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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   Reawakening Atlas: Chemical Approaches To Repair or Replace Dysfunctional Musculature [作者：JUNG DAWOON; WILLIAMS DARREN R,期刊：ACS CHEMICAL BIOLOGY, 页码：1773-1790 , 文章类型： Review，,卷期：2012年7-11] Muscle diseases are major health concerns. For example, ischemic heart disease is the third most common cause of death. Cell therapy is an attractive approach for treating muscle diseases, although this is hampered by th... Non-proteinogenic Amino Acids in Lacticin 481 Analogues Result in More Potent Inhibition of Peptidoglycan Transglycosylation [作者：KNERR PATRICK J; OMAN TRENT J; DE GONZALO CHANTAL V GARCIA; LUPOLI TANIA J; WALKER SUZANNE; VAN DER DONK WILFRED A,期刊：ACS CHEMICAL BIOLOGY, 页码：1791-1795 , 文章类型： Article，,卷期：2012年7-11] Lantibiotics are ribosomally synthesized and;post-translationally modified peptide natural products that contain the thioether structures lanthionine and methyllanthionine and exert potent antimicrobial activity against ... Synthetic Allergen Design Reveals the Significance of Moderate Affinity Epitopes in Mast Cell Degranulation [作者：HANDLOGTEN MICHAEL W; KIZILTEPE TANYEL; ALVES NATHAN J; BILGICER BASAR,期刊：ACS CHEMICAL BIOLOGY, 页码：1796-1801 , 文章类型： Article，,卷期：2012年7-11] This study describes the design of a well-defined homotetravalent synthetic allergen (HTA) system to investigate the effect of hapten-IgE interactions on mast cell degranulation. A library of DNP variants with varying af... Programming a Highly Structured Ribozyme into Complex Allostery Using RNA Oligonucleotides [作者：ROULEAU SAMUEL G; JODOIN RACHEL; BISAILLON MARTIN; PERREAULT JEANPIERRE,期刊：ACS CHEMICAL BIOLOGY, 页码：1802-1806 , 文章类型： Article，,卷期：2012年7-11] RNA possesses great potential for expanding the toolbox currently available to synthetic biologists. Here, the modulation of the Hepatitis Delta Virus ribozyme's activity with a series of rationally designed aptamers and... Comparative Genomics Guided Discovery of Two Missing Archaeal Enzyme Families Involved in the Biosynthesis of the Pterin Moiety of Tetrahydromethanopterin and Tetrahydrofolate [作者：DE CRECYLAGARD VALERIE; PHILLIPS GABRIELA; GROCHOWSKI LAURA L; EL YACOUBI BASMA; JENNEY FRANCIS; ADAMS MICHAEL W W; MURZIN ALEXEY G; WHITE ROBERT H,期刊：ACS CHEMICAL BIOLOGY, 页码：1807-1816 , 文章类型： Article，,卷期：2012年7-11] C-1 carriers are essential cofactors in all domains of life, and in Archaea, these can be derivatives of tetrahydromethanopterin (H-4-MPT) or tetrahydrofolate (H-4-folate). Their synthesis requires 6-hydroxymethyl-7,8-di... Construction of a Rhythm Transfer System That Mimics the Cellular Clock [作者：IMANISHI MIKI; YAMAMOTO KAZUTOSHI; YAMADA HIROYUKI; HIROSE YUKA; OKAMURA HITOSHI; FUTAKI SHIROH,期刊：ACS CHEMICAL BIOLOGY, 页码：1817-1821 , 文章类型： Article，,卷期：2012年7-11] Creation of an artificial oscillating gene expression. system is one of the most challenging issues in synthetic biology. Here, we constructed a simple system to manipulate gene expression patterns to be circadian, refle... De Novo Engineering of a Human Cystathionine-gamma-Lyase for Systemic L-Methionine Depletion Cancer Therapy [作者：STONE EVERETT; PALEY OLGA; HU JIAN; EKERDT BARBARA; CHEUNG NAIKONG; GEORGIOU GEORGE,期刊：ACS CHEMICAL BIOLOGY, 页码：1822-1829 , 文章类型： Article，,卷期：2012年7-11] It been known for nearly a half century that human tumors, including those derived from the nervous system such as glioblastomas, medulloblastoma, and neuroblastomas are much more sensitive than normal tissues to L-methi... Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility [作者：THAL DAVID M; HOMAN KRISTOFF T; CHEN JUN; WU EMILY K; HINKLE PATRICIA M; HUANG Z MAGGIE; CHUPRUN J KURT; SONG JIANLIANG; GAO ERHE; CHEUNG JOSEPH Y; SKLAR LARRY A; KOCH WALTER J; TESMER JOHN J G,期刊：ACS CHEMICAL BIOLOGY, 页码：1830-1839 , 文章类型： Article，,卷期：2012年7-11] G protein-coupled receptor kinase 2 (GRK2) is a well-established therapeutic target for the treatment of heart,failure. Herein we identify the Selective: serotonin reuptake inhibitor.(SSRI) paroxetine as a selective inhi... Uncoupling Intramolecular Processing and Substrate Hydrolysis in the N-Terminal Nucleophile Hydrolase hASRGL1 by Circular Permutation [作者：LI WENZONG; CANTOR JASON R; YOGESHA S D; YANG SHIRLEY; CHANTRANUPONG LYNNE; LIU JUNE QINGXIA; AGNELLO GIULIA; GEORGIOU GEORGE; STONE EVERETT M; ZHANG YAN,期刊：ACS CHEMICAL BIOLOGY, 页码：1840-1847 , 文章类型： Article，,卷期：2012年7-11] The human asparaginase-like protein 1 (hASRGL1) catalyzes the hydrolysis of L-asparagine and isoaspartyl-dipeptides As an N-terminal nucleophile (Ntn) hydrolase superfamily member, the active form of hASRGL1 is generated... Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate [作者：HALL MARY P; UNCH JAMES; BINKOWSKI BROCK F; VALLEY MICHAEL P; BUTLER BRAEDEN L; WOOD MONIKA G; OTTO PAUL; ZIMMERMAN KRISTOPHER; VIDUGIRIS GEDIMINAS; MACHLEIDT THOMAS; ROBERS MATTHEW B; BENINK HELENE A; EGGERS CHRISTOPHER T; SLATER MICHAEL R; MEISENHEIMER PONCHO L; KLAUBERT DIETER H; FAN FRANK; ENCELL LANCE P; WOOD KEITH V,期刊：ACS CHEMICAL BIOLOGY, 页码：1848-1857 , 文章类型： Article，,卷期：2012年7-11] Bioluminescence methodologies have been extraordinarily useful :due to their high sensitivity, broad: dynamic range, and operational simplicity. These capabilities have been realized largely through incremental adaptatio... Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei [作者：URBANIAK MICHAEL D; MATHIESON TOBY; BANTSCHEFF MARCUS; EBERHARD DIRK; GRIMALDI RAFFAELLA; MIRANDASAAVEDRA DIEGO; WYATT PAUL; FERGUSON MICHAEL A J; FREARSON JULIE; DREWES GERARD,期刊：ACS CHEMICAL BIOLOGY, 页码：1858-1865 , 文章类型： Article，,卷期：2012年7-11] The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness, and there is an urgent unmet need for improved treatments. Parasite protein kinases are attractive drug targets, provided tha... In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound [作者：KEATING THOMAS A; NEWMAN JOSEPH V; OLIVIER NELSON B; OTTERSON LINDA G; ANDREWS BETH; BORIACKSJODIN P ANN; BREEN JOHN N; DOIG PETER; DUMAS JACQUES; GANGL ERIC; GREEN OLUYINKA M; GULER SATENIG Y; HENTEMANN MARTIN F; JOSEPHMCCARTHY DIANE; KAWATKAR SAMEER; KUTSCHKE AMY; LOCH JAMES T; MCKENZIE ANDREW R; PRADEEPAN SELVI; PRASAD SWATI; MARTINEZBOTELLA GABRIEL,期刊：ACS CHEMICAL BIOLOGY, 页码：1866-1872 , 文章类型： Article，,卷期：2012年7-11] There is an urgent need for new antibacterials that pinpoint novel targets and thereby avoid existing resistance mechanisms. We have created novel synthetic antibacterials through structure-based drug design that specifi... Manipulating JNK Signaling with (-)-Zuonin A [作者：KAOUD TAMER S; PARK HEEKWANG; MITRA SHREYA; YAN CHUNLI; TSENG CHUNCHIA; SHI YUE; JOSE JINEY; TALIAFERRO JULIANA M; LEE KIYOUN; REN PENGYU; HONG JIYONG; DALBY KEVIN N,期刊：ACS CHEMICAL BIOLOGY, 页码：1873-1883 , 文章类型： Article，,卷期：2012年7-11] Recently, in a virtual screening strategy to identify new compounds targeting the D-recruitment site (DRS) of the c-Jun N-terminal kinases (JNKs), we identified the natural product (-)-zuonin A. Here we report the asymme... Real-Time Noninvasive Imaging of Fatty Acid Uptake in Vivo [作者：HENKIN AMY H; COHEN ALLISON S; DUBIKOVSKAYA ELENA A; PARK HYO MIN; NIKITIN GENNADY F; AUZIAS MATHIEU G; KAZANTZIS MELISSA; BERTOZZI CAROLYN R; STAHL ANDREAS,期刊：ACS CHEMICAL BIOLOGY, 页码：1884-1891 , 文章类型： Article，,卷期：2012年7-11] Detection and quantification of fatty acid fluxes in animal model systems following physiological, pathological, or pharmacological challenges is key to our understanding of complex metabolic networks as these macronutri... Comparative Chemogenomics To Examine the Mechanism of Action of DNA-Targeted Platinum-Acridine Anticancer Agents [作者：CHEUNGONG KAHLIN; SONG KYUNG TAE; MA ZHIDONG; SHABTAI DANIEL; LEE ANNA Y; GALLO DAVID; HEISLER LAWRENCE E; BROWN GRANT W; BIERBACH ULRICH; GIAEVER GURI; NISLOW COREY,期刊：ACS CHEMICAL BIOLOGY, 页码：1892-1901 , 文章类型： Article，,卷期：2012年7-11] Platinum-based drugs have been used to successfully treat diverse cancers for several decades. Cisplatin, the original compound of this class, cross-links. DNA, resulting in cell cycle arrest and cell death via apoptosis... Probing a 2-Aminobenzimidazole Library for Binding to RNA Internal Loops via Two-Dimensional Combinatorial Screening [作者：VELAGAPUDI SAI PRADEEP; PUSHECHNIKOV ALEXEI; LABUDA LUCAS P; FRENCH JONATHAN M; DISNEY MATTHEW D,期刊：ACS CHEMICAL BIOLOGY, 页码：1902-1909 , 文章类型： Article，,卷期：2012年7-11] There are many potential RNA drug targets in bacterial, viral, and human transcriptomes. However, there are few small molecules that modulate RNA function. This is due, in part, to a lack of fundamental understanding abo...