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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   Coumarin-based drugs: a patent review (2008-present) [作者：Kontogiorgis, C; Detsi, A; Hadjipavlou-Litina, D,期刊：Expert Opinion on Therapeutic Patents, 页码：437-454 , 文章类型： Review，,卷期：2012年22-4] Introduction: Coumarins are a group of plant-derived polyphenolic compounds. They belong to the benzopyrones family and possess a wide variety of cytoprotective and modulatory functions, which may be translated to therap... Evaluation of WO2012003387, Gilead's ASK1 inhibitors [作者：Norman, P,期刊：Expert Opinion on Therapeutic Patents, 页码：455-459 , 文章类型： Article，,卷期：2012年22-4] A small number of novel N-(triazolylthiazol-2-yl) and N-(triazolylthienyl) benzamide and picolinamide derivatives are claimed. The compounds are ASK1 kinase inhibitors among which some have nanomolar potency and are pote... PDE Inhibition and cognition enhancement [作者：Blokland, A; Menniti, FS; Prickaerts, J,期刊：Expert Opinion on Therapeutic Patents, 页码：349-354 , 文章类型： Editorial Material，,卷期：2012年22-4] There has been an increasing interest in the development of phosphodiesterase (PDE) inhibitors for the treatment of cognitive dysfunctions. In this editorial, the mechanism of action of PDEs is briefly described, while t... A patent review of sirtuin activators: an update [作者：Villalba, JM; de Cabo, R; Alcain, FJ,期刊：Expert Opinion on Therapeutic Patents, 页码：355-367 , 文章类型： Review，,卷期：2012年22-4] Introduction: Reversible acetylation is a key post-translational modification of target proteins. Sirtuin deacetylases represent the homolog of the yeast silent information regulator (SIR2). Although seven sirtuins have ... Therapeutic potential of A(2) and A(3) adenosine receptor: a review of novel patented ligands [作者：Federico, S; Spalluto, G,期刊：Expert Opinion on Therapeutic Patents, 页码：369-390 , 文章类型： Review，,卷期：2012年22-4] Introduction: Adenosine exerts its effects by interacting with G-protein coupled receptors (GPCR) namely A(1), A(2A), A(2B) and A(3), respectively. These are involved in several diseases, for example and most importantly... Advances in hepatitis C virus vaccines, part two: advances in hepatitis C virus vaccine formulations and modalities [作者：Roohvand, F; Kossari, N,期刊：Expert Opinion on Therapeutic Patents, 页码：391-415 , 文章类型： Review，,卷期：2012年22-4] Introduction: Developing a vaccine against HCV is an important medical and global priority. Unavailability and potential dangers associated with using attenuated HCV viral particles for vaccine preparation have resulted ... Vitamin D receptor ligands: the impact of crystal structures [作者：Carlberg, C; Molnar, F; Mourino, A,期刊：Expert Opinion on Therapeutic Patents, 页码：417-435 , 文章类型： Review，,卷期：2012年22-4] Introduction: In the past years, the biologically active form of vitamin D(3), 1 alpha, 25-dihydroxyvitamin D3 (1 alpha, 25(OH)(2)D(3)), has received large appreciation due to the broad physiological impact of the hormon...