- Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method
[作者:Verbaan, FJ; Bal, SM; van den Berg, DJ; Dijksman, JA; van Hecke, M; Verpoorten, H; van den Berg, A; Luttge, R; Bouwstra, JA,期刊:Journal of controlled release, 页码:80-88 , 文章类型: Article,,卷期:2008年128-1]
- An electrical applicator was designed, which can pierce short microneedles into the skin with a predefined velocity. Three different shapes of microneedles were used, namely 300 mu m assembled hollow metal microneedle ar...
- Functionalized micelles from block copolymer of polyphosphoester and poly(epsilon-caprolactone) for receptor-mediated drug delivery
[作者:Wang, YC; Liu, XQ; Sun, TM; Xiong, MH; Wang, J,期刊:Journal of controlled release, 页码:32-40 , 文章类型: Article,,卷期:2008年128-1]
- Cellular specific micellar systems from functional amphiphilic block copolymers are attractive for targeted intracellular drug delivery. In this study, we developed reactive micelles based on diblock copolymer of poly(et...
- Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles
[作者:Hwang, HY; Kim, IS; Kwon, IC; Kim, YH,期刊:Journal of controlled release, 页码:23-31 , 文章类型: Article,,卷期:2008年128-1]
- Hydrophobically modified glycol chitosan (HGC) nanoparticles, a new nano-sized drug carrier, were prepared by introducing a hydrophobic molecule, cholanic acid, to water soluble glycol chitosan. The HGC nanoparticles wer...
- Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents
[作者:Jin, T; Zhu, HH; Wu, F; Yuan, WE; Geng, LL; Zhu, H,期刊:Journal of controlled release, 页码:50-59 , 文章类型: Article,,卷期:2008年128-1]
- We report a method to load proteins into polymer-based sustained-release systems without exposing them to water-oil or water-air interfaces, factors known to denature proteins. By dispersing a dextan solution containing ...
- Molecular interactions, internal structure and drug release kinetics of rationally developed polymer-lipid hybrid nanoparticles
[作者:Li, YQ; Wong, HL; Shuhendler, AJ; Rauth, AM; Wu, MY,期刊:Journal of controlled release, 页码:60-70 , 文章类型: Article,,卷期:2008年128-1]
- This paper presents the first study of molecular interactions of ingredients and internal nanostructure in relation to drug loading and release mechanisms/kinetics of rationally designed solid polymer-lipid hybrid nanopa...
- In vivo time-dependent gene expression of cationic lipid-based emulsion as a stable and biocompatible non-viral gene carrier
[作者:Kwon, SM; Nam, HY; Nam, T; Park, K; Lee, S; Kim, K; Kwon, IC; Kim, J; Kang, D; Park, JH; Jeong, SY,期刊:Journal of controlled release, 页码:89-97 , 文章类型: Article,,卷期:2008年128-1]
- To make stable and biocompatible non-viral gene carriers for therapeutic gene therapy, we developed a cationic lipid-based emulsion (CLE) prepared by an oil-in-water (O/W) emulsion method, wherein squalene oil was used a...
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