个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共15条记录   Behind the folding funnel diagram [作者：KARPLUS MARTIN,期刊：NATURE CHEMICAL BIOLOGY, 页码：401-404 , 文章类型： Editorial Material，,卷期：2011年7-7] This Commentary clarifies the meaning of the funnel diagram, which has been widely cited in papers on protein folding. To aid in the analysis of the funnel diagram, this Commentary reviews historical approaches to unders... METABOLIC ENGINEERING From retrofitting to green field [作者：NIELSEN LARS K,期刊：NATURE CHEMICAL BIOLOGY, 页码：407-408 , 文章类型： News Item，,卷期：2011年7-7] BIOSYNTHESIS A twist in the tail [作者：WEISSMAN KIRA J,期刊：NATURE CHEMICAL BIOLOGY, 页码：408-411 , 文章类型： News Item，,卷期：2011年7-7] PROTEIN REGULATION The statistical theory of allostery [作者：VENDRUSCOLO MICHELE,期刊：NATURE CHEMICAL BIOLOGY, 页码：411-412 , 文章类型： News Item，,卷期：2011年7-7] HUNTINGTON'S DISEASE Flipping a switch on huntingtin [作者：GREINER ERIN R; YANG X WILLIAM,期刊：NATURE CHEMICAL BIOLOGY, 页码：412-415 , 文章类型： News Item，,卷期：2011年7-7] Antibiotics as probes of biological complexity [作者：FALCONER SHANNON B; CZARNY TOMASZ L; BROWN ERIC D,期刊：NATURE CHEMICAL BIOLOGY, 页码：416-424 , 文章类型： Review，,卷期：2011年7-7] The utility of antibiotics has largely been based on their therapeutic application. However, in addition to clinical use, antibiotics have served as vital agents in probing bacterial complexity. Although not principally ... A universal code for RNA recognition by PUF proteins [作者：FILIPOVSKA ALEKSANDRA; RAZIF MUHAMMAD F M; NYGARD KAROLINE K A; RACKHAM OLIVER,期刊：NATURE CHEMICAL BIOLOGY, 页码：425-427 , 文章类型： Article，,卷期：2011年7-7] The design of proteins that can bind any RNA sequence of interest has many potential biological and medical applications. Here we have expanded the recognition of Pumilio and FBF homology protein (PUF) repeats beyond ade... Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR [作者：REAPER PHILIP M; GRIFFITHS MATTHEW R; LONG JOANNA M; CHARRIER JEANDAMIEN; MACCORMICK SOMHAIRLE; CHARLTON PETER A; GOLEC JULIAN M C; POLLARD JOHN R,期刊：NATURE CHEMICAL BIOLOGY, 页码：428-430 , 文章类型： Article，,卷期：2011年7-7] Here we report a comprehensive biological characterization of a potent and selective small-molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound synthetic lethal interaction between ATR and t... Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase [作者：KOEKSAL MUSTAFA; HU HUAYOU; COATES ROBERT M; PETERS REUBEN J; CHRISTIANSON DAVID W,期刊：NATURE CHEMICAL BIOLOGY, 页码：431-433 , 文章类型： Article，,卷期：2011年7-7] The structure of ent-copalyl diphosphate synthase reveals lthree alpha-helical domains (alpha, beta and gamma), as also observed in the related diterpene cyclase taxadiene synthase. However, active sites are located at t... FrsA functions as a cofactor-independent decarboxylase to control metabolic flux [作者：LEE KYUNGJO; JEONG CHANGSOOK; AN YOUNG JUN; LEE HYUNJUNG; PARK SOONJUNG; SEOK YEONGJAE; KIM PIL; LEE JUNGHYUN; LEE KYUHO; CHA SUNSHIN,期刊：NATURE CHEMICAL BIOLOGY, 页码：434-436 , 文章类型： Article，,卷期：2011年7-7] The interaction between fermentation-respiration switch (FrsA) protein and glucose-specific enzyme IIA(Glc) increases glucose fermentation under oxygen-limited conditions. We show that FrsA converts pyruvate to acetaldeh... A biosensor generated via high-throughput screening quantifies cell edge Src dynamics [作者：GULYANI AKASH; VITRIOL ERIC; ALLEN RICHARD; WU JIANRONG; GREMYACHINSKIY DMITRIY; LEWIS STEVEN; DEWAR BRIAN; GRAVES LEE M; KAY BRIAN K; KUHLMAN BRIAN; ELSTON TIM; HAHN KLAUS M,期刊：NATURE CHEMICAL BIOLOGY, 页码：437-444 , 文章类型： Article，,卷期：2011年7-7] Fluorescent biosensors for living cells currently require laborious optimization and a unique design for each target. They are limited by the availability of naturally occurring ligands with appropriate target specificit... Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol [作者：YIM HARRY; HASELBECK ROBERT; NIU WEI; PUJOLBAXLEY CATHERINE; BURGARD ANTHONY; BOLDT JEFF; KHANDURINA JULIA; TRAWICK JOHN D; OSTERHOUT ROBIN E; STEPHEN ROSARY; ESTADILLA JAZELL; TEISAN SY; SCHREYER H BRETT; ANDRAE STEFAN; YANG TAE HOON; LEE SANG YUP; BURK MARK J; VAN DIEN STEPHEN,期刊：NATURE CHEMICAL BIOLOGY, 页码：445-452 , 文章类型： Article，,卷期：2011年7-7] 1,4-Butanediol (BDO) is an important commodity chemical used to manufacture over 2.5 million tons annually of valuable polymers, and it is currently produced exclusively through feedstocks derived from oil and natural ga... Kinase inhibitors modulate huntingtin cell localization and toxicity [作者：ATWAL RANDY SINGH; DESMOND CARLY R; CARON NICHOLAS; MAIURI TAMARA; XIA JIANRUN; SIPIONE SIMONETTA; TRUANT RAY,期刊：NATURE CHEMICAL BIOLOGY, 页码：453-460 , 文章类型： Article，,卷期：2011年7-7] Two serine residues within the first 17 amino acid residues of huntingtin (N17) are crucial for modulation of mutant huntingtin toxicity in cell and mouse genetic models of Huntington's disease. Here we show that the str... Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation [作者：TAKAHASHI SHUNJI; TOYODA ATSUSHI; SEKIYAMA YASUYO; TAKAGI HIROSHI; NOGAWA TOSHIHIKO; URAMOTO MASAKAZU; SUZUKI RYUICHIRO; KOSHINO HIROYUKI; KUMANO TAKUTO; PANTHEE SURESH; DAIRI TOHRU; ISHIKAWA JUN; IKEDA HARUO; SAKAKI YOSHIYUKI; OSADA HIROYUKI,期刊：NATURE CHEMICAL BIOLOGY, 页码：461-468 , 文章类型： Article，,卷期：2011年7-7] Spiroacetal compounds are ubiquitous in nature, and their stereospecific structures are responsible for diverse pharmaceutical activities. Elucidation of the biosynthetic mechanisms that are involved in spiroacetal forma... Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors [作者：ADIBEKIAN ALEXANDER; MARTIN BRENT R; WANG CHU; HSU KULUNG; BACHOVCHIN DANIEL A; NIESSEN SHERRY; HOOVER HEATHER; CRAVATT BENJAMIN F,期刊：NATURE CHEMICAL BIOLOGY, 页码：469-478 , 文章类型： Article，,卷期：2011年7-7] Serine hydrolases are a diverse enzyme class representing -1% of all human proteins. The biological functions of most serine hydrolases remain poorly characterized owing to a lack of selective inhibitors to probe their a...