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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共56条记录   Synthesis, kinase inhibitory potencies and in vitro antiproliferative activity of isoindigo and 7 '-azaisoindigo derivatives substituted by Sonogashira cross-coupling [作者：Bouchikhi, F; Anizon, F; Moreau, P,期刊：European Journal of Medicinal Chemistry, 页码：2705-2710 , 文章类型： Article，,卷期：2009年44-6] In the course of structure-activity relationship studies we were interested in the synthesis of isoindigo and 7'-azaisoindigo derivatives substituted at the N-1 position by a 1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranos... Synthesis of benzamide derivatives of anacardic acid and their cytotoxic activity [作者：Chandregowda, V; Kush, A; Reddy, GC,期刊：European Journal of Medicinal Chemistry, 页码：2711-2719 , 文章类型： Article，,卷期：2009年44-6] Several benzamide derivatives were synthesized from anacardic acid (1a) which was the product of hydrogenation of the naturally occurring anacardic acid mixture (1a-d), a major constituent of cashew nut shell liquid. Ana... Antitumour activity of novel 1,10-phenanthroline and 5-amino-1,10-phenanthroline derivatives [作者：Wesselinova, D; Neykov, M; Kaloyanov, N; Toshkova, R; Dimitrov, G,期刊：European Journal of Medicinal Chemistry, 页码：2720-2723 , 文章类型： Article，,卷期：2009年44-6] Synthesis and impact on the tumour growth of palladium(II) complex of 5-amino-1,10-phenanthroline Pd(5-NH2-phen)(2)(NO3)(2) and the protonated dimer (phen)(2)(H+)(BF4-) have been described. In the reported experiments a ... Structure-activity relationships for dipeptide prodrugs of acyclovir: Implications for prodrug design [作者：Santos, CR; Capela, R; Pereira, CSGP; Valente, E; Gouveia, L; Pannecouque, C; De Clercq, E; Moreira, R; Gomes, P,期刊：European Journal of Medicinal Chemistry, 页码：2339-2346 , 文章类型： Article，,卷期：2009年44-6] A series of water-soluble dipeptide ester prodrugs of the antiviral acyclovir (ACV) were evaluated for their chemical stability, cytotoxicity, and antiviral activity against several strains of Herpes Simplex-1 and -2, va... Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives [作者：Sharma, D; Narasimhan, B; Kumar, P; Judge, V; Narang, R; De Clercq, E; Balzarini, J,期刊：European Journal of Medicinal Chemistry, 页码：2347-2353 , 文章类型： Article，,卷期：2009年44-6] In the present study, we have synthesized 2-(substituted phenyl)-1H-imidazole (1-12) and (substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanone (13-26) analogues and screened them for their antimicrobial a... Classification models for CYP450 3A4 inhibitors and non-inhibitors [作者：Choi, I; Kim, SY; Kim, H; Kang, NS; Bae, MA; Yoo, SE; Jung, J; No, KT,期刊：European Journal of Medicinal Chemistry, 页码：2354-2360 , 文章类型： Article，,卷期：2009年44-6] Cytochrome P450 3A4 (CYP3A4) is the predominant enzyme involved in the oxidative metabolic pathways of many drugs. The inhibition of this enzyme in many cases leads to an undesired accumulation of the administered therap... Synthesis and antioxidant potential of novel synthetic benzophenone analogues [作者：Tzanova, T; Gerova, M; Petrov, O; Karaivanova, M; Bagrel, D,期刊：European Journal of Medicinal Chemistry, 页码：2724-2730 , 文章类型： Article，,卷期：2009年44-6] Considering that oxidative stress is strongly implicated in the toxicity of chemotherapy, much effort is focused on the research of diverse antioxidants as protective agents. An efficient synthesis of three novel benzoph... New antimalarial and cytotoxic 4-nerolidylcatechol derivatives [作者：Pinto, ACD; Silva, LFR; Cavalcanti, BC; Melo, MRS; Chaves, FCM; Lotufo, LVC; de Moraes, MO; de Andrade-Neto, VF; Tadei, WP; Pessoa, CO; Vieira, PPR; Pohlit, AM,期刊：European Journal of Medicinal Chemistry, 页码：2731-2735 , 文章类型： Article，,卷期：2009年44-6] 4-Nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a multigram scale using straight-forward solvent extraction-column chromatography. New semi-synthetic derivatives of I were prepared and te... The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines [作者：Chan, SH; Lam, KH; Chui, CH; Gambari, R; Yuen, MCW; Wong, RSM; Cheng, GYM; Lau, FY; Au, YK; Cheng, CH; Lai, PBS; Kan, CW; Kok, SHL; Tang, JCO; Chan, ASC,期刊：European Journal of Medicinal Chemistry, 页码：2736-2740 , 文章类型： Article，,卷期：2009年44-6] The 'one pot' condensation reaction for the synthesis and potent anti proliferative inhibition of alpha-phthalimide based ketones is reported here. 2-Phthalimide-1-(4-fluoro-phenyl)ethanone (5) showed the best growth inh... Hybrid molecules between benzenesulfonamides and active antimicrobial benzo[d]isothiazol-3-ones [作者：Zani, F; Incerti, M; Ferretti, R; Vicini, P,期刊：European Journal of Medicinal Chemistry, 页码：2741-2747 , 文章类型： Article，,卷期：2009年44-6] Novel hybrid molecules between benzenesulfonamides and active antimicrobial 2-amino-benzo[d]isothiazol-3-ones were synthesized and characterised and their in vitro antimicrobial activity was evaluated by the minimal inhi... Fragment and knowledge-based design of selective GSK-3 beta inhibitors using virtual screening models [作者：Vadivelan, S; Sinha, BN; Tajne, S; Jagarlapudi, SARP,期刊：European Journal of Medicinal Chemistry, 页码：2361-2371 , 文章类型： Article，,卷期：2009年44-6] Glycogen Synthase Kinase 3 beta is one of the important targets in the treatment of type II diabetes and Alzheimer's disease. Currently this target is in pursuit for type II diabetes and a few GSK-3 beta inhibitors have ... Aroylpropionic acid based 2,5-disubstituted-1,3,4-oxadiazoles: Synthesis and their anti-inflammatory and analgesic activities [作者：Akhter, M; Husain, A; Azad, B; Ajmal, M,期刊：European Journal of Medicinal Chemistry, 页码：2372-2378 , 文章类型： Article，,卷期：2009年44-6] Synthesis and biological evaluation of various aroylpropionic acid derivatives containing 1,3,4-Oxadiazole nucleus is reported here. The compounds (3a-w) were synthesized by cyclizabon of 3-aroylpropionic acids into 1,3,... Substituted quinazolines, part 3. Synthesis, in vitro antitumor activity and molecular modeling study of certain 2-thieno-4(3H)-quinazolinone analogs [作者：Al-Obaid, AM; Abdel-Hamide, SG; El-Kashef, HA; Abdel-Aziz, AAM; El-Azab, AS; Al-Khamees, HA; El-Subbagh, HI,期刊：European Journal of Medicinal Chemistry, 页码：2379-2391 , 文章类型： Article，,卷期：2009年44-6] The synthesis of some new 2-thieno-4(3H)-quinazolinone derivatives and their biological evaluation as antitumor agents using the National Cancer Institute (NCI) disease oriented antitumor screen protocol are investigated... Synthesis of [C-11]FEDAA1106 as a new PET imaging probe of peripheral benzodiazepine receptor expression [作者：Wang, M; Gao, MZ; Hutchins, GD; Zheng, QH,期刊：European Journal of Medicinal Chemistry, 页码：2748-2753 , 文章类型： Article，,卷期：2009年44-6] Peripheral benzodiazepine receptor (PBR) is associated with neuroinflammation and tumor progression. [C-11]DAA1106 and [F-18]FEDAA1106 are two promising radioligands for positron emission tomography (PET) imaging of PBR.... Anti-genotoxic hydrazide from Crinum defixum [作者：Bordoloi, M; Kotoky, R; Mahanta, JJ; Sarma, TC; Kanjilal, PB,期刊：European Journal of Medicinal Chemistry, 页码：2754-2757 , 文章类型： Article，,卷期：2009年44-6] Crinum defixum Ker-Gawl popularly known as Bon-naharu (meaning wild garlic) in Assam. It is found abundantly growing wild on riverbanks of Dhansiri River in Golaghat District of Assam. It is used as ethnomedicine in this... Synthesis, characterization and cytotoxicity of ammine/ethylamine platinum(II) complexes with carboxylates [作者：Zhang, JC; Li, YP; Sun, J,期刊：European Journal of Medicinal Chemistry, 页码：2758-2762 , 文章类型： Article，,卷期：2009年44-6] Six new mixed ammine/ethylamine platinum(II) complexes with carboxylates [Pt(II)(NH3)(C2H5NH2)X-2] (a-f) (X=CH3COO-, CH2ClCOO-, C6H5-COO-, p-CH3-C6H4-COO-, p-CH3O-C6H4-COO-, p-NO2-C6H4-COO-) (a-f) have been synthesized a...