- Calcium Regulates Key Components of Vascular Smooth Muscle Cell-Derived Matrix Vesicles to Enhance Mineralization
[作者:Kapustin, AN; Davies, JD; Reynolds, JL; McNair, R; Jones, GT; Sidibe, A; Schurgers, LJ; Skepper, JN; Proudfoot, D; Mayr, M; Shanahan, CM,期刊:Circulation Research, 页码:E1-U41 , 文章类型: Article,,卷期:2011年109-1]
- Rationale: Matrix vesicles (MVs) are specialized structures that initiate mineral nucleation during physiological skeletogenesis. Similar vesicular structures are deposited at sites of pathological vascular calcification...
- Neonatal Mouse-Derived Engineered Cardiac Tissue A Novel Model System for Studying Genetic Heart Disease
[作者:de Lange, WJ; Hegge, LF; Grimes, AC; Tong, CW; Brost, TM; Moss, RL; Ralphe, JC,期刊:Circulation Research, 页码:8-U81 , 文章类型: Article,,卷期:2011年109-1]
- Rationale: Cardiomyocytes cultured in a mechanically active 3-dimensional configuration can be used for studies that correlate contractile performance to cellular physiology. Current engineered cardiac tissue (ECT) model...
- Methodological Development of a Clonogenic Assay to Determine Endothelial Progenitor Cell Potential
[作者:Masuda, H; Alev, C; Akimaru, H; Ito, R; Shizuno, T; Kobori, M; Horii, M; Ishihara, T; Isobe, K; Isozaki, M; Itoh, J; Itoh, Y; Okada, Y; McIntyre, BAS; Kato, S; Asahara, T,期刊:Circulation Research, 页码:20-U141 , 文章类型: Article,,卷期:2011年109-1]
- The precise and conceptual insight of circulating endothelial progenitor cell (EPC) kinetics is hampered by the absence of an assay system capable of evaluating the EPC differentiation cascade. An assay system for EPC co...
- Informatic and Functional Approaches to Identifying a Regulatory Region for the Cardiac Sodium Channel
[作者:Atack, TC; Stroud, DM; Watanabe, H; Yang, T; Hall, L; Hipkens, SB; Lowe, JS; Leake, B; Magnuson, MA; Yang, P; Roden, DM,期刊:Circulation Research, 页码:38-U165 , 文章类型: Article,,卷期:2011年109-1]
- Rationale: Although multiple lines of evidence suggest that variable expression of the cardiac sodium channel gene SCN5A plays a role in susceptibility to arrhythmia, little is known about its transcriptional regulation....
- Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture
[作者:Tulloch, NL; Muskheli, V; Razumova, MV; Korte, FS; Regnier, M; Hauch, KD; Pabon, L; Reinecke, H; Murry, CE,期刊:Circulation Research, 页码:47-U195 , 文章类型: Article,,卷期:2011年109-1]
- Rationale: The developing heart requires both mechanical load and vascularization to reach its proper size, yet the regulation of human heart growth by these processes is poorly understood. Objective: We seek to elucidat...
- Reprogramming of Skeletal Myoblasts for Induction of Pluripotency for Tumor-Free Cardiomyogenesis in the Infarcted Heart
[作者:Ahmed, RPH; Haider, HK; Buccini, S; Li, LH; Jiang, SJ; Ashraf, M,期刊:Circulation Research, 页码:60-U220 , 文章类型: Article,,卷期:2011年109-1]
- Rationale: Skeletal myoblasts (SMs) with inherent myogenic properties are better candidates for reprogramming to pluripotency. Objective: To reprogram SMs to pluripotency and show that reprogrammed SMs (SiPS) express emb...
- Pannexin1 Regulates alpha 1-Adrenergic Receptor-Mediated Vasoconstriction
[作者:Billaud, M; Lohman, AW; Straub, AC; Looft-Wilson, R; Johnstone, SR; Araj, CA; Best, AK; Chekeni, FB; Ravichandran, KS; Penuela, S; Laird, DW; Isakson, BE,期刊:Circulation Research, 页码:80-U284 , 文章类型: Article,,卷期:2011年109-1]
- Rationale: The coordination of vascular smooth muscle cell constriction plays an important role in vascular function, such as regulation of blood pressure; however, the mechanism responsible for vascular smooth muscle ce...
- Phenotypic Manifestations of Mutations in Genes Encoding Subunits of Cardiac Potassium Channels
[作者:Shimizu, W; Horie, M,期刊:Circulation Research, 页码:97-109 , 文章类型: Review,,卷期:2011年109-1]
- Since 1995, when a potassium channel gene, hERG (human either-a-go-go-related gene), now referred to as KCNH2, encoding the rapid component of cardiac delayed rectifier potassium channels was identified as being responsi...
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