of T-cell-mediated autoimmune type I diabetes in NOD mice also requires contributions from o...
- Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice
[作者：Suarez-Pinzon, WL; Power, RF; Yan, YH; Wasserfall, C; Atkinson, M; Rabinovitch, A,期刊：Diabetes, 页码：3281-3288 , 文章类型： Article，,卷期：2008年57-12]
- OBJECTIVE-Glucagon-like peptide-1 (GLP-1) and gastrin promote pancreatic beta-cell function, survival, and growth. Here, we investigated whether GLP-1 and gastrin can restore the beta-cell mass and reverse hyperglycemia ...
- Diabetes, Abdominal Adiposity, and Atherogenic Dyslipoproteinemia in Women Compared With Men
[作者：Williams, K; Tchernof, A; Hunt, KJ; Wagenknecht, LE; Haffner, SM; Suiderman, AD,期刊：Diabetes, 页码：3289-3296 , 文章类型： Article，,卷期：2008年57-12]
- OBJECTIVE-TO Understand why atherogenic risk differs more between diabetic and nondiabetic Women than between diabetic and nondiabetic men.RESEARCH DESIGN AND METHODS AND RESULTS-Measures of cardiovascular risk, body com...
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