- Primed for Pluripotency
[作者:Kunath, T,期刊:Cell Stem Cell, 页码:241-242 , 文章类型: Editorial Material,,卷期:2011年8-3]
- To date, pluripotent epiblast stem cells (EpiSCs) had only been derived from postimplantation mouse embryos. In this issue of Cell Stem Cell, Najm et al. (2011) demonstrate that EpiSCs can be routinely derived from preim...
- Clever Leukemic Stem Cells Branch Out
[作者:Vyas, P; Jacobsen, SEW,期刊:Cell Stem Cell, 页码:242-244 , 文章类型: Editorial Material,,卷期:2011年8-3]
- Individual tumors harbor heterogeneous populations of genetically distinct subclones. Two recent papers in Nature by Notta et al. (2011) and Anderson et al. (2011) reveal genetic heterogeneity in functional leukemic stem...
- Kidney Stem Cells Found in Adult Zebrafish
[作者:Zeng, XK; Hou, SX,期刊:Cell Stem Cell, 页码:247-249 , 文章类型: Editorial Material,,卷期:2011年8-3]
- Recently in Nature, Davidson and coworkers (Diep et al., 2011) identified nephron progenitors/stem cells located at the point of fusion with the pronephric tubules in adult zebrafish. Clumps of progenitors give rise to f...
- Biomimetic Platforms for Human Stem Cell Research
[作者:Vunjak-Novakovic, G; Scadden, DT,期刊:Cell Stem Cell, 页码:252-261 , 文章类型: Article,,卷期:2011年8-3]
- Stem cells are central to developing new treatment options for tissue regeneration and constructing controllable models for biological research. Bioengineered cell culture environments that combine microenvironmental con...
- Phosphoryl-EZH-ion
[作者:Caretti, G; Palacios, D; Sartorelli, V; Puri, PL,期刊:Cell Stem Cell, 页码:262-265 , 文章类型: Review,,卷期:2011年8-3]
- Polycomb group (PcG) proteins regulate gene expression in embryonic and adult stem cells, but the mechanisms responsible for PcG gene targeting and regulation remain largely unknown. Recent evidence shows that EZH2, the ...
- LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
[作者:Ha, NN; Byers, B; Cord, B; Shcheglovitov, A; Byrne, J; Gujar, P; Kee, K; Schule, B; Dolmetsch, RE; Langston, W; Palmer, TD; Pera, RR,期刊:Cell Stem Cell, 页码:267-280 , 文章类型: Article,,卷期:2011年8-3]
- Studies of Parkinson's disease (PD) have been hindered by lack of access to affected human dopaminergic (DA) neurons. Here, we report generation of induced pluripotent stem cells that carry the p.G2019S mutation (G2019S-...
- The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin
[作者:Smukler, SR; Arntfield, ME; Razavi, R; Bikopoulos, G; Karpowicz, P; Seaberg, R; Dai, FH; Lee, S; Ahrens, R; Fraser, PE; Wheeler, MB; van der Kooy, D,期刊:Cell Stem Cell, 页码:281-293 , 文章类型: Article,,卷期:2011年8-3]
- The search for putative precursor cells within the pancreas has been the focus of extensive research. Previously, we identified rare pancreas-derived multipotent precursor (PMP) cells in the mouse with the intriguing cap...
- Short-Term Immunosuppression Promotes Engraftment of Embryonic and Induced Pluripotent Stem Cells
[作者:Pearl, JI; Lee, AS; Leveson-Gower, DB; Sun, N; Ghosh, Z; Lan, F; Ransohoff, J; Negrin, RS; Davis, MM; Wu, JC,期刊:Cell Stem Cell, 页码:309-317 , 文章类型: Article,,卷期:2011年8-3]
- Embryonic stem cells (ESCs) are an attractive source for tissue regeneration and repair therapies because they can be differentiated into virtually any cell type in the adult body. However, for this approach to succeed, ...
- Isolation of Epiblast Stem Cells from Preimplantation Mouse Embryos
[作者:Najm, FJ; Chenoweth, JG; Anderson, PD; Nadeau, JH; Redline, RW; McKay, RDG; Tesar, PJ,期刊:Cell Stem Cell, 页码:318-325 , 文章类型: Article,,卷期:2011年8-3]
- Pluripotent stem cells provide a platform to interrogate control elements that function to generate all cell types of the body. Despite their utility for modeling development and disease, the relationship of mouse and hu...
- FGF2 Sustains NANOG and Switches the Outcome of BMP4-Induced Human Embryonic Stem Cell Differentiation
[作者:Yu, PZ; Pan, GJ; Yu, JY; Thomson, JA,期刊:Cell Stem Cell, 页码:326-334 , 文章类型: Article,,卷期:2011年8-3]
- Here, we show that as human embryonic stem cells (ESCs) exit the pluripotent state, NANOG can play a key role in determining lineage outcome. It has previously been reported that BMPs induce differentiation of human ESCs...
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