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  • Multiple ligand-specific conformations of the beta(2)-adrenergic receptor
    [作者:KAHSAI ALEM W; XIAO KUNHONG; RAJAGOPAL SUDARSHAN; AHN SEUNGKIRL; SHUKLA ARUN K; SUN JINPENG; OAS TERRENCE G; LEFKOWITZ ROBERT J,期刊:NATURE CHEMICAL BIOLOGY, 页码:692-700 , 文章类型: Article,,卷期:2011年7-10]
  • Seven-transmembrane receptors (7TMRs), also called G protein-coupled receptors (GPCRs), represent the largest class of drug targets, and they can signal through several distinct mechanisms including those mediated by G p...
  • TRPA1 underlies a sensing mechanism for O(2)
    [作者:TAKAHASHI NOBUAKI; KUWAKI TOMOYUKI; KIYONAKA SHIGEKI; NUMATA TOMOHIRO; KOZAI DAISUKE; MIZUNO YUSUKE; YAMAMOTO SHINICHIRO; NAITO SHINJI; KNEVELS ELLEN; CARMELIET PETER; OGA TORU; KANEKO SHUJI; SUGA SEIJI; NOKAMI TOSHIKI; YOSHIDA JUNICHI; MORI YASUO,期刊:NATURE CHEMICAL BIOLOGY, 页码:701-711 , 文章类型: Article,,卷期:2011年7-10]
  • Oxygen (O(2)) is a prerequisite for cellular respiration in aerobic organisms but also elicits toxicity. To understand how animals cope with the ambivalent physiological nature of O(2), it is critical to elucidate the mo...
  • Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor
    [作者:MATA MIGUEL A; SATTERLY NEAL; VERSTEEG GIJS A; FRANTZ DOUG; WEI SHUGUANG; WILLIAMS NOELLE; SCHMOLKE MIRCO; PENALLOPIS SAMUEL; BRUGAROLAS JAMES; FORST CHRISTIAN V; WHITE MICHAEL A; GARCIASASTRE ADOLFO; ROTH MICHAEL G; FONTOURA BEATRIZ M A,期刊:NATURE CHEMICAL BIOLOGY, 页码:712-719 , 文章类型: Article,,卷期:2011年7-10]
  • A chemical genetics approach was taken to identify inhibitors of NS1, a major influenza A virus virulence factor that inhibits host gene expression. A high-throughput screen of 200,000 synthetic compounds identified smal...