- Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2
[作者:Niles, BJ; Mogri, H; Hill, A; Vlahakis, A; Powers, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1536-1541 , 文章类型: Article,,卷期:2012年109-5]
- The yeast AGC kinase orthologs Ypk1 and Ypk2 control several important cellular processes, including actin polarization, endocytosis, and sphingolipid metabolism. Activation of Ypk1/2 requires phosphorylation by kinases ...
- Nematode sperm maturation triggered by protease involves sperm-secreted serine protease inhibitor (Serpin)
[作者:Zhao, YM; Sun, W; Zhang, P; Chi, H; Zhang, MJ; Song, CQ; Ma, X; Shang, YL; Wang, B; Hu, YQ; Hao, ZQ; Huhmer, AF; Meng, FX; L'Hernault, SW; He, SM; Dong, MQ; Miao, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1542-1547 , 文章类型: Article,,卷期:2012年109-5]
- Spermiogenesis is a series of poorly understood morphological, physiological and biochemical processes that occur during the transition of immotile spermatids into motile, fertilization-competent spermatozoa. Here, we id...
- Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis
[作者:Grunewald, W; De Smet, I; Lewis, DR; Lofke, C; Jansen, L; Goeminne, G; Bossche, RV; Karimi, M; De Rybel, B; Vanholme, B; Teichmann, T; Boerjan, W; Van Montagu, MCE; Gheysen, G; Muday, GK; Friml, J; Beeckman, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1554-1559 , 文章类型: Article,,卷期:2012年109-5]
- Gradients of the plant hormone auxin, which depend on its active intercellular transport, are crucial for the maintenance of root meristematic activity. This directional transport is largely orchestrated by a complex int...
- Characterization of MADS-domain transcription factor complexes in Arabidopsis flower development
[作者:Smaczniak, C; Immink, RGH; Muino, JM; Blanvillain, R; Busscher, M; Busscher-Lange, J; Dinh, QD; Liu, SJ; Westphal, AH; Boeren, S; Parcy, F; Xu, L; Carles, CC; Angenent, GC; Kaufmann, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1560-1565 , 文章类型: Article,,卷期:2012年109-5]
- Floral organs are specified by the combinatorial action of MADS-domain transcription factors, yet the mechanisms by which MADS-domain proteins activate or repress the expression of their target genes and the nature of th...
- BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord
[作者:Ding, Q; Joshi, PS; Xie, ZH; Xiang, MQ; Gan, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1566-1571 , 文章类型: Article,,卷期:2012年109-5]
- In the dorsal spinal cord, distinct interneuron classes relay specific somatosensory information, such as touch, heat, and pain, from the periphery to higher brain centers via ipsilateral and contralateral axonal pathway...
- Transcriptional interpretation of the EGF receptor signaling gradient
[作者:Fuchs, A; Cheung, LS; Charbonnier, E; Shvartsman, SY; Pyrowolakis, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1572-1577 , 文章类型: Article,,卷期:2012年109-5]
- Epidermal growth factor receptor (EGFR) controls a wide range of developmental events, from body axes specification in insects to cardiac development in humans. During Drosophila oogenesis, a gradient of EGFR activation ...
- Homeobox gene distal-less is required for neuronal differentiation and neurite outgrowth in the Drosophila olfactory system
[作者:Plavicki, J; Mader, S; Pueschel, E; Peebles, P; Boekhoff-Falk, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1578-1583 , 文章类型: Article,,卷期:2012年109-5]
- Vertebrate Dlx genes have been implicated in the differentiation of multiple neuronal subtypes, including cortical GABAergic interneurons, and mutations in Dlx genes have been linked to clinical conditions such as epilep...
- Carnivorous dinocephalian from the Middle Permian of Brazil and tetrapod dispersal in Pangaea
[作者:Cisneros, JC; Abdala, F; Atayman-Guven, S; Rubidge, BS; Sengor, AMC; Schultz, CL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1584-1588 , 文章类型: Article,,卷期:2012年109-5]
- The medial Permian (similar to 270-260 Ma: Guadalupian) was a time of important tetrapod faunal changes, in particular reflecting a turnover from pelycosaurian- to therapsid-grade synapsids. Until now, most knowledge on ...
- Experimental evolution of multicellularity
[作者:Ratcliff, WC; Denison, RF; Borrello, M; Travisano, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1595-1600 , 文章类型: Article,,卷期:2012年109-5]
- Multicellularity was one of the most significant innovations in the history of life, but its initial evolution remains poorly understood. Using experimental evolution, we show that key steps in this transition could have...
|