个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   Made to measure [作者：ANONYMOUS,期刊：NATURE CHEMICAL BIOLOGY, 页码：575-575 , 文章类型： Editorial Material，,卷期：2011年7-9] Caught in a spectroscopic trap [作者：PIEHLER JACOB,期刊：NATURE CHEMICAL BIOLOGY, 页码：578-579 , 文章类型： News Item，,卷期：2011年7-9] Redox and adhesion on the rocks [作者：WILKER JONATHAN J,期刊：NATURE CHEMICAL BIOLOGY, 页码：579-580 , 文章类型： News Item，,卷期：2011年7-9] FlAsH illuminates A beta aggregation [作者：OUTEIRO TIAGO F,期刊：NATURE CHEMICAL BIOLOGY, 页码：581-582 , 文章类型： News Item，,卷期：2011年7-9] Nature-inspired total synthesis [作者：FURST LAURA; STEPHENSON COREY R J,期刊：NATURE CHEMICAL BIOLOGY, 页码：582-583 , 文章类型： News Item，,卷期：2011年7-9] An orthosteric inhibitor of the Ras-Sos interaction [作者：PATGIRI ANUPAM; YADAV KAMLESH K; ARORA PARAMJIT S; BARSAGI DAFNA,期刊：NATURE CHEMICAL BIOLOGY, 页码：585-587 , 文章类型： Article，,卷期：2011年7-9] Mimics of alpha-helices on protein surfaces have emerged as powerful reagents for antagonizing protein-protein interactions, which are difficult to target with small molecules. Here we describe the design of a cell-perme... Mussel protein adhesion depends on interprotein thiol-mediated redox modulation [作者：YU JING; WEI WEI; DANNER ERIC; ASHLEY REBEKAH K; ISRAELACHVILI JACOB N; WAITE J HERBERT,期刊：NATURE CHEMICAL BIOLOGY, 页码：588-590 , 文章类型： Article，,卷期：2011年7-9] Mussel adhesion is mediated by foot proteins (mfps) rich in a catecholic amino acid, 3,4-dihydroxyphenylalanine (dopa), capable of forming strong bidentate interactions with a variety of surfaces. A tendency toward facil... The second Phytophthora mating hormone defines interspecies biosynthetic crosstalk [作者：OJIKA MAKOTO; MOLLI SHYLAJA D; KANAZAWA HARUMI; YAJIMA ARATA; TODA KOU; NUKADA TOMOO; MAO HAIMENG; MURATA RYO; ASANO TOMOYO; QI JIANHUA; SAKAGAMI YOUJI,期刊：NATURE CHEMICAL BIOLOGY, 页码：591-593 , 文章类型： Article，,卷期：2011年7-9] The heterothallic species of the agricultural pest Phytophthora use mating hormones alpha 1 and alpha 2 to regulate their sexual reproduction. Here we describe the absolute stereostructure of the second mating hormone al... Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel [作者：LIU FA; PARK JUNGEUN; QIAN WENJIAN; LIM DAN; GRAEBER MARTIN; BERG THORSTEN; YAFFE MICHAEL B; LEE KYUNG S; BURKE TERRENCE R JR,期刊：NATURE CHEMICAL BIOLOGY, 页码：595-601 , 文章类型： Article，,卷期：2011年7-9] We obtained unanticipated synthetic byproducts from alkylation of the delta(1) nitrogen (N3) of the histidine imidazole ring of the polo-like kinase-1 (Plk1) polo-box domain (PBD)-binding peptide PLHSpT. For the highest-... Amyloid-beta forms fibrils by nucleated conformational conversion of oligomers [作者：LEE JIYONG; CULYBA ELIZABETH K; POWERS EVAN T; KELLY JEFFERY W,期刊：NATURE CHEMICAL BIOLOGY, 页码：602-609 , 文章类型： Article，,卷期：2011年7-9] Amyloid-beta amyloidogenesis is reported to occur via a nucleated polymerization mechanism. If this is true, the energetically unfavorable oligomeric nucleus should be very hard to detect. However, many laboratories have... Chemical genetics identify eIF2 alpha kinase heme-regulated inhibitor as an anticancer target [作者：CHEN TING; OZEL DUYGU; QIAO YUAN; HARBINSKI FRED; CHEN LIMO; DENOYELLE SEVERINE; HE XIAOYING; ZVEREVA NELA; SUPKO JEFFREY G; CHOREV MICHAEL; HALPERIN JOSE A; AKTAS BERTAL H,期刊：NATURE CHEMICAL BIOLOGY, 页码：610-616 , 文章类型： Article，,卷期：2011年7-9] Translation initiation plays a critical role in cellular homeostasis, proliferation, differentiation and malignant transformation. Consistently, increasing the abundance of the eIF2-GTP-tRNA(i)(Met) translation initiatio... Contributions of counter-charge in a potassium channel voltage-sensor domain [作者：PLESS STEPHAN A; GALPIN JASON D; NICIFOROVIC ANA P; AHERN CHRISTOPHER A,期刊：NATURE CHEMICAL BIOLOGY, 页码：617-623 , 文章类型： Article，,卷期：2011年7-9] Voltage-sensor domains couple membrane potential to conformational changes in voltage-gated ion channels and phosphatases. Highly coevolved acidic and aromatic side chains assist the transfer of cationic side chains acro... CODA-RET reveals functional selectivity as a result of GPCR heteromerization [作者：URIZAR ENEKO; YANO HIDEAKI; KOLSTER RACHEL; GALES CELINE; LAMBERT NEVIN; JAVITCH JONATHAN A,期刊：NATURE CHEMICAL BIOLOGY, 页码：624-630 , 文章类型： Article，,卷期：2011年7-9] Here we present a new method that combines protein complementation with resonance energy transfer to study conformational changes in response to activation of a defined G protein-coupled receptor heteromer, and we apply ... Mechanistic evidence for a front-side, S(N)i-type reaction in a retaining glycosyltransferase [作者：LEE SEUNG SEO; HONG SUNG YOU; ERREY JAMES C; IZUMI ATSUSHI; DAVIES GIDEON J; DAVIS BENJAMIN G,期刊：NATURE CHEMICAL BIOLOGY, 页码：631-638 , 文章类型： Article，,卷期：2011年7-9] A previously determined crystal structure of the ternary complex of trehalose-6-phosphate synthase identified a putative transition state-like arrangement based on validoxylamine A 6'-O-phosphate and uridine diphosphate ... Natural products reveal cancer cell dependence on oxysterol-binding proteins [作者：BURGETT ANTHONY W G; POULSEN THOMAS B; WANGKANONT KITTIKHUN; ANDERSON D RYAN; KIKUCHI CHIKAKO; SHIMADA KOUSEI; OKUBO SHUICHI; FORTNER KEVIN C; MIMAKI YOSHIHIRO; KURODA MINPEI; MURPHY JASON P; SCHWALB DAVID J; PETRELLA EUGENE C; CORNELLATARACIDO IVAN; SCHIRLE MARKUS; TALLARICO JOHN A; SHAIR MATTHEW D,期刊：NATURE CHEMICAL BIOLOGY, 页码：639-647 , 文章类型： Article，,卷期：2011年7-9] Cephalostatin 1, OSW-1, ritterazine B and schweinfurthin A are natural products that potently, and in some cases selectively, inhibit the growth of cultured human cancer cell lines. The cellular targets of these small mo... Behind the folding funnel diagram (vol 7, pg 401, 2011) [作者：KARPLUS MARTIN,期刊：NATURE CHEMICAL BIOLOGY, 页码：648-648 , 文章类型： Correction，,卷期：2011年7-9]