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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共15条记录   Oxidative-Reductionist Approaches to Stem and Progenitor Cell Function [作者：Noble, M; Proschel, C; Mayer-Proschel, M,期刊：Cell Stem Cell, 页码：1-2 , 文章类型： Editorial Material，,卷期：2011年8-1] Redox status is a critical modulator of stem and progenitor cell function. In this issue of Cell Stem Cell, Le Belle et al. (2011) demonstrate that oxidation promotes self-renewal of neuroepithelial stem cells, revealing... Aging by Telomere Loss Can Be Reversed [作者：de Jesus, BB; Blasco, MA,期刊：Cell Stem Cell, 页码：3-4 , 文章类型： Editorial Material，,卷期：2011年8-1] Recently in Nature, Jaskelioff et al. (2010) demonstrated that multiple aging phenotypes in a mouse model of accelerated telomere loss can be reversed within 4 weeks of reactivating telomerase. This raises the major ques... HGPS-Derived iPSCs For The Ages [作者：Misteli, T,期刊：Cell Stem Cell, 页码：4-6 , 文章类型： Editorial Material，,卷期：2011年8-1] In this issue of Cell Stem Cell, Zhang et al. (2011) generate patient-derived iPSCs for one of the major premature aging diseases, Hutchinson-Gilford Progeria Syndrome (HGPS). These cells are a much-needed new tool to st... A Roundabout Way to the Niche [作者：Moore, K,期刊：Cell Stem Cell, 页码：6-7 , 文章类型： Editorial Material，,卷期：2011年8-1] A new player in hematopoietic stem cell (HSC)-niche interactions is introduced in this issue of Cell Stem Cell. Smith-Berdan et al. (2010) demonstrate that Robo4 is involved in HSC engraftment and mobilization and does s... There and Back Again: Hair Follicle Stem Cell Dynamics [作者：Fantauzzo, KA; Christiano, AM,期刊：Cell Stem Cell, 页码：8-9 , 文章类型： Editorial Material，,卷期：2011年8-1] Recently in Cell, Hsu et al. (2011) defined the relationship between stem cells and differentiated progeny within a hair follicle lineage. Their work reveals that stem cell descendants that have migrated out of the bulge... Transition of Endothelium to Cartilage and Bone [作者：Shoshani, O; Zipori, D,期刊：Cell Stem Cell, 页码：10-11 , 文章类型： Editorial Material，,卷期：2011年8-1] Mesenchymal stromal cells (MSCs) are capable of differentiating into bone-forming osteoblasts. A recent Nature Medicine study (Medici et al., 2010) shows that the mislocalized bone in the human disease fibrodisplasia oss... In Vitro Fertilization, the Nobel Prize, and Human Embryonic Stem Cells [作者：Gearhart, J; Coutifaris, C,期刊：Cell Stem Cell, 页码：12-15 , 文章类型： Editorial Material，,卷期：2011年8-1] Robert Edwards was awarded the 2010 Nobel Prize in Physiology or Medicine for the development of human in vitro fertilization. His work not only provided the means to overcome many forms of infertility, but it also enabl... DNA-Damage Response in Tissue-Specific and Cancer Stem Cells [作者：Blanpain, C; Mohrin, M; Sotiropoulou, PA; Passegue, E,期刊：Cell Stem Cell, 页码：16-29 , 文章类型： Review，,卷期：2011年8-1] Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body respond differentially to DNA damage. In this review, we will discuss how different SC populations sense and functionally respond ... A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects [作者：Zhang, JQ; Lian, QZ; Zhu, GL; Zhou, F; Sui, L; Tan, C; Mutalif, RA; Navasankari, R; Zhang, YL; Tse, HF; Stewart, CL; Colman, A,期刊：Cell Stem Cell, 页码：31-45 , 文章类型： Article，,卷期：2011年8-1] The segmental premature aging disease Hutchinson-Gilford Progeria syndrome (HGPS) is caused by a truncated and farnesylated form of Lamin A called progerin. HGPS affects mesenchymal lineages, including the skeletal syste... Calcineurin-NFAT Signaling Critically Regulates Early Lineage Specification in Mouse Embryonic Stem Cells and Embryos [作者：Li, XA; Zhu, LL; Yang, AC; Lin, JW; Tang, F; Jin, SB; Wei, Z; Li, JS; Jin, Y,期刊：Cell Stem Cell, 页码：46-58 , 文章类型： Article，,卷期：2011年8-1] Self-renewal and pluripotency are hallmarks of embryonic stem cells (ESCs). However, the signaling pathways that trigger their transition from self-renewal to differentiation remain elusive. Here, we report that calcineu... Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner [作者：Le Belle, JE; Orozco, NM; Paucar, AA; Saxe, JP; Mottahedeh, J; Pyle, AD; Wu, H; Kornblum, HI,期刊：Cell Stem Cell, 页码：59-71 , 文章类型： Article，,卷期：2011年8-1] The majority of research on reactive oxygen species (ROS) has focused on their cellular toxicities. Stem cells generally have been thought to maintain low levels of ROS as a protection against these processes. However, r... Robo4 Cooperates with Cxcr4 to Specify Hematopoietic Stem Cell Localization to Bone Marrow Niches [作者：Smith-Berdan, S; Nguyen, A; Hassanein, D; Zimmer, M; Ugarte, F; Ciriza, J; Li, D; Garcia-Ojeda, ME; Hinck, L; Forsberg, EC,期刊：Cell Stem Cell, 页码：72-83 , 文章类型： Article，,卷期：2011年8-1] Specific bone marrow (BM) niches are critical for hematopoietic stem cell (HSC) function during both normal hematopoiesis and in stem cell transplantation therapy. We demonstrate that the guidance molecule Robo4 function... EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila [作者：Jiang, HQ; Grenley, MO; Bravo, MJ; Blumhagen, RZ; Edgar, BA,期刊：Cell Stem Cell, 页码：84-95 , 文章类型： Article，,卷期：2011年8-1] Many tissues in higher animals undergo dynamic homeostatic growth, wherein damaged or aged cells are replaced by the progeny of resident stem cells. TO maintain homeostasis, stem cells must respond to tissue needs. Here ... Reprogramming Factor Expression Initiates Widespread Targeted Chromatin Remodeling [作者：Koche, RP; Smith, ZD; Adli, M; Gu, HC; Ku, MC; Gnirke, A; Bernstein, BE; Meissner, A,期刊：Cell Stem Cell, 页码：96-105 , 文章类型： Article，,卷期：2011年8-1] Despite rapid progress in characterizing transcription factor-driven reprogramming of somatic cells to an induced pluripotent stem cell (iPSC) state, many mechanistic questions still remain. To gain insight into the earl... Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture [作者：Laurent, LC; Ulitsky, I; Slavin, I; Tran, H; Schork, A; Morey, R; Lynch, C; Harness, JV; Lee, S; Barrero, MJ; Ku, S; Martynova, M; Semechkin, R; Galat, V; Gottesfeld, J; Belmonte, JCI; Murry, C; Keirstead, HS; Park, HS; Schmidt, U; Laslett, AL; Muller, FJ; Nievergelt, CM; Shamir, R; Loring, JF,期刊：Cell Stem Cell, 页码：106-118 , 文章类型： Article，,卷期：2011年8-1] Genomic stability is critical for the clinical use of human embryonic and induced pluripotent stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on 186 pluripotent and 119 nonpluripote...