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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共15条记录   Discontinued drugs in 2008: endocrine and metabolic [作者：Colca, JR,期刊：Expert opinion on investigational drugs, 页码：1243-1255 , 文章类型： Article，,卷期：2009年18-9] This perspective summarizes key compounds from the endocrine and metabolic area that were discontinued during the calendar year 2008. This is a continuation in a series of perspectives of each of the editorial areas summ... Rosiglitazone maleate plus metformin a hydrochloride extend: review of an emerging compound [作者：Cheng, AYY; Josse, RG,期刊：Expert opinion on investigational drugs, 页码：1365-1373 , 文章类型： Editorial Material，,卷期：2009年18-9] Clinical practice guidelines from around the world have continued to highlight the importance of glycemic control in the prevention of diabetes complications. Despite the many tools available to achieve these targets, it... Retaspimycin hydrochloride (IPI-504): a novel heat shock protein inhibitor as an anticancer agent [作者：Hanson, BE; Vesole, DH,期刊：Expert opinion on investigational drugs, 页码：1375-1383 , 文章类型： Editorial Material，,卷期：2009年18-9] Heat shock proteins are vital to cell survival under conditions of stress. They bind client proteins to assist in protein stabilization, translocation of polypeptides across cell membranes and recovery of proteins from a... A fixed dose combination of ibuprofen and famotidine [作者：Birk, JW; Myers, M,期刊：Expert opinion on investigational drugs, 页码：1385-1391 , 文章类型： Editorial Material，,卷期：2009年18-9] The NSAID class of medications is frequently used for mild to moderate pain. While overall safe, NSAIDs have several important adverse effects including esophageal, gastric and duodenal ulceration which limit their use. ... Anidulafungin and voriconazole in invasive fungal disease: pharmacological data and their use in combination [作者：Perkhofer, S; Lass-Florl, C,期刊：Expert opinion on investigational drugs, 页码：1393-1404 , 文章类型： Editorial Material，,卷期：2009年18-9] The incidence of invasive fungal infections has been increasing since the 1980s due to a growing population of immunocompromised and critically ill patients with associated risk factors including immunosuppressive chemot... Taspoglutide: a long acting human glucagon-like polypeptide-1 analogue [作者：Retterstol, K,期刊：Expert opinion on investigational drugs, 页码：1405-1411 , 文章类型： Editorial Material，,卷期：2009年18-9] Background: Taspogluticle (R1583/BIM51077) is a new anti diabetic drug from Hoffmann-La Roche. The compound is to be administered as a subcutaneous injection once weekly and is also effective given bi-weekly. It is a lon... Corticorelin acetate injections for the treatment of peritumoral brain edema [作者：Moliterno, JA; Henry, E; Pannullo, SC,期刊：Expert opinion on investigational drugs, 页码：1413-1419 , 文章类型： Editorial Material，,卷期：2009年18-9] Background: The use of corticosteroids has been shown to be effective in the management of vasogenic edema caused by brain tumors, and is currently the standard of care. The associated systemic side effects, however, can... Golimumab for severe asthma [作者：Antoniu, SA,期刊：Expert opinion on investigational drugs, 页码：1421-1423 , 文章类型： Editorial Material，,卷期：2009年18-9] Backgorund: In severe asthma anti-TNF-alpha therapies might be effective in improving disease control based on preclinical results and on clinical short-term data. However, the long-term efficacy and safety is not known.... Novel inhibitors of the PI3K family [作者：Carnero, A,期刊：Expert opinion on investigational drugs, 页码：1265-1277 , 文章类型： Review，,卷期：2009年18-9] PI3K is an important node regulating the signaling of several essential biological processes. PI3K catalyzes the phosphorylation in position 3 of the inositol ring of phosphaticlyl-inositide producing important lipid sec... New generation azole antifungals in clinical investigation [作者：Girmenia, C,期刊：Expert opinion on investigational drugs, 页码：1279-1295 , 文章类型： Review，,卷期：2009年18-9] Considerable progress in treating systemic mycoses has been achieved in the past years through development of new drugs in association with more advanced diagnostic procedures. Here, we review the pharmacological, microb... Somatostatin and somatostatin receptors: implications for neoplastic growth and cancer biology [作者：Msaouel, P; Galanis, E; Koutsilieris, M,期刊：Expert opinion on investigational drugs, 页码：1297-1316 , 文章类型： Review，,卷期：2009年18-9] Somatostatin agonists (SM-As) are capable of achieving durable symptomatic relief and significant clinical responses in certain tumours. Herein, we review the diverse direct and indirect mechanisms of antineoplastic acti... Platelet P2Y12 receptor inhibition by thienopyridines: status and future [作者：Porto, I; Giubilato, S; De Maria, GL; Blasucci, LM; Crea, F,期刊：Expert opinion on investigational drugs, 页码：1317-1332 , 文章类型： Review，,卷期：2009年18-9] Thienopyridines have a well-established role in the treatment of coronary artery disease, especially in the setting of acute coronary syndromes and percutaneous coronary interventions. Ticlopidine, the first FDA-approved... Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia [作者：Martelli, AM; Evangelisti, C; Chiarini, F; Grimaldi, C; Manzoli, L; McCubrey, JA,期刊：Expert opinion on investigational drugs, 页码：1333-1349 , 文章类型： Review，,卷期：2009年18-9] Background: The PI3K/Akt/mammalian target of rapamycin (mTOR) signaling pathway plays a central role in cell growth, proliferation and survival not only under physiological conditions but also in a variety of tumor cells... Novel targets in esophageal and gastric cancer: beyond antiangiogenesis [作者：Lee, W; Patel, JH; Lockhart, AC,期刊：Expert opinion on investigational drugs, 页码：1351-1364 , 文章类型： Review，,卷期：2009年18-9] Cancers of the stomach, gastroesophageal junction and esophagus are a major cause of cancer-related deaths worldwide. In Western countries, adenocarcinomas of the distal esophagus, gastroesophageal junction and proximal ... Is there a palliative benefit of gemcitabine plus fluoropyrimidines in patients with refractory colorectal cancer? A review of the literature [作者：Merl, MY; Hoimes, CJ; Pham, T; Saif, MW,期刊：Expert opinion on investigational drugs, 页码：1257-1264 , 文章类型： Review，,卷期：2009年18-9] Introduction: Fluoropyrimidines with oxaliplatin or irinotecan plus bevacizumab is the standard chemotherapy combination in patients with advanced colorectal cancer (CRC). Gemcitabine acts synergistically with fluoropyri...