- Impaired Cognitive Function and Hippocampal Neurogenesis following Cancer Chemotherapy
[作者:Christie, LA; Acharya, MM; Parihar, VK; Nguyen, A; Martirosian, V; Limoli, CL,期刊:Clinical Cancer Research, 页码:1954-1965 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: A substantial proportion of breast cancer survivors report significant, long-lasting impairments in cognitive function, often referred to as "chemobrain." Advances in detection and treatment mean that many more ...
- Cyclin-Dependent Kinase 7/9 Inhibitor SNS-032 Abrogates FIP1-like-1 Platelet-Derived Growth Factor Receptor alpha and Bcr-Abl Oncogene Addiction in Malignant Hematologic Cells
[作者:Wu, YB; Chen, C; Sun, XY; Shi, XP; Jin, B; Ding, K; Yeung, SCJ; Pan, JX,期刊:Clinical Cancer Research, 页码:1966-1978 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: The "gate-keeper" mutations T674I platelet-derived growth factor receptor alpha (PDGFR alpha) in hypereosinophilic syndrome (HES) and T315I Bcr-Abl in chronic myeloid leukemia (CML) are resistant to imatinib and...
- ON 01910.Na Is Selectively Cytotoxic for Chronic Lymphocytic Leukemia Cells through a Dual Mechanism of Action Involving PI3K/AKT Inhibition and Induction of Oxidative Stress
[作者:Chapman, CM; Sun, XM; Roschewski, M; Aue, G; Farooqui, M; Stennett, L; Gibellini, F; Arthur, D; Perez-Galan, P; Wiestner, A,期刊:Clinical Cancer Research, 页码:1979-1991 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Chronic lymphocytic leukemia (CLL), a malignancy of mature B cells, is incurable with chemotherapy. Signals from the microenvironment support leukemic cell survival and proliferation and may confer chemotherapy ...
- Serum Autoantibody Signature of Ductal Carcinoma In Situ Progression to Invasive Breast Cancer
[作者:Mange, A; Lacombe, J; Bascoul-Mollevi, C; Jarlier, M; Lamy, PJ; Rouanet, P; Maudelonde, T; Solassol, J,期刊:Clinical Cancer Research, 页码:1992-2000 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: The identification of markers associated with progression to invasive breast cancer (IBC) is a major factor that can guide physicians in the initial therapeutic decision and the management of ductal carcinoma in...
- Copy Number Gain of 1q25 Predicts Poor Progression-Free Survival for Pediatric Intracranial Ependymomas and Enables Patient Risk Stratification: A Prospective European Clinical Trial Cohort Analysis on Behalf of the Children's Cancer Leukaemia Group (CCLG), Societe Francaise d'Oncologie Pediatrique (SFOP), and International Society for Pediatric Oncology (SIOP)
[作者:Kilday, JP; Mitra, B; Domerg, C; Ward, J; Andreiuolo, F; Osteso-Ibanez, T; Mauguen, A; Varlet, P; Le Deley, MC; Lowe, J; Ellison, DW; Gilbertson, RJ; Coyle, B; Grill, J; Grundy, RG,期刊:Clinical Cancer Research, 页码:2001-2011 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: The high incidence of recurrence and unpredictable clinical outcome for pediatric ependymoma reflect the imprecision of current therapeutic staging and need for novel risk stratification markers. We therefore ev...
- A Three-Gene Expression Signature Model for Risk Stratification of Patients with Neuroblastoma
[作者:Garcia, I; Mayol, G; Rios, J; Domenech, G; Cheung, NKV; Oberthuer, A; Fischer, M; Maris, JM; Brodeur, GM; Hero, B; Rodriguez, E; Sunol, M; Galvan, P; de Torres, C; Mora, J; Lavarino, C,期刊:Clinical Cancer Research, 页码:2012-2023 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Neuroblastoma is an embryonal tumor with contrasting clinical courses. Despite elaborate stratification strategies, precise clinical risk assessment still remains a challenge. The purpose of this study was to de...
- F-18-FDG-PET/CT Imaging as an Early Survival Predictor in Patients with Primary High-Grade Soft Tissue Sarcomas Undergoing Neoadjuvant Therapy
[作者:Herrmann, K; Benz, MR; Czernin, J; Allen-Auerbach, MS; Tap, WD; Dry, SM; Schuster, T; Eckardt, JJ; Phelps, ME; Weber, WA; Eilber, FC,期刊:Clinical Cancer Research, 页码:2024-2031 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Neoadjuvant therapy is associated with considerable toxicity and limited survival benefits in patients with soft tissue sarcoma (STS). We prospectively evaluated whether 2[18F]fluoro-2-deoxy-Dglucose (F-18-FDG)-...
- A Panel of Four miRNAs Accurately Differentiates Malignant from Benign Indeterminate Thyroid Lesions on Fine Needle Aspiration
[作者:Keutgen, XM; Filicori, F; Crowley, MJ; Wang, YC; Scognamiglio, T; Hoda, R; Buitrago, D; Cooper, D; Zeiger, MA; Zarnegar, R; Elemento, O; Fahey, TJ,期刊:Clinical Cancer Research, 页码:2032-2038 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Indeterminate thyroid lesions on fine needle aspiration (FNA) harbor malignancy in about 25% of cases. Hemi- or total thyroidectomy has, therefore, been routinely advocated for definitive diagnosis. In this stud...
- CTLA-4 Blockade with Ipilimumab: Long-term Follow-up of 177 Patients with Metastatic Melanoma
[作者:Prieto, PA; Yang, JC; Sherry, RM; Hughes, MS; Kammula, US; White, DE; Levy, CL; Rosenberg, SA; Phan, GQ,期刊:Clinical Cancer Research, 页码:2039-2047 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Treatment with ipilimumab can cause objective tumor responses in patients with metastatic melanoma. We have treated 177 evaluable patients in three clinical trials and have long-term follow-up to evaluate the du...
- Phase I Study of Rigosertib, an Inhibitor of the Phosphatidylinositol 3-Kinase and Polo-like Kinase 1 Pathways, Combined with Gemcitabine in Patients with Solid Tumors and Pancreatic Cancer
[作者:Ma, WW; Messersmith, WA; Dy, GK; Weekes, CD; Whitworth, A; Ren, C; Maniar, M; Wilhelm, F; Eckhardt, SG; Adjei, AA; Jimeno, A,期刊:Clinical Cancer Research, 页码:2048-2055 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Rigosertib, a dual non-ATP inhibitor of polo-like kinase 1 (Plk1) and phosphoinositide 3-kinase pathways (PI3K), and gemcitabine have synergistic antitumor activity when combined in preclinical studies. This pha...
- Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements
[作者:Hayes, DN; Lucas, AS; Tanvetyanon, T; Krzyzanowska, MK; Chung, CH; Murphy, BA; Gilbert, J; Mehra, R; Moore, DT; Sheikh, A; Hoskins, J; Hayward, MC; Zhao, N; O'Connor, W; Weck, KE; Cohen, RB; Cohen, EEW,期刊:Clinical Cancer Research, 页码:2056-2065 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: A multicenter, open-label, phase II trial was conducted to evaluate the efficacy, safety, and tolerability of selumetinib in iodine-refractory papillary thyroid cancer (IRPTC). Experimental Design: Patients with...
- Phase I/II Trial of Carboplatin and Paclitaxel Chemotherapy in Combination with Intravenous Oncolytic Reovirus in Patients with Advanced Malignancies
[作者:Karapanagiotou, EM; Roulstone, V; Twigger, K; Ball, M; Tanay, M; Nutting, C; Newbold, K; Gore, ME; Larkin, J; Syrigos, KN; Coffey, M; Thompson, B; Mettinger, K; Vile, RG; Pandha, HS; Hall, GD; Melcher, AA; Chester, J; Harrington, KJ,期刊:Clinical Cancer Research, 页码:2080-2089 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Reovirus type 3 Dearing (RT3D) replicates preferentially in Ras-activated cancers. RT3D shows synergistic in vitro cytotoxicity in combination with platins and taxanes. The purpose of this phase I/II study was t...
- Phase II, Open-Label Study of Brivanib as Second-Line Therapy in Patients with Advanced Hepatocellular Carcinoma
[作者:Finn, RS; Kang, YK; Mulcahy, M; Polite, BN; Lim, HY; Walters, I; Baudelet, C; Manekas, D; Park, JW,期刊:Clinical Cancer Research, 页码:2090-2098 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Brivanib, a selective dual inhibitor of fibroblast growth factor and VEGF signaling, has recently been shown to have activity as first-line treatment for patients with advanced hepatocellular carcinoma (HCC). Th...
- Sorafenib Is an Inhibitor of UGT1A1 but Is Metabolized by UGT1A9: Implications of Genetic Variants on Pharmacokinetics and Hyperbilirubinemia
[作者:Peer, CJ; Sissung, TM; Kim, A; Jain, L; Woo, S; Gardner, ER; Kirkland, CT; Troutman, SM; English, BC; Richardson, ED; Federspiel, J; Venzon, D; Dahut, W; Kohn, E; Kummar, S; Yarchoan, R; Giaccone, G; Widemann, B; Figg, WD,期刊:Clinical Cancer Research, 页码:2099-2107 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Several case reports suggest sorafenib exposure and sorafenib-induced hyperbilirubinemia may be related to a (TA)(5/6/7) repeat polymorphism in UGT1A1*28 (UGT, uridine glucuronosyl transferase). We hypothesized ...
- Tumor Hypoxia Predicts Biochemical Failure following Radiotherapy for Clinically Localized Prostate Cancer
[作者:Milosevic, M; Warde, P; Menard, C; Chung, P; Toi, A; Ishkanian, A; McLean, M; Pintilie, M; Sykes, J; Gospodarowicz, M; Catton, C; Hill, RP; Bristow, R,期刊:Clinical Cancer Research, 页码:2108-2114 , 文章类型: Article,,卷期:2012年18-7]
- Purpose: Tumor hypoxia is an important determinant of outcome in many human malignancies and is associated with treatment resistance and metastases. The aim of this study was to determine the effect of hypoxia in patient...
|