- Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies
[作者:DOCKENDORFF CHRIS; NAGIEC MAREK M; WEIWER MICHEL; BUHRLAGE SARA; TING AMAL; NAG PARTHA P; GERMAIN ANDREW; KIM HANJE; YOUNGSAYE WILLMEN; SCHERER CHRISTINA; BENNION MELISSA; XUE LINLONG; STANTON BENJAMIN Z; LEWIS TIMOTHY A; MACPHERSON LAWRENCE; PALMER MICHELLE; FOLEY MICHAEL A; PEREZ JOSE R; SCHREIBER STUART L,期刊:ACS Medicinal Chemistry Letters, 页码:808-813 , 文章类型: Article,,卷期:2012年3-10]
- Macrocyclic Hedgehog (Hh) pathway inhibitors have been discovered with improved potency and maximal inhibition relative to the previously reported macrocycle robotnikinin. Analogues were prepared using a modular and effi...
- Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate
[作者:KEITH JOHN M; APODACA RICH; TICHENOR MARK; XIAO WEI; JONES WILLIAM; PIERCE JOAN; SEIERSTAD MARK; PALMER JAMES; WEBB MICHAEL; KARBARZ MARK; SCOTT BRIAN; WILSON SANDY; LUO LIN; WENNERHOLM MICHELLE; CHANG LEON; BROWN SEAN; RIZZOLIO MICHELE; RYNBERG RAYMOND; CHAPLAN SANDRA; BREITENBUCHER J GUY,期刊:ACS Medicinal Chemistry Letters, 页码:823-827 , 文章类型: Article,,卷期:2012年3-10]
- A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elev...
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