- Identification of heptapeptides interacting with IFN-alpha-sensitive CML cells
[作者:Liu, J; Chen, HC; Rao, ZZ; Khan, MA; Wan, XX; Xu, AH; Zhang, N; Zhang, DZ,期刊:Expert opinion on investigational drugs, 页码:1583-1589 , 文章类型: Article,,卷期:2011年20-12]
- Background: Interferon-alpha (IFN-alpha) is the traditional therapeutic agent for chronic myeloid leukemia (CML). The molecular mechanism of IFN-alpha efficacy in the treatment of CML is not fully clear.Objectives: To id...
- Adenosine receptor targeting in health and disease
[作者:Gessi, S; Merighi, S; Fazzi, D; Stefanelli, A; Varani, K; Borea, PA,期刊:Expert opinion on investigational drugs, 页码:1591-1609 , 文章类型: Review,,卷期:2011年20-12]
- Introduction: The adenosine receptors A(1), A(2A), A(2B) and A(3) are important and ubiquitous mediators of cellular signaling that play vital roles in protecting tissues and organs from damage. In particular, adenosine ...
- Several down, a few to go: histamine H(3) receptor ligands making the final push towards the market?
[作者:Kuhne, S; Wijtmans, M; Lim, HD; Leurs, R; de Esch, IJP,期刊:Expert opinion on investigational drugs, 页码:1629-1648 , 文章类型: Review,,卷期:2011年20-12]
- Introduction: The histamine H(3) receptor (H(3)R) plays a pivotal role in a plethora of therapeutic areas. Blocking the H(3)R with antagonists/inverse agonists has been postulated to be of broad therapeutic use. Indeed, ...
- The role of HGF/c-Met signaling in prostate cancer progression and c-Met inhibitors in clinical trials
[作者:Varkaris, A; Corn, PG; Gaur, S; Dayyani, F; Logothetis, CJ; Gallick, GE,期刊:Expert opinion on investigational drugs, 页码:1677-1684 , 文章类型: Review,,卷期:2011年20-12]
- Introduction: An increasing number of basic, translational and clinical studies demonstrate the importance of the protein tyrosine kinase receptor, c-Met, in the progression of prostate cancer. c-Met is overexpressed in ...
- Targeted therapy in sarcomas: mammalian target of rapamycin inhibitors from bench to bedside
[作者:Vincenzi, B; Napolitano, A; D'Onofrio, L; Frezza, AM; Silletta, M; Venditti, O; Santini, D; Tonini, G,期刊:Expert opinion on investigational drugs, 页码:1685-1705 , 文章类型: Review,,卷期:2011年20-12]
- Introduction: Sarcomas are rare heterogeneous malignancies of mesenchymal origin relatively common during childhood. Disruption of the mammalian target of rapamycin (mTOR) pathway is a very common event during the tumori...
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