- Terminal Interface Conformations Modulate Dimer Stability Prior to Amino Terminal Autoprocessing of HIV-1 Protease
[作者:Agniswamy, J; Sayer, JM; Weber, IT; Louis, JM,期刊:Biochemistry, 页码:1041-1050 , 文章类型: Article,,卷期:2012年51-5]
- The HIV-1 protease (PR) mediates its own release (autoprocessing) from the polyprotein precursor, Gag-Pol, flanked by the transframe region (TFR) and reverse transcriptase at its N- and C-termini, respectively. Autoproce...
- A DNA-Based Nanomechanical Device Used To Characterize the Distortion of DNA by Apo-SoxR Protein
[作者:Liu, CH; Kim, E; Demple, B; Seeman, NC,期刊:Biochemistry, 页码:937-943 , 文章类型: Article,,卷期:2012年51-5]
- DNA-based nanomechanical devices can be used to characterize the action of DNA-distorting proteins. Here, we have constructed a device wherein two DNA triple-crossover (TX) molecules are connected by a shaft, similar to ...
- Human CCAAT/Enhancer-Binding Protein beta Interacts with Chromatin Remodeling Complexes of the Imitation Switch Subfamily
[作者:Steinberg, XP; Hepp, MI; Garcia, YF; Suganuma, T; Swanson, SK; Washburn, M; Workman, JL; Gutierrez, JL,期刊:Biochemistry, 页码:952-962 , 文章类型: Article,,卷期:2012年51-5]
- Transcription factor C/EBP beta is involved in several cellular processes, such as proliferation, differentiation, and energy metabolism. This factor exerts its activity through recruitment of different proteins or prote...
- The Diheme Cytochrome c Peroxidase from Shewanella oneidensis Requires Reductive Activation
[作者:Pulcu, GS; Frato, KE; Gupta, R; Hsu, HR; Levine, GA; Hendrich, MP; Elliott, SJ,期刊:Biochemistry, 页码:974-985 , 文章类型: Article,,卷期:2012年51-5]
- We report the characterization of the diheme cytochrome c peroxidase (CcP) from Shewanella oneidensis (So) using UV-visible absorbance, electron paramagnetic resonance spectroscopy, and Michaelis-Menten kinetics. While s...
- Directed Evolution of the Suicide Protein O-6-Alkylguanine-DNA Alkyltransferase for Increased Reactivity Results in an Alkylated Protein with Exceptional Stability
[作者:Mollwitz, B; Brunk, E; Schmitt, S; Pojer, F; Bannwarth, M; Schiltz, M; Rothlisberger, U; Johnsson, K,期刊:Biochemistry, 页码:986-994 , 文章类型: Article,,卷期:2012年51-5]
- Here we present a biophysical, structural, and computational analysis of the directed evolution of the human DNA repair protein O-6-alkylguanine-DNA alkyltransferase (hAGT) into SNAP-tag, a self-labeling protein tag. Evo...
- Role of Individual Histidines in the pH-Dependent Global Stability of Human Chloride Intracellular Channel 1
[作者:Achilonu, I; Fanucchi, S; Cross, M; Fernandes, M; Dirr, HW,期刊:Biochemistry, 页码:995-1004 , 文章类型: Article,,卷期:2012年51-5]
- Chloride intracellular channel proteins exist in both a soluble cytosolic form and a membrane-bound form. The mechanism of conversion between the two forms is not properly understood, although one of the contributing fac...
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