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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Survival of cancer cells is maintained by EGFR independent of its kinase activity [作者：Weihua, Z; Tsan, R; Huang, WC; Wu, Q; Chiu, CH; Fidler, IJ; Hung, MC,期刊：Cancer Cell, 页码：385-393 , 文章类型： Article，,卷期：2008年13-5] Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of... Regulation of in situ to invasive breast carcinoma transition [作者：Hu, M; Yao, J; Carroll, DK; Weremowicz, S; Chen, H; Carrasco, D; Richardson, A; Violette, S; Nikolskaya, T; Nikolsky, Y; Bauerlein, EL; Hahn, WC; Gelman, RS; Allred, C; Bissell, MJ; Schnitt, S; Polyak, K,期刊：Cancer Cell, 页码：394-406 , 文章类型： Article，,卷期：2008年13-5] The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression o... Transcription factor PROM induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype [作者：Petrova, TV; Nykanen, A; Norrmen, C; Ivanov, KI; Andersson, LC; Haglund, C; Puolakkainen, P; Wempe, F; von Melchner, H; Gradwohl, G; Vanharanta, S; Aaltonen, LA; Saharinen, J; Gentile, M; Clarke, A; Taipale, J; Oliver, G; Alitalo, K,期刊：Cancer Cell, 页码：407-419 , 文章类型： Article，,卷期：2008年13-5] The Drosophila transcription factor Prospero functions as a tumor suppressor, and it has been suggested that the human counterpart of Prospero, PROX1, acts similarly in human cancers. However, we show here that PROX1 pro... Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth [作者：Ryeom, S; Baek, KH; Rioth, MJ; Lynch, RC; Zaslavsky, A; Birsner, A; Yoon, SS; McKeon, F,期刊：Cancer Cell, 页码：420-431 , 文章类型： Article，,卷期：2008年13-5] The NF-AT transcription factors regulated by the phosphatase calcineurin play a role in breast cancer metastasis-promoting tumor cell invasion. Metastasis is a multistep process requiring angiogenesis and endothelial act... Malignant transformation initiated by MII-AF9: Gene dosage and critical target cells [作者：Chen, W; Kumar, AR; Hudson, WA; Li, Q; Wu, B; Staggs, RA; Lund, EA; Sam, TN; Kersey, JH,期刊：Cancer Cell, 页码：432-440 , 文章类型： Article，,卷期：2008年13-5] The pathways by which oncogenes, such as MLL-AF9, initiate transformation and leukemia in humans and mice are incompletely defined. In a study of target cells and oncogene dosage, we found that MII-AF9, when under endoge... Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer [作者：Stoecklein, NH; Hosch, SB; Bezler, M; Stern, F; Hartmann, CH; Vay, C; Siegmund, A; Scheunemann, P; Schurr, P; Knoefel, WT; Verde, PE; Reichelt, U; Erbersdobler, A; Grau, R; Ullrich, A; Izbicki, JR; Klein, CA,期刊：Cancer Cell, 页码：441-453 , 文章类型： Article，,卷期：2008年13-5] The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression. To address this problem, we studied the precursor cells of metastases... Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator [作者：Lain, S; Hollick, JJ; Campbell, J; Staples, OD; Higgins, M; Aoubala, M; McCarthy, A; Appleyard, V; Murray, KE; Baker, L; Thompson, A; Mathers, J; Holland, SJ; Stark, MJR; Pass, G; Woods, J; Lane, DP; Westwood, NJ,期刊：Cancer Cell, 页码：454-463 , 文章类型： Article，,卷期：2008年13-5] We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more wat... Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors (vol 13, pg 321, 2008) [作者：Geron, I; Abrahamsson, AE; Barroga, CF; Kavalerchik, E; Gotlib, J; Hood, JD; Durocher, J; Mak, CC; Noronha, G; Soll, RM; Tefferi, A; Kaushansky, K; Jamieson, CHM,期刊：Cancer Cell, 页码：464-464 , 文章类型： Correction，,卷期：2008年13-5] A sweet new role for EGFR in cancer [作者：Engelman, JA; Cantley, LC,期刊：Cancer Cell, 页码：375-376 , 文章类型： Editorial Material，,卷期：2008年13-5] The epidermal growth factor (EGFR) has served as an attractive bull's-eye for targeted cancer therapies. Although the importance of EGFR as an oncogenic tyrosine kinase seems well established, a report by Weihua et al. i... p53 activation: A case against sir [作者：Brooks, CL; Gu, W,期刊：Cancer Cell, 页码：377-378 , 文章类型： Editorial Material，,卷期：2008年13-5] The p53 tumor suppressor is a critical transcription factor for controlling cell growth and apoptosis during times of cellular stress. In this issue of Cancer Cell, Lain et al. have used a p53-responsive reporter gene as... PIKK-ing a new partner: A new role for PKB in the DNA damage response [作者：Lees-Miller, SP,期刊：Cancer Cell, 页码：379-380 , 文章类型： Editorial Material，,卷期：2008年13-5] The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase... How much REST is enough? [作者：Weissman, AM,期刊：Cancer Cell, 页码：381-383 , 文章类型： Editorial Material，,卷期：2008年13-5] Recent papers published in Nature by Guardavaccaro et al. and Westbrook et al. describe a nexus of two masters of negative regulation of protein levels. Both of these studies establish that the transcriptional repressor ...