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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   A Win for Bioorthogonal Chemistry [作者：SOARES JITESH,期刊：ACS CHEMICAL BIOLOGY, 页码：781-782 , 文章类型： Editorial Material，,卷期：2012年7-5] The Three Cornerstones of Chemical Biology: Innovative Probes, New Discoveries, and Enabling Tools [作者：THOMPSON ANDREA D; MAKLEY LEAH N; MCMENIMEN KATHRYN; GESTWICKI JASON E,期刊：ACS CHEMICAL BIOLOGY, 页码：791-796 , 文章类型： Editorial Material，,卷期：2012年7-5] Redesign of Glycopeptide Antibiotics: Back to the Future [作者：JAMES ROBERT C; PIERCE JOSHUA G; OKANO AKINORI; XIE JIAN; BOGER DALE L,期刊：ACS CHEMICAL BIOLOGY, 页码：797-804 , 文章类型： Article，,卷期：2012年7-5] The glycopeptide antibiotics are the most important class of drugs used in the treatment of resistant bacterial infections including those caused by methicillin-resistant Staphylococcus aureus (MRSA). After more than 50 ... Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification [作者：LIU FA; PARK JUNGEUN; QIAN WENJIAN; LIM DAN; SCHAROW ANDREJ; BERG THORSTEN; YAFFE MICHAEL B; LEE KYUNG S; BURKE TERRENCE R JR,期刊：ACS CHEMICAL BIOLOGY, 页码：805-810 , 文章类型： Article，,卷期：2012年7-5] In an effort to develop improved binding antagonists of the polo-like kinase 1 (Plk1) polo-box domain (PBD), we optimized interactions of the known high affinity 5-mer peptide PLHSpT using oxime,based post solid-phase pe... The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508 [作者：BAUMLI SONJA; HOLE ALISON J; NOBLE MARTIN E M; ENDICOTT JANE A,期刊：ACS CHEMICAL BIOLOGY, 页码：811-816 , 文章类型： Article，,卷期：2012年7-5] CDK9 is the kinase of positive transcription elongation factor b and facilitates the transition of paused RNA polymerase II to processive transcription elongation. CDK9 is a validated target for the treatment of cancer, ... Bicyclic Peptide Inhibitor Reveals Large Contact Interface with a Protease Target [作者：ANGELINI ALESSANDRO; CENDRON LAURA; CHEN SHIYU; TOUATI JEREMY; WINTER GREG; ZANOTTI GIUSEPPE; HEINIS CHRISTIAN,期刊：ACS CHEMICAL BIOLOGY, 页码：817-821 , 文章类型： Article，,卷期：2012年7-5] From a large combinatorial library of chemically constrained bicyclic peptides we isolated a selective and potent (K-i = 53 nM) inhibitor of human urokinase-type plasminogen activator (uPA) and crystallized the complex. ... A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery [作者：MILLS STEPHEN J; PERSSON CAMILLA; COZIER GYLES; THOMAS MARK P; TRESAUGUES LIONEL; ERNEUX CHRISTOPHE; RILEY ANDREW M; NORDLUND PAR; POTTER BARRY V L,期刊：ACS CHEMICAL BIOLOGY, 页码：822-828 , 文章类型： Article，,卷期：2012年7-5] Phosphoinositides regulate many cellular processes, and cellular levels are controlled by kinases and phosphatases. SHIP2 (SH2 (Src homology 2)-domain-containing inositol-phosphatase-2) plays a critical role in phosphoin... Glycan Fingerprints: Calculating Diversity in Glycan Libraries [作者：RADEMACHER CHRISTOPH; PAULSON JAMES C,期刊：ACS CHEMICAL BIOLOGY, 页码：829-834 , 文章类型： Article，,卷期：2012年7-5] Carbohydrate libraries printed in glycan micorarray format have had a great impact on the high-throughput analysis of the specificity of a wide range of mammalian, plant, and bacterial lectins. Chemical and chemo-enzymat... A High-Throughput Screen for the Engineered Production of beta-Lactam Antibiotics [作者：PHELAN RYAN M; DIPARDO BENJAMIN J; TOWNSEND CRAIG A,期刊：ACS CHEMICAL BIOLOGY, 页码：835-840 , 文章类型： Article，,卷期：2012年7-5] High-throughput screens and selections have had profound impact on our ability to engineer proteins possessing new, desired properties. These methods are especially useful when applied to the modification of existing enz... Probing the Effects of Residues Located Outside the Agonist Binding Site on Drug-Receptor Selectivity in the Nicotinic Receptor [作者：PUSKAR NYSSA L; LESTER HENRY A; DOUGHERTY DENNIS A,期刊：ACS CHEMICAL BIOLOGY, 页码：841-846 , 文章类型： Article，,卷期：2012年7-5] The nicotinic acetylcholine receptors (nAChRs) are a family of closely related but pharmacologically distinct neurotransmitter-gated ion channels. They are therapeutic targets for a wide range of neurological disorders, ... Amide Analogues of CD1d Agonists Modulate iNKT-Cell-Mediated Cytokine Production [作者：WOJNO JUSTYNA; JUKES JOHNPAUL; GHADBANE HEMZA; SHEPHERD DAWN; BESRA GURDYAL S; CERUNDOLO VINCENZO; COX LIAM R,期刊：ACS CHEMICAL BIOLOGY, 页码：847-855 , 文章类型： Article，,卷期：2012年7-5] Invariant natural killer T (iNKT) cells are restricted by the non-polymorphic MHC class I-like protein, CD1d, and activated following presentation of lipid antigens bound to CD1d molecules. The prototypical iNKT cell ago... Rationally Designed Small Molecules Targeting the RNA That Causes Myotonic Dystrophy Type 1 Are Potently Bioactive [作者：CHILDSDISNEY JESSICA L; HOSKINS JASON; RZUCZEK SUZANNE G; THORNTON CHARLES A; DISNEY MATTHEW D,期刊：ACS CHEMICAL BIOLOGY, 页码：856-862 , 文章类型： Article，,卷期：2012年7-5] RNA is an important drug target, but it is difficult to design or discover small molecules that modulate RNA function. In the present study, we report that rationally designed, modularly assembled small molecules that bi... Sulfolipid-1 Biosynthesis Restricts Mycobacterium tuberculosis Growth in Human Macrophages [作者：GILMORE SARAH A; SCHELLE MICHAEL W; HOLSCLAW CYNTHIA M; LEIGH CLIFTON D; JAIN MADHULIKA; COX JEFFERY S; LEARY JULIE A; BERTOZZI CAROLYN R,期刊：ACS CHEMICAL BIOLOGY, 页码：863-870 , 文章类型： Article，,卷期：2012年7-5] Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is a highly evolved human pathogen characterized by its formidable cell wall. Many unique lipids and glycolipids from the Mtb cell wall are thought t... Role of Pseudouridine in Structural Rearrangements of Helix 69 During Bacterial Ribosome Assembly [作者：SAKAKIBARA YOGO; CHOW CHRISTINE S,期刊：ACS CHEMICAL BIOLOGY, 页码：871-878 , 文章类型： Article，,卷期：2012年7-5] As part of the central core domain of the ribosome, helix 69 of 23S rRNA participates in an important intersubunit bridge and contacts several protein translation factors. Helix 69 is believed to play key roles in protei... Small-Molecule Inhibitors of Bacterial AddAB and RecBCD Helicase-Nuclease DNA Repair Enzymes [作者：AMUNDSEN SUSAN K; SPICER TIMOTHY; KARABULUT AHMET C; LONDONO LUZ MARINA; EBERHART CHRISTINA; VEGA VIRNELIZ FERNANDEZ; BANNISTER THOMAS D; HODDER PETER; SMITH GERALD R,期刊：ACS CHEMICAL BIOLOGY, 页码：879-891 , 文章类型： Article，,卷期：2012年7-5] The AddAB and RecBCD helicase-nucleases are related enzymes prevalent among bacteria but not eukaryotes and are instrumental in the repair of DNA double-strand breaks and in genetic recombination. Although these enzymes ... Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein [作者：SASAZAWA YUKIKO; KANAGAKI SHUHEI; TASHIRO ETSU; NOGAWA TOSHIHIKO; MUROI MAKOTO; KONDOH YASUMITSU; OSADA HIROYUKI; IMOTO MASAYA,期刊：ACS CHEMICAL BIOLOGY, 页码：892-900 , 文章类型： Article，,卷期：2012年7-5] Autophagy is a bulk, nonspecific protein degradation pathway that is involved in the pathogenesis of cancer and neurodegenerative disease. Here, we observed that xanthohumol (XN), a prenylated chalcone present in hops (H...