- Aortic Aneurysm Generation in Mice With Targeted Deletion of Integrin-Linked Kinase in Vascular Smooth Muscle Cells
[作者：Shen, DX; Li, J; Lepore, JJ; Anderson, TJT; Sinha, S; Lin, AY; Cheng, L; Cohen, ED; Roberts, JD; Dedhar, S; Parmacek, MS; Gerszten, RE,期刊：Circulation Research, 页码：616-U78 , 文章类型： Article，,卷期：2011年109-6]
- Rationale: Integrin-linked kinase (ILK) is located at focal adhesions and links the extracellular matrix (ECM) to the actin cytoskeleton via beta 1- and beta 3-integrins. ILK plays a role in the activation of kinases inc...
- beta-Myosin Heavy Chain Is Induced by Pressure Overload in a Minor Subpopulation of Smaller Mouse Cardiac Myocytes
[作者：Lopez, JE; Myagmar, BE; Swigart, PM; Montgomery, MD; Haynam, S; Bigos, M; Rodrigo, MC; Simpson, PC,期刊：Circulation Research, 页码：629-U98 , 文章类型： Article，,卷期：2011年109-6]
- Rationale: Induction of the fetal hypertrophic marker gene beta-myosin heavy chain (beta-MyHC) is a signature feature of pressure overload hypertrophy in rodents. beta-MyHC is assumed present in all or most enlarged myoc...
- Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction
[作者：Zhou, S; Chen, HZ; Wan, YZ; Zhang, QJ; Wei, YS; Huang, SA; Liu, JJ; Lu, YB; Zhang, ZQ; Yang, RF; Zhang, R; Cai, H; Liu, DP; Liang, CC,期刊：Circulation Research, 页码：639-U125 , 文章类型： Article，,卷期：2011年109-6]
- Rationale: Inactivation of the p66Shc adaptor protein confers resistance to oxidative stress and protects mice from aging-associated vascular diseases. However, there is limited information about the negative regulating ...
- Haploinsufficiency of Target of Rapamycin Attenuates Cardiomyopathies in Adult Zebrafish
[作者：Ding, YH; Sun, XJ; Huang, W; Hoage, T; Redfield, M; Kushwaha, S; Sivasubbu, S; Lin, XY; Ekker, S; Xu, XL,期刊：Circulation Research, 页码：658-U175 , 文章类型： Article，,卷期：2011年109-6]
- Rationale: Although a cardioprotective function of target of rapamycin (TOR) signaling inhibition has been suggested by pharmacological studies using rapamycin, genetic evidences are still lacking. We explored adult zebr...
- miR-15 Family Regulates Postnatal Mitotic Arrest of Cardiomyocytes
[作者：Porrello, ER; Johnson, BA; Aurora, AB; Simpson, E; Nam, YJ; Matkovich, SJ; Dorn, GW; van Rooij, E; Olson, EN,期刊：Circulation Research, 页码：670-U208 , 文章类型： Article，,卷期：2011年109-6]
- Rationale: Mammalian cardiomyocytes withdraw from the cell cycle during early postnatal development, which significantly limits the capacity of the adult mammalian heart to regenerate after injury. The regulatory mechani...
- Exome Sequencing Identifies SMAD3 Mutations as a Cause of Familial Thoracic Aortic Aneurysm and Dissection With Intracranial and Other Arterial Aneurysms
[作者：Regalado, ES; Guo, DC; Villamizar, C; Avidan, N; Gilchrist, D; McGillivray, B; Clarke, L; Bernier, F; Santos-Cortez, RL; Leal, SM; Bertoli-Avella, AM; Shendure, J; Rieder, MJ; Nickerson, DA; Milewicz, DM,期刊：Circulation Research, 页码：680-U220 , 文章类型： Article，,卷期：2011年109-6]
- Rationale: Thoracic aortic aneurysms leading to acute aortic dissections (TAAD) can be inherited in families in an autosomal dominant manner. As part of the spectrum of clinical heterogeneity of familial TAAD, we recentl...
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