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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells [作者：Ahn, GO; Brown, JM,期刊：Cancer Cell, 页码：193-205 , 文章类型： Article，,卷期：2008年13-3] Tumor vasculature is derived from sprouting of local vessels (angiogenesis) and bone marrow (BM)-derived circulating cells (vasculogenesis). By using a model system of transplanting tumors into an irradiated normal tissu... HIF1 alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion [作者：Du, R; Lu, KV; Petritsch, C; Liu, P; Ganss, R; Passegue, E; Song, H; VandenBerg, S; Johnson, RS; Werb, Z; Bergers, G,期刊：Cancer Cell, 页码：206-220 , 文章类型： Article，,卷期：2008年13-3] Development of hypoxic regions is an indicator of poor prognosis in many tumors. Here, we demonstrate that HIR1 alpha, the direct effector of hypoxia, partly through increases in SDF1 alpha, induces recruitment of bone m... The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151 [作者：Zijlstra, A; Lewis, J; DeGryse, B; Stuhimann, H; Quigley, JP,期刊：Cancer Cell, 页码：221-234 , 文章类型： Article，,卷期：2008年13-3] In vivo tumor cell migration through integrin-dependent pathways is key to the metastatic behavior of malignant cells. Using quantitative in vivo assays and intravital imaging, we assessed the impact of cell migration, r... Yes and PI3K bind CD95 to signal invasion of glioblastoma [作者：Kleber, S; Sancho-Martinez, I; Wiestler, B; Beisel, A; Gieffers, C; Hill, O; Thiemann, M; Mueller, W; Sykora, J; Kuhn, A; Schreglmann, N; Letellier, E; Zuliani, C; Klussmann, S; Teodorczyk, M; Grone, HJ; Ganten, TM; Sultmann, H; Tuttenberg, J; von Deimling, A; Regnier-Vigouroux, A; Herold-Mende, C; Martin-Villalba, A,期刊：Cancer Cell, 页码：235-248 , 文章类型： Article，,卷期：2008年13-3] Invasion of surrounding brain tissue by isolated tumor cells represents one of the main obstacles to a curative therapy of glioblastoma multiforme. Here we unravel a mechanism regulating glioma infiltration. Tumor intera... Transient inhibition of the hedgehog pathway in young mice causes permanent defects in bone structure [作者：Kimura, H; Ng, JMY; Curran, T,期刊：Cancer Cell, 页码：249-260 , 文章类型： Article，,卷期：2008年13-3] The Hedgehog (Hh) pathway plays critical roles in normal development and in tumorigenesis. We generated Gli-luciferase transgenic mice to evaluate the Smo inhibitor, HhAntag, by whole animal functional imaging. HhAntag r... A conditional mouse model for malignant mesothelioma [作者：Jongsma, J; van Montfort, E; Vooijs, M; Zevenhoven, J; Krimpenfort, P; van der Valk, M; van de Vijver, M; Berns, A,期刊：Cancer Cell, 页码：261-271 , 文章类型： Article，,卷期：2008年13-3] Malignant mesothelioma is a devastating disease that has been associated with loss of Neurofibromatosis type 2 (NF2) and genetic lesions affecting RB and P53 pathways. We introduced similar lesions in the mesothelial lin... E2F1-regulated microRNAs impair TGF beta-dependent cell-cycle arrest and apoptosis in gastric cancer [作者：Petrocca, F; Visone, R; Onelli, MR; Shah, MH; Nicoloso, MS; de Martino, I; Iliopoulos, D; Pilozzi, E; Liu, CG; Negrini, M; Cavazzini, L; Volinia, S; Alder, H; Ruco, LP; Baldassarre, G; Croce, CM; Vecchione, A,期刊：Cancer Cell, 页码：272-286 , 文章类型： Article，,卷期：2008年13-3] Deregulation of E2F1 activity and resistance to TGF beta are hallmarks of gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs frequently misregulated in human malignancies. Here we provide evidence that the miR-1... Targeted anticancer therapies: Mouse models help uncover the mechanisms of tumor escape [作者：van Amerongen, R; Berns, A,期刊：Cancer Cell, 页码：287-287 , 文章类型： Correction，,卷期：2008年13-3] A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization [作者：Seandel, M; Butler, J; Lyden, D; Rafii, S,期刊：Cancer Cell, 页码：181-183 , 文章类型： Editorial Material，,卷期：2008年13-3] Small numbers of proangiogenic bone marrow-derived cells (BMDCs) can play pivotal roles in tumor progression. In this issue of Cancer Cell, two papers, utilizing different tumor angiogenesis models, both find that activa... Staying the distance: Avoiding the proteasomal trap [作者：Downes, M; Evans, RM,期刊：Cancer Cell, 页码：184-185 , 文章类型： Editorial Material，,卷期：2008年13-3] There are a multitude of nuclear receptor coactivators, and as a result, individual constituents of activation complexes are often overlooked when studying the specific actions of hormone signaling pathways. Specificity ... Learning the ABCs of melanoma-initiating cells [作者：Zabierowski, SE; Herlyn, M,期刊：Cancer Cell, 页码：185-187 , 文章类型： Editorial Material，,卷期：2008年13-3] Tumor stem or initiating cells have been proposed to exist for melanoma. Stem-like cells have been propagated from melanoma cell lines and specimens. Additionally, classical stem cell markers, including ABCG2 and CD133, ... The emerging role of the Hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals [作者：Zeng, Q; Hong, W,期刊：Cancer Cell, 页码：188-192 , 文章类型： Review，,卷期：2008年13-3] The Hippo pathway defined originally in Drosophila melanogaster is conserved in mammals. The fly core components Hippo, Sav, Wts, and Mats are conserved in mammals as Mst1/2, WW45, LATS1/2, and Mob1. The pathway impinges...