- Terminal Differentiation, Advanced Organotypic Maturation, and Modeling of Hypertrophic Growth in Engineered Heart Tissue
[作者:Tiburcy, M; Didie, M; Boy, O; Christalla, P; Doker, S; Naito, H; Karikkineth, BC; El-Armouche, A; Grimm, M; Nose, M; Eschenhagen, T; Zieseniss, A; Katschinksi, DM; Hamdani, N; Linke, WA; Yin, XK; Mayr, M; Zimmermann, WH,期刊:Circulation Research, 页码:1105-NIL_46 , 文章类型: Article,,卷期:2011年109-10]
- Rationale: Cardiac tissue engineering should provide "realistic" in vitro heart muscle models and surrogate tissue for myocardial repair. For either application, engineered myocardium should display features of native my...
- MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation
[作者:Boon, RA; Seeger, T; Heydt, S; Fischer, A; Hergenreider, E; Horrevoets, AJG; Vinciguerra, M; Rosenthal, N; Sciacca, S; Pilato, M; van Heijningen, P; Essers, J; Brandes, RP; Zeiher, AM; Dimmeler, S,期刊:Circulation Research, 页码:1115-NIL_66 , 文章类型: Article,,卷期:2011年109-10]
- Rationale: Aging represents a major risk factor for coronary artery disease and aortic aneurysm formation. MicroRNAs (miRs) have emerged as key regulators of biological processes, but their role in age-associated vascula...
- Abolishing Myofibroblast Arrhythmogeneicity by Pharmacological Ablation of alpha-Smooth Muscle Actin Containing Stress Fibers
[作者:Rosker, C; Salvarani, N; Schmutz, S; Grand, T; Rohr, S,期刊:Circulation Research, 页码:1120-1131 , 文章类型: Article,,卷期:2011年109-10]
- Rationale: Myofibroblasts typically appear in the myocardium after insults to the heart like mechanical overload and infarction. Apart from contributing to fibrotic remodeling, myofibroblasts induce arrhythmogenic slow c...
- Coupling of Fc gamma Receptor I to Fc gamma Receptor IIB by Src Kinase Mediates C-Reactive Protein Impairment of Endothelial Function
[作者:Sundgren, NC; Zhu, WF; Yuhanna, IS; Chambliss, KL; Ahmed, M; Tanigaki, K; Umetani, M; Mineo, C; Shaul, PW,期刊:Circulation Research, 页码:1132-NIL_90 , 文章类型: Article,,卷期:2011年109-10]
- Rationale: Elevations in C-reactive protein (CRP) are associated with increased cardiovascular disease risk and endothelial dysfunction. CRP antagonizes endothelial nitric oxide synthase (eNOS) through processes mediated...
- Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism
[作者:Parathath, S; Mick, SL; Feig, JE; Joaquin, V; Grauer, L; Habiel, DM; Gassmann, M; Gardner, LB; Fisher, EA,期刊:Circulation Research, 页码:1141-NIL_114 , 文章类型: Article,,卷期:2011年109-10]
- Rationale: Human atherosclerotic plaques contain large numbers of cells deprived of O(2). In murine atherosclerosis, because the plaques are small, it is controversial whether hypoxia can occur.Objective: To examine if m...
- Intrinsic Aerobic Capacity Sets a Divide for Aging and Longevity
[作者:Koch, LG; Kemi, OJ; Qi, N; Leng, SX; Bijma, P; Gilligan, LJ; Wilkinson, JE; Wisloff, H; Hoydal, MA; Rolim, N; Abadir, PM; van Grevenhof, EM; Smith, GL; Burant, CF; Ellingsen, O; Britton, SL; Wisloff, U,期刊:Circulation Research, 页码:1162-NIL_151 , 文章类型: Article,,卷期:2011年109-10]
- Rationale: Low aerobic exercise capacity is a powerful predictor of premature morbidity and mortality for healthy adults as well as those with cardiovascular disease. For aged populations, poor performance on treadmill o...
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