- Novel amide derivatives as inhibitors of histone deacetylase: Design, synthesis and SAR
[作者:Andrianov, V; Gailite, V; Lola, D; Loza, E; Semenikhina, V; Kalvinsh, I; Finn, P; Petersen, KD; Ritchie, JWA; Khan, N; Tumber, A; Collins, LS; Vadlamudi, SM; Bjorkling, F; Sehested, M,期刊:European Journal of Medicinal Chemistry, 页码:1067-1085 , 文章类型: Article,,卷期:2009年44-3]
- Enzymatic inhibition of histone deacetylase (HDAC) activity is emerging as an innovative and effective approach for the treatment of cancer. A series of novel amide derivatives have been synthesized and evaluated for the...
- 2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6, 11-diones and related compounds: Synthesis and Biological evaluation as potential antiproliferative and antifungal agents
[作者:Tandon, VK; Maurya, HK; Tripathi, A; ShivaKeshava, GB; Shukla, PK; Srivastava, P; Panda, D,期刊:European Journal of Medicinal Chemistry, 页码:1086-1092 , 文章类型: Article,,卷期:2009年44-3]
- A series of 2-chloro-3-arylsulfanyl-[1,4]naphthoquinones (2), 2,3-bis-arylsulfanyl-[1,4]naphthoquinones (3) and 12H-benzo[b]phenothiazine-6,11-diones and their analogs 6-8 were synthesized and evaluated for their antipro...
- Synthesis, characterization and antimicrobial activity of water soluble dendritic macromolecules
[作者:Tulu, M; Aghatabay, NM; Senel, M; Dizman, C; Parali, T; Dulger, B,期刊:European Journal of Medicinal Chemistry, 页码:1093-1099 , 文章类型: Article,,卷期:2009年44-3]
- Several families of water soluble dendrimers were synthesized based on poly (propyleneoxide) amines (Jeffamines (R)) (PI). PI-core and branched units were constructed from both methylacrylate and ethylenediamine (P-2-P-9...
- Synthesis and anticonvulsant activity of some substituted 1.2,4-thiadiazoles
[作者:Gupta, A; Mishra, P; Pandeya, SN; Kashaw, SK; Kashaw, V; Stables, JP,期刊:European Journal of Medicinal Chemistry, 页码:1100-1105 , 文章类型: Article,,卷期:2009年44-3]
- A series of new substituted 1,2,4-thiadiazoles were synthesized by appropriate route and screened for anticonvulsant, neurotoxic and sedative-hypnotic activity. The structures of the synthesized compounds were confirmed ...
- N-Acylated and N,N '-diacylated imidazolidine-2-thione derivatives and N,N '-diacylated tetrahydropyrimidine-2(1H)-thione analogues: Synthesis and antiproliferative activity
[作者:Cesarini, S; Spallarossa, A; Ranise, A; Schenone, S; Rosano, C; La Colla, P; Sanna, G; Busonera, B; Loddo, R,期刊:European Journal of Medicinal Chemistry, 页码:1106-1118 , 文章类型: Article,,卷期:2009年44-3]
- Fifty-one acylthioureas (ATUs) incorporating imidazolidine-2-thione or its upper cyclohomologue were prepared by parallel synthesis and evaluated against a high number of human cancer cell lines for antiproliferative act...
- Synthesis of some new 4-styryltetrazolo[1,5-a]quinoxaline and 1-substituted-4-styryl[1,2,4]triazolo[4,3-a]quinoxaline derivatives as potent anticonvulsants
[作者:Wagle, S; Adhikari, AV; Kumari, NS,期刊:European Journal of Medicinal Chemistry, 页码:1135-1143 , 文章类型: Article,,卷期:2009年44-3]
- 4-Methyltetrazolo[1,5-a]quinoxaline (3) was prepared by the azide cyclocondensation of 2-chloro-3-methylquinoxaline (2). The reaction of 3 with aromatic aldehydes furnished 4-styryltetrazolo[1,5-a]quinoxalines (4a-f). Co...
- A set of new amino acid descriptors applied in prediction of MHC class I binding peptides
[作者:Liang, GZ; Yang, L; Chen, ZC; Mei, H; Shu, M; Li, ZL,期刊:European Journal of Medicinal Chemistry, 页码:1144-1154 , 文章类型: Article,,卷期:2009年44-3]
- A set of new amino acid descriptors, namely factor analysis scales of generalized amino acid information (FASGAI) involving hydrophobicity, alpha and turn propensities, bulky properties, compositional characteristics, lo...
- Structure-based virtual screening for identification of novel 11 beta-HSD1 inhibitors
[作者:Yang, HY; Shen, Y; Chen, JH; Jiang, QF; Leng, Y; Shen, JH,期刊:European Journal of Medicinal Chemistry, 页码:1167-1171 , 文章类型: Article,,卷期:2009年44-3]
- Structure-based pharmacophore models were built by using LigandScout and used for virtual screening of the SPECS database to identify new potential 11 beta-HSD1 inhibitors. As a refinement of the results obtained from vi...
- Synthesis of modified pyrimidine bases and positive impact of chemically reactive substituents on their in vitro antiproliferative activity
[作者:Noll, S; Kralj, M; Suman, L; Stephan, H; Piantanida, I,期刊:European Journal of Medicinal Chemistry, 页码:1172-1179 , 文章类型: Article,,卷期:2009年44-3]
- The antiproliferative activity screening on human tumor cell lines of a series of modified uracil and cytosine bases as well as some corresponding acyclonucleosides, and comparison of structure-activity relationship reve...
- Predicting anti-HIV activity of 1,3,4-thiazolidinone derivatives: 3D-QSAR approach
[作者:Ravichandran, V; Kumar, BRP; Sankar, S; Agrawal, RK,期刊:European Journal of Medicinal Chemistry, 页码:1180-1187 , 文章类型: Article,,卷期:2009年44-3]
- HIV-1 (human immunodeficiency virus type-1) is the pathogenic retrovirus and causative agent of AIDS. HIV-1 is one of the key enzymes in the duplication of HIV-1. Inhibitors of HIV-1 RT are classified as NNRTIs and NRTIs...
- Antimicrobial studies of some novel quinazolinones fused with [1,2,4]-triazole, [1,2,4]-triazine and [1,2,4,5]-tetrazine rings
[作者:Pandey, SK; Singh, A; Singh, A; Nizamuddin,期刊:European Journal of Medicinal Chemistry, 页码:1188-1197 , 文章类型: Article,,卷期:2009年44-3]
- Three series of novel and new fused heterocyclic systems, viz. triazolo[4,3-a]-quinazolin-7-ones (4), [1,2,4,5]-tetrazino[4,3-a]-quinazolin-8-ones (6) and indolo[2,3-c][1,2,4]-triazino[4,3-a]-quinazolin-8-ones (8) have b...
- Adamantane derivatives of thiazolyl-N-substituted amide, as possible non-steroidal anti-inflammatory agents
[作者:Kouatly, O; Geronikaki, A; Kamoutsis, C; Hadjipavlou-Litina, D; Eleftheriou, P,期刊:European Journal of Medicinal Chemistry, 页码:1198-1204 , 文章类型: Article,,卷期:2009年44-3]
- A series of adamantane derivatives of thiazolyl-N-substituted amides were synthesized in a three-step reaction and tested for anti-inflammatory activity as well as lipoxygenase and cycloxygenase inhibitory actions. Theor...
- Synthesis and antibacterial activity of nitroaryl thiadiazole-gatifloxacin hybrids
[作者:Jazayeri, S; Moshafi, MH; Firoupour, L; Emami, S; Rajabalian, S; Haddad, M; Pahlavanzadeh, F; Esnaashari, M; Shafiee, A; Foroumadi, A,期刊:European Journal of Medicinal Chemistry, 页码:1205-1209 , 文章类型: Article,,卷期:2009年44-3]
- A number of gatifloxacin analogues containing a nitroaryl-1,3,4-thiadiazole moiety attached to the piperazine ring at C-7 position were prepared and evaluated as antibacterial agents against a panel of Gram-positive and ...
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