- On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
[作者：WHITE TINA R; RENZELMAN CHAD M; RAND ARTHUR C; REZAI TAHA; MCEWEN CAYLA M; GELEV VLADIMIR M; TURNER RUSHIA A; LININGTON ROGER G; LEUNG SIEGFRIED S F; KALGUTKAR AMIT S; BAUMAN JONATHAN N; ZHANG YIZHONG; LIRAS SPIROS; PRICE DAVID A; MATHIOWETZ ALAN M; JACOBSON MATTHEW P; LOKEY R SCOTT,期刊：NATURE CHEMICAL BIOLOGY, 页码：810-817 , 文章类型： Article，,卷期：2011年7-11]
- Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides. However, the specific impact of N-methylation...
- Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
[作者：MOULICK KAMALIKA; AHN JAMES H; ZONG HONGLIANG; RODINA ANNA; CERCHIETTI LEANDRO; DAGAMA ERICA M GOMES; CALDASLOPES ELOISI; BEEBE KRISTIN; PERNA FABIANA; HATZI KATERINA; VU LY P; ZHAO XINYANG; ZATORSKA DANUTA; TALDONE TONY; SMITHJONES PETER; ALPAUGH MARY; GROSS STEVEN S; PILLARSETTY NAGAVARAKISHORE; KU THOMAS; LEWIS JASON S; LARSON STEVEN M; LEVINE ROSS; ERDJUMENTBROMAGE HEDIYE; GUZMAN MONICA L; NIMER STEPHEN D; MELNICK ARI; NECKERS LEN; CHIOSIS GABRIELA,期刊：NATURE CHEMICAL BIOLOGY, 页码：818-826 , 文章类型： Article，,卷期：2011年7-11]
- Most cancers are characterized by multiple molecular alterations, but identification of the key proteins involved in these signaling pathways is currently beyond reach. We show that the inhibitor PU-H71 preferentially ta...
- The proteoglycan bikunin has a defined sequence
[作者：LY MELLISA; LEACH FRANKLIN E III; LAREMORE TATIANA N; TOIDA TOSHIHIKO; AMSTER I JONATHAN; LINHARDT ROBERT J,期刊：NATURE CHEMICAL BIOLOGY, 页码：827-833 , 文章类型： Article，,卷期：2011年7-11]
- Proteoglycans are complex glycoconjugates that regulate critical biological pathways in all higher organisms. Bikunin, the simplest proteoglycan, with a single glycosaminoglycan chain, is a serine protease inhibitor used...
- Chemical inhibitors of monogalactosyldiacylglycerol synthases in Arabidopsis thaliana
[作者：BOTTE CYRILLE Y; DELIGNY MICHAEL; ROCCIA AYMERIC; BONNEAU ANNELAURE; SAIDANI NADIA; HARDRE HELENE; ACI SAMIA; YAMARYOBOTTE YOSHIKI; JOUHET JULIETTE; DUBOTS EMMANUELLE; LOIZEAU KAREN; BASTIEN OLIVIER; BREHELIN LAURENT; JOYARD JACQUES; CINTRAT JEANCHRISTOPHE; FALCONET DENIS; BLOCK MARYSE A; ROUSSEAU BERNARD; LOPEZ ROMAN; MARECHAL ERIC,期刊：NATURE CHEMICAL BIOLOGY, 页码：834-842 , 文章类型： Article，,卷期：2011年7-11]
- Monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG) are the main lipids in photosynthetic membranes in plant cells. They are synthesized in the envelope surrounding plastids by MGD and DGD galactosy...
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