- Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors
[作者:Singer, AU; Wu, B; Yee, A; Houliston, S; Xu, XH; Cui, H; Skarina, T; Garcia, M; Semesi, A; Arrowsmith, CH; Savchenko, A,期刊:Biochemistry, 页码:1-3 , 文章类型: Article,,卷期:2012年51-1]
- HopPmaL is a member of the HopAB family of type III effectors present in the phytopathogen Pseudomonas syringae. Using both X-ray crystallography and solution nuclear magnetic resonance, we demonstrate that HopPmaL conta...
- Quantifying the Kinetic Stability of Hyperstable Proteins via Time-Dependent SDS Trapping
[作者:Xia, K; Zhang, SJ; Bathrick, B; Liu, SQ; Garcia, Y; Colon, W,期刊:Biochemistry, 页码:100-107 , 文章类型: Article,,卷期:2012年51-1]
- Globular proteins are usually in equilibrium with unfolded conformations, whereas kinetically stable proteins (KSPs) are conformationally trapped by their high unfolding transition state energy. Kinetic stability (KS) co...
- A beta(39-42) Modulates A beta Oligomerization but Not Fibril Formation
[作者:Gessel, MM; Wu, C; Li, HY; Bitan, G; Shea, JE; Bowers, MT,期刊:Biochemistry, 页码:108-117 , 文章类型: Article,,卷期:2012年51-1]
- Recently, certain C-terminal fragments (CTFs) of A beta 42 have been shown to be effective inhibitors of A beta 42 toxicity. Here, we examine the interactions between the shortest CTF in the original series, A beta(39-42...
- Hydrophobicity and Conformational Change as Mechanistic Determinants for Nonspecific Modulators of Amyloid beta Self-Assembly
[作者:Abelein, A; Bolognesi, B; Dobson, CM; Graslund, A; Lendel, C,期刊:Biochemistry, 页码:126-137 , 文章类型: Article,,卷期:2012年51-1]
- The link between many neurodegenerative disorders, including Alzheimer's and Parkinson's diseases, and the aberrant folding and aggregation of proteins has prompted a comprehensive search for small organic molecules that...
- Ultrafast Ligand Dynamics in the Heme-Based GAF Sensor Domains of the Histidine Kinases DosS and DosT from Mycobacterium tuberculosis
[作者:Vos, MH; Bouzhir-Sima, L; Lambry, JC; Luo, H; Eaton-Rye, JJ; Ioanoviciu, A; de Montellano, PRO; Liebl, U,期刊:Biochemistry, 页码:159-166 , 文章类型: Article,,卷期:2012年51-1]
- The transcriptional regulator DosR from M. tuberculosis plays a crucial role in the virulence to dormancy transition of the pathogen. DosR can be activated by DosT and DosS, two histidine kinases with heme-containing sen...
- A "Sliding Scale Rule" for Selectivity among NO, CO, and O(2) by Heme Protein Sensors
[作者:Tsai, AL; Berka, V; Martin, E; Olson, JS,期刊:Biochemistry, 页码:172-186 , 文章类型: Article,,卷期:2012年51-1]
- Selectivity among NO, CO, and O(2) is crucial for the physiological function of most heme proteins. Although there is a million-fold variation in equilibrium dissociation constants (K(D)), the ratios for NO:CO:O(2) bindi...
- Rifampicin-Independent Interactions between the Pregnane X Receptor Ligand Binding Domain and Peptide Fragments of Coactivator and Corepressor Proteins
[作者:Navaratnarajah, P; Steele, BL; Redinbo, MR; Thompson, NL,期刊:Biochemistry, 页码:19-31 , 文章类型: Article,,卷期:2012年51-1]
- The pregnane X receptor (PXR), a member of the nuclear receptor superfamily, regulates the expression of drug-metabolizing enzymes in a ligand-dependent manner. The conventional view of nuclear receptor action is that li...
- Regulation of Urokinase Expression at the Posttranscription Level by Lung Epithelial Cells
[作者:Shetty, SK; Marudamuthu, AS; Abernathy, D; Shetty, RS; Shetty, P; Fu, J; Idell, S; Bhandary, YP; Ji, HL; Liu, MC; Shetty, S,期刊:Biochemistry, 页码:205-213 , 文章类型: Article,,卷期:2012年51-1]
- Urokinase-type plasminogen activator (uPA) is expressed by lung epithelial cells and regulates fibrin turnover and epithelial cell viability. PMA, LPS, and TNF-alpha, as well as uPA itself', induce uPA expression in lung...
- Post-Translational Modifications of the Serotonin Type 4 Receptor Heterologously Expressed in Mouse Rod Cells
[作者:Salom, D; Wang, BL; Dong, ZQ; Sun, WY; Padayatti, P; Jordan, S; Salon, JA; Palczewski, K,期刊:Biochemistry, 页码:214-224 , 文章类型: Article,,卷期:2012年51-1]
- G-Protein-coupled serotonin receptor type 4 (5-HT(4)R) is a pharmacological target implicated in a variety of gastrointestinal and nervous system disorders. As for many other integral membrane proteins, structural and fu...
|