- Rifaximin Improves Driving Simulator Performance in a Randomized Trial of Patients With Minimal Hepatic Encephalopathy
[作者:Bajaj, JS; Heuman, DM; Wade, JB; Gibson, DP; Saeian, K; Wegelin, JA; Hafeezullah, M; Bell, DE; Sterling, RK; Stravitz, RT; Fuchs, M; Luketic, V; Sanyal, AJ,期刊:Gastroenterology, 页码:478-U179 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: Patients with cirrhosis and minimal hepatic encephalopathy (MHE) have driving difficulties but the effects of therapy on driving performance is unclear. We evaluated whether performance on a driving si...
- Prognostic Importance of the Cause of Renal Failure in Patients With Cirrhosis
[作者:Martin-Llahi, M; Guevara, M; Torre, A; Fagundes, C; Restuccia, T; Gilabert, R; Sola, E; Pereira, G; Marinelli, M; Pavesi, M; Fernandez, J; Rodes, J; Arroyo, V; Gines, P,期刊:Gastroenterology, 页码:488-U192 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: The prognostic value of the different causes of renal failure in cirrhosis is not well established. This study investigated the predictive value of the cause of renal failure in cirrhosis. METHODS: Fiv...
- Radioembolization Results in Longer Time-to-Progression and Reduced Toxicity Compared With Chemoembolization in Patients With Hepatocellular Carcinoma
[作者:Salem, R; Lewandowski, RJ; Kulik, L; Wang, E; Riaz, A; Ryu, RK; Sato, KT; Gupta, R; Nikolaidis, P; Miller, FH; Yaghmai, V; Ibrahim, SM; Senthilnathan, S; Baker, T; Gates, VL; Atassi, B; Newman, S; Memon, K; Chen, R; Vogelzang, RL; Nemcek, AA; Resnick, SA; Chrisman, HB; Carr, J; Omary, RA; Abecassis, M; Benson, AB; Mulcahy, MF,期刊:Gastroenterology, 页码:497-U205 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: Chemoembolization is one of several standards of care treatment for hepatocellular carcinoma (HCC). Radioembolization with Yttrium-90 microspheres is a novel, transarterial approach to radiation therap...
- Cdx2 Levels Modulate Intestinal Epithelium Maturity and Paneth Cell Development
[作者:Crissey, MAS; Guo, RJ; Funakoshi, S; Kong, JP; Liu, J; Lynch, JP,期刊:Gastroenterology, 页码:517-U234 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: Caudal-related homeobox protein 2 (Cdx2) is an intestine-specific transcription factor that is important for intestinal development and intestine-specific gene expression. Cdx2 regulates intestinal cel...
- Level of Activation of the Unfolded Protein Response Correlates With Paneth Cell Apoptosis in Human Small Intestine Exposed to Ischemia/Reperfusion
[作者:Grootjans, J; Hodin, CM; de Haan, JJ; Derikx, JPM; Rouschop, KMA; Verheyen, FK; van Dam, RM; Dejong, CHC; Buurman, WA; Lenaerts, K,期刊:Gastroenterology, 页码:529-U248 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: In the intestine, Paneth cells participate in the innate immune response. Their highly secretory function makes them susceptible to environmental conditions that cause endoplasmic reticulum (ER) stress...
- Kruppel-Like Factor 5 Protects Against Dextran Sulfate Sodium-Induced Colonic Injury in Mice by Promoting Epithelial Repair
[作者:McConnell, BB; Kim, SS; Bialkowska, AB; Yu, K; Sitaraman, SV; Yang, VW,期刊:Gastroenterology, 页码:540-U260 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: Kruppel-like factor 5 (KLF5) is a transcription factor that promotes proliferation, is highly expressed in dividing crypt cells of the gastrointestinal epithelium, and is induced by various stress stim...
- Notch-1 Signaling Regulates Intestinal Epithelial Barrier Function, Through Interaction With CD4(+) T Cells, in Mice and Humans
[作者:Dahan, S; Rabinowitz, KM; Martin, AP; Berin, MC; Unkeless, JC; Mayer, L,期刊:Gastroenterology, 页码:550-559 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: Interactions between lymphocytes and intestinal epithelial cells occur in the subepithelial space of the gastrointestinal tract. Normal human lamina propria lymphocytes (LPLs) induce differentiation of...
- D-Glucose Acts via Sodium/Glucose Cotransporter 1 to Increase NHE3 in Mouse Jejunal Brush Border by a Na plus/H plus Exchange Regulatory Factor 2-Dependent Process
[作者:Lin, R; Murtazina, R; Cha, BY; Chakraborty, M; Sarker, R; Chen, TE; Lin, ZH; Hogema, BM; de Jonge, HR; Seidler, U; Turner, JR; Li, XH; Kovbasnjuk, O; Donowitz, M,期刊:Gastroenterology, 页码:560-571 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: Oral rehydration solutions reduce diarrhea-associated mortality. Stimulated sodium absorption by these solutions is mediated by the Na+/H+ hydrogen exchanger NHE3 and is increased by Na+-glucose co-tra...
- Variants in RET Associated With Hirschsprung's Disease Affect Binding of Transcription Factors and Gene Expression
[作者:Sribudiani, Y; Metzger, M; Osinga, J; Rey, A; Burns, AJ; Thapar, N; Hofstra, RMW,期刊:Gastroenterology, 页码:572-U295 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: Two noncoding variations in RET-the T allele of the single nucleotide polymorphism (SNP) rs2435357 (Enh1:C>T) and the A allele of the SNP rs2506004 (Enh2:C>A)-are associated with Hirschsprung's disease...
- Annexin A2 Mediates Up-regulation of NF-kappa B, beta-catenin, and Stem Cell in Response to Progastrin in Mice and HEK-293 Cells
[作者:Sarkar, S; Swiercz, R; Kantara, C; Hajjar, KA; Singh, P,期刊:Gastroenterology, 页码:583-U312 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: Prograstrin induces proliferation in colon crypts by activating p65nuclear factor-kappa B (NF-kappa B) (p65) and beta-catenin. We investigated whether Annexin A2 (AnxA2), a progastrin receptor, activat...
- Prostaglandin E-2 2 Signaling and Bacterial Infection Recruit Tumor-Promoting Macrophages to Mouse Gastric Tumors
[作者:Oshima, H; Hioki, K; Popivanova, BK; Oguma, K; Van Rooijen, N; Ishikawa, TO; Oshima, M,期刊:Gastroenterology, 页码:596-U331 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: Helicobacter pylori infection induces an inflammatory response, which can contribute to gastric tumorigenesis. Induction of cyclooxygenase-2 (COX-2) results in production of prostaglandin E-2 (PGE(2)),...
- beta-Nicotinamide Adenine Dinucleotide Is an Enteric Inhibitory Neurotransmitter in Human and Nonhuman Primate Colons
[作者:Hwang, SJ; Durnin, L; Dwyer, L; Rhee, PL; Ward, SM; Koh, SD; Sanders, KM; Mutafova-Yambolieva, VN,期刊:Gastroenterology, 页码:608-U347 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: An important component of enteric inhibitory neurotransmission is mediated by a purine neurotransmitter, such as adenosine 5'-triphosphate (ATP), binding to P2Y1 receptors and activating small conducta...
- Morphine Induces mu Opioid Receptor Endocytosis in Guinea Pig Enteric Neurons Following Prolonged Receptor Activation
[作者:Patierno, S; Anselmi, L; Jaramillo, I; Scott, D; Garcia, R; Sternini, C,期刊:Gastroenterology, 页码:618-626 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: The mu opioid receptor (mu OR) undergoes rapid endocytosis after acute stimulation with opioids and most opiates, but not with morphine. We investigated whether prolonged activation of mu OR affects mo...
- Corticosterone Mediates Reciprocal Changes in CB 1 and TRPV1 Receptors in Primary Sensory Neurons in the Chronically Stressed Rat
[作者:Hong, SS; Zheng, G; Wu, XY; Snider, NT; Owyang, C; Wiley, JW,期刊:Gastroenterology, 页码:627-U371 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: Chronic stress is associated with visceral hyperalgesia in functional gastrointestinal disorders. We investigated whether corticosterone plays a role in chronic psychological stress-induced visceral hy...
- Brain Region-Selective Mechanisms Contribute to the Progression of Cerebral Alterations in Acute Liver Failure in Rats
[作者:Cauli, O; Lopez-Larrubia, P; Rodrigo, R; Agusti, A; Boix, J; Nieto-Charques, L; Cerdan, S; Felipo, V,期刊:Gastroenterology, 页码:638-645 , 文章类型: Article,,卷期:2011年140-2]
- BACKGROUND & AIMS: Patients with acute liver failure (ALF) often die of intracranial pressure (IP) and cerebral herniation. Main contributors to increased IP are ammonia, glutamine, edema, and blood flow. The sequence of...
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