- Synthesis, antitubercular activity and docking study of novel cyclic azole substituted diphenyl ether derivatives
[作者:Kini, SG; Bhat, AR; Bryant, B; Williamson, JS; Dayan, FE,期刊:European Journal of Medicinal Chemistry, 页码:492-500 , 文章类型: Article,,卷期:2009年44-2]
- The re-emergence of tuberculosis (TB) as a global health problem over the past few decades, accompanied by the rise of drug-resistant strains of Mycobacterium tuberculosis, emphasizes the need for discovery of new therap...
- Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents
[作者:Ertan, T; Yildiz, I; Tekiner-Gulbas, B; Bolelli, K; Temiz-Arpaci, O; Ozkan, S; Kaynak, F; Yalcin, I; Aki, E,期刊:European Journal of Medicinal Chemistry, 页码:501-510 , 文章类型: Article,,卷期:2009年44-2]
- A new series of 5(or 6)-nitro/amino-2-(substituted phenyl/benzyl)benzoxazole derivatives (1a-1m, 2a-21) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus s...
- Synthesis and biological evaluation of a new family of anti-benzylanilinosulfonamides as CA IX inhibitors
[作者:Thiry, A; Delayen, A; Goossens, L; Houssin, R; Ledecq, M; Frankart, A; Dogne, JM; Wouters, J; Supuran, CT; Henichart, JP; Masereel, B,期刊:European Journal of Medicinal Chemistry, 页码:511-518 , 文章类型: Article,,卷期:2009年44-2]
- We report the synthesis and the pharmacological evaluation of a new class of human carbonic anhydrase (hCA) inhibitors prepared regio- and stereoselectively by reacting sulfanilamide with ethyl trans-phenylglycidate in t...
- Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues
[作者:Liang, G; Yang, SL; Zhou, HP; Shao, LL; Huang, KX; Xiao, J; Huang, ZF; Li, XK,期刊:European Journal of Medicinal Chemistry, 页码:915-919 , 文章类型: Article,,卷期:2009年44-2]
- Curcuminoids have been reported to possess multifunctional bioactivities, especially the ability to inhibit proinflammatory induction. Since it has been suggested that the seven-carbon beta-diketone linker in curcumin is...
- (+/-)-3,4-Dihydroxy-8,9-methylenedioxypterocarpan and derivatives: Cytotoxic effect on human leukemia cell lines
[作者:Netto, CD; Santos, ESJ; Castro, CP; da Silva, AJM; Rumjanek, VM; Costa, PRR,期刊:European Journal of Medicinal Chemistry, 页码:920-925 , 文章类型: Article,,卷期:2009年44-2]
- Naturally occurring pterocarpans 1a,b, pterocarpan 1c, isoflavane 2 and ortho-quinone 3 were synthesized in the racemic form and their totoxic effect was evaluated on the human leukemia cell lines K562 (resistant to oxid...
- New derivatives of 3,5-substituted-1,4,2-dioxazoles: Synthesis and activity against Entamoeba histolytica
[作者:Bhat, AR; Athar, F; Azam, A,期刊:European Journal of Medicinal Chemistry, 页码:926-936 , 文章类型: Article,,卷期:2009年44-2]
- Dioxazole derivatives (1-33) were synthesized in two steps via their corresponding oximes (I-III). All the compounds were characterized using various spectroscopic techniques. A comparative study of in vitro antiamoebic ...
- Synthesis and in vitro cytotoxic evaluation of novel 3,4, 5-trimethoxyphenyl substituted beta-carboline derivatives
[作者:Wu, QF; Cao, RH; Feng, MX; Guan, XD; Ma, CM; Liu, JB; Song, HC; Peng, WL,期刊:European Journal of Medicinal Chemistry, 页码:533-540 , 文章类型: Article,,卷期:2009年44-2]
- To elucidate further our SARs' study on the chemistry and cytotoxic activity and probe the structural requirement for the potent antitumor activity of beta-carbolines, a series of novel 1,9-disubstituted and 1,3,9-trisub...
- Novel derivatives of 6-mercaptopurine: Synthesis, characterization and antiproliferative activities of S-allylthio-mercaptopurines
[作者:Miron, T; Arditti, F; Konstantinovski, L; Rabinkov, A; Mirelman, D; Berrebi, A; Wilchek, M,期刊:European Journal of Medicinal Chemistry, 页码:541-550 , 文章类型: Article,,卷期:2009年44-2]
- Biologically active S-allylthio derivatives of 6-mercaptopurine (6-MP) and 6-mercaptopurine riboside (6-MPR) were synthesized. The products, S-allylthio-6-mercaptopurine (SA-6MP) and S-allylthio-6-mercaptopurine riboside...
- Synthesis and antimicrobial activities of some new triazolothiadiazoles bearing 4-methylthiobenzyl moiety
[作者:Prasad, DJ; Ashok, M; Karegoudar, P; Poojary, B; Holla, BS; Kumari, NS,期刊:European Journal of Medicinal Chemistry, 页码:551-557 , 文章类型: Article,,卷期:2009年44-2]
- A series of substituted triazolothiadiazoles (6a-j and 7a-j) have been synthesized by condensing 4-amino-3-[4-methylthiobenzyl]-4H-1,2,4-triazole-5-thiol (5) with substituted aryl furoic acids/aromatic acids in the prese...
- Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: Synthesis, structure-activity relationship, and action mechanism studies
[作者:Moret, V; Laras, Y; Cresteil, T; Aubert, G; Ping, DQ; Di, C; Barthelemy-Requin, M; Beclin, C; Peyrot, V; Allegro, D; Rolland, A; De Angelis, F; Gatti, E; Pierre, P; Pasquini, L; Petrucci, E; Testa, U; Kraus, JL,期刊:European Journal of Medicinal Chemistry, 页码:558-567 , 文章类型: Article,,卷期:2009年44-2]
- Bis-8-hydroxyquinoline substituted benzylamines have been synthesized and screened for their antitumor activity on KB3 cell line model. Synthesis of this series of new analogues was accomplished using a one pot specific ...
- Synthesis and spectral characterization of a new class of N-(N-methylpiperazinoacetyl)-2,6-diarylpiperidin-4-ones: Antimicrobial, analgesic and antipyretic studies
[作者:Aridoss, G; Parthiban, R; Ramachandran, R; Prakash, M; Kabilan, S; Jeong, YT,期刊:European Journal of Medicinal Chemistry, 页码:577-592 , 文章类型: Article,,卷期:2009年44-2]
- A series of N-(N-methylpiperazinoacetyl)-2,6-diarylpiperidin-4-ones (13c-21c) were synthesized by the base catalyzed nucleophilic substitution of N-chloroacetyl-2,6-diarylpiperidin-4-ones obtained from their correspondin...
- Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CBI): Development of ligands with optimized lipophilicity and binding affinity
[作者:Fan, H; Kotsikorou, E; Hoffman, AF; Ravert, HT; Holt, D; Hurst, DP; Lupica, CR; Reggio, PH; Dannals, RF; Horti, AG,期刊:European Journal of Medicinal Chemistry, 页码:593-608 , 文章类型: Article,,卷期:2009年44-2]
- Cyano analogs of Rimonabant with high binding affinity for the cerebral cannabinoid receptor (CB1) and with optimized lipophilicity have been synthesized as potential positron emission tomography (PET) ligands. The best ...
- Design and synthesis of azolopyrimidoquinolines, pyrimidoquinazolines as anti-oxidant, anti-inflammatory and analgesic activities
[作者:El-Gazzar, ABA; Youssef, MM; Youssef, AMS; Abu-Hashem, AA; Badria, FA,期刊:European Journal of Medicinal Chemistry, 页码:609-624 , 文章类型: Article,,卷期:2009年44-2]
- The 5,10-dihydro-2-thioxo-pyrimido[4,5-b]quinolines (2a-c) and its oxidized form 3 were prepared and used as key intermediates for the synthesis of thiazolo[3',2':1,2]pyrimido[4,5-b]-quinolines (5a-c), isoxazolo[5 '',4 '...
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