- Role of the Cholinergic Antiinflammatory Pathway in Murine Autoimmune Myocarditis
[作者:Leib, C; Goser, S; Luthje, D; Ottl, R; Tretter, T; Lasitschka, F; Zittrich, S; Pfitzer, G; Katus, HA; Kaya, Z,期刊:Circulation Research, 页码:130-U31 , 文章类型: Article,,卷期:2011年109-2]
- Rationale: This study was performed to gain insights into novel therapeutic approaches for the treatment of autoimmune myocarditis. Objective: Chemical stimulation of the efferent arm of the vagus nerve through activatio...
- A Critical Function for Ser-282 in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function
[作者:Sadayappan, S; Gulick, J; Osinska, H; Barefield, D; Cuello, F; Avkiran, M; Lasko, VM; Lorenz, JN; Maillet, M; Martin, JL; Brown, JH; Bers, DM; Molkentin, JD; James, J; Robbins, J,期刊:Circulation Research, 页码:141-U46 , 文章类型: Article,,卷期:2011年109-2]
- Rationale: Cardiac myosin-binding protein-C (cMyBP-C) phosphorylation at Ser-273, Ser-282, and Ser-302 regulates myocardial contractility. In vitro and in vivo experiments suggest the nonequivalence of these sites and th...
- Endogenous Muscle Atrophy F-Box Mediates Pressure Overload-Induced Cardiac Hypertrophy Through Regulation of Nuclear Factor-kappa B
[作者:Usui, S; Maejima, Y; Pain, J; Hong, C; Cho, J; Park, JY; Zablocki, D; Tian, B; Glass, DJ; Sadoshima, J,期刊:Circulation Research, 页码:161-U94 , 文章类型: Article,,卷期:2011年109-2]
- Rationale: Overexpression of muscle atrophy F-box (MAFbx/atrogin-1), an E3 ubiquitin ligase, induces proteasomal degradation in cardiomyocytes. The role of endogenous MAFbx in regulating cardiac hypertrophy and failure r...
- Laminin-Binding Integrins Induce Dll4 Expression and Notch Signaling in Endothelial Cells
[作者:Estrach, S; Cailleteau, L; Franco, CA; Gerhardt, H; Stefani, C; Lemichez, E; Gagnoux-Palacios, L; Meneguzzi, G; Mettouchi, A,期刊:Circulation Research, 页码:172-U116 , 文章类型: Article,,卷期:2011年109-2]
- Rationale: Integrins play a crucial role in controlling endothelial cell proliferation and migration during angiogenesis. The Delta-like 4 (Dll4)/Notch pathway establishes an adequate ratio between stalk and tip cell pop...
- Nfatc1 Coordinates Valve Endocardial Cell Lineage Development Required for Heart Valve Formation
[作者:Wu, BR; Wang, YD; Lui, W; Langworthy, M; Tompkins, KL; Hatzopoulos, AK; Baldwin, HS; Zhou, B,期刊:Circulation Research, 页码:183-U134 , 文章类型: Article,,卷期:2011年109-2]
- Rationale: Formation of heart valves requires early endocardial to mesenchymal transformation (EMT) to generate valve mesenchyme and subsequent endocardial cell proliferation to elongate valve leaflets. Nfatc1 (nuclear f...
- Interactions Between Ankyrin-G, Plakophilin-2, and Connexin43 at the Cardiac Intercalated Disc
[作者:Sato, PY; Coombs, W; Lin, XM; Nekrasova, O; Green, KJ; Isom, LL; Taffet, SM; Delmar, M,期刊:Circulation Research, 页码:193-U160 , 文章类型: Article,,卷期:2011年109-2]
- Rationale: The early description of the intercalated disc defined 3 structures, all of them involved in cell-cell communication: desmosomes, gap junctions, and adherens junctions. Current evidence demonstrates that molec...
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