个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Women at work [作者：[Anon],期刊：NATURE CHEMICAL BIOLOGY, 页码：245-245 , 文章类型： Editorial Material，,卷期：2011年7-5] PROTEIN AGGREGATION p53 succumbs to peer pressure [作者：MAGZOUB MAZIN; MIRANKER ANDREW D,期刊：NATURE CHEMICAL BIOLOGY, 页码：248-249 , 文章类型： News Item，,卷期：2011年7-5] RECEPTORS Cannabis medicine without a high [作者：CHRISTIE MACDONALD J; VAUGHAN CHRISTOPHER W,期刊：NATURE CHEMICAL BIOLOGY, 页码：249-250 , 文章类型： News Item，,卷期：2011年7-5] SIGNALING Retromer arrests receptor on the run [作者：VAN WEERING JAN R T; CULLEN PETER J,期刊：NATURE CHEMICAL BIOLOGY, 页码：251-252 , 文章类型： News Item，,卷期：2011年7-5] CONTINUOUS EVOLUTION Protein evolution at warp speed [作者：LEHMAN NILES,期刊：NATURE CHEMICAL BIOLOGY, 页码：252-253 , 文章类型： News Item，,卷期：2011年7-5] Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice [作者：CAHALAN STUART M; GONZALEZCABRERA PEDRO J; SARKISYAN GOR; NHAN NGUYEN; SCHAEFFER MARIETHERESE; HUANG LIMING; YEAGER ADAM; CLEMONS BRYAN; SCOTT FIONA; ROSEN HUGH,期刊：NATURE CHEMICAL BIOLOGY, 页码：254-256 , 文章类型： Article，,卷期：2011年7-5] Sphingosine 1-phosphate receptor 1 (S1P(1)) is critical for lymphocyte recirculation and is a clinical target for treatment of multiple sclerosis. By generating a short-duration S1P(1) agonist and mice in which fluoresce... Albumins and their processing machinery are hijacked for cyclic peptides in sunflower [作者：MYLNE JOSHUA S; COLGRAVE MICHELLE L; DALY NORELLE L; CHANSON AURELIE H; ELLIOTT ALYSHA G; MCCALLUM EMILY J; JONES ALUN; CRAIK DAVID J,期刊：NATURE CHEMICAL BIOLOGY, 页码：257-259 , 文章类型： Article，,卷期：2011年7-5] The cyclic peptide sunflower trypsin inhibitor 1 (SFTI-1) blocks trypsin and is a promising drug lead and protein engineering scaffold. We show that SFTI-1 and the newfound SFT-L1 are buried within PawS1 and PawS2, precu... Cholesterol modulates glycolipid conformation and receptor activity [作者：LINGWOOD DANIEL; BINNINGTON BETH; ROG TOMASZ; VATTULAINEN ILPO; GRZYBEK MICHAL; COSKUN UENAL; LINGWOOD CLIFFORD A; SIMONS KAI,期刊：NATURE CHEMICAL BIOLOGY, 页码：260-262 , 文章类型： Article，,卷期：2011年7-5] We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss o... Interfacial enzyme kinetics of a membrane bound kinase analyzed by real-time MAS-NMR [作者：ULLRICH SANDRA J; HELLMICH UTE A; ULLRICH STEFAN; GLAUBITZ CLEMENS,期刊：NATURE CHEMICAL BIOLOGY, 页码：263-270 , 文章类型： Article，,卷期：2011年7-5] The simultaneous observation of interdependent reactions within different phases as catalyzed by membrane-bound enzymes is still a challenging task. One such enzyme, the Escherichia coli integral membrane protein diacylg... Optimization of a blueprint for in vitro glycolysis by metabolic real-time analysis [作者：BUJARA MATTHIAS; SCHUEMPERLI MICHAEL; PELLAUX RENE; HEINEMANN MATTHIAS; PANKE SVEN,期刊：NATURE CHEMICAL BIOLOGY, 页码：271-277 , 文章类型： Article，,卷期：2011年7-5] Recruiting complex metabolic reaction networks for chemical synthesis has attracted considerable attention but frequently requires optimization of network composition and dynamics to reach sufficient productivity. As a d... Retromer terminates the generation of cAMP by internalized PTH receptors [作者：FEINSTEIN TIMOTHY N; WEHBI VANESSA L; ARDURA JUAN A; WHEELER DAVID S; FERRANDON SEBASTIEN; GARDELLA THOMAS J; VILARDAGA JEANPIERRE,期刊：NATURE CHEMICAL BIOLOGY, 页码：278-284 , 文章类型： Article，,卷期：2011年7-5] The generation of cAMP by G protein-coupled receptors (GPCRs) and its termination are currently thought to occur exclusively at the plasma membrane of cells. Under existing models of receptor regulation, this signal is p... Gain of function of mutant p53 by coaggregation with multiple tumor suppressors [作者：XU JIE; REUMERS JOKE; COUCEIRO JOSE R; DE SMET FREDERIK; GALLARDO RODRIGO; RUDYAK STANISLAV; CORNELIS ANN; ROZENSKI JEF; ZWOLINSKA ALEKSANDRA; MARINE JEANCHRISTOPHE; LAMBRECHTS DIETHER; SUH YOUNGAH; ROUSSEAU FREDERIC; SCHYMKOWITZ JOOST,期刊：NATURE CHEMICAL BIOLOGY, 页码：285-295 , 文章类型： Article，,卷期：2011年7-5] Many p53 missense mutations possess dominant-negative activity and oncogenic gain of function. We report that for structurally destabilized p53 mutants, these effects result from mutant-induced coaggregation of wild-type... Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia [作者：XIONG WEI; CHENG KEJUN; CUI TANXING; GODLEWSKI GRZEGORZ; RICE KENNER C; XU YAN; ZHANG LI,期刊：NATURE CHEMICAL BIOLOGY, 页码：296-303 , 文章类型： Article，,卷期：2011年7-5] Cannabinoids enhance the function of glycine receptors (GlyRs). However, little is known about the mechanisms and behavioral implication of cannabinoid-GlyR interaction. Using mutagenesis and NMR analysis, we have identi... Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds [作者：LIU YUCHEN; LI YISHAN; LYU SYUEYI; HSU LIJEN; CHEN YUHOU; HUANG YUTING; CHAN HSIUCHIEN; HUANG CHUENJIUAN; CHEN GANHONG; CHOU CHIACHENG; TSAI MINGDAW; LI TSUNGLIN,期刊：NATURE CHEMICAL BIOLOGY, 页码：304-309 , 文章类型： Article，,卷期：2011年7-5] In the search for new efficacious antibiotics, biosynthetic engineering offers attractive opportunities to introduce minor alterations to antibiotic structures that may overcome resistance. Dbv29, a flavin-containing oxi... A unique iron-sulfur cluster is crucial for oxygen tolerance of a [NiFe]-hydrogenase [作者：GORIS TOBIAS; WAIT ANNEMARIE F; SAGGU MIGUEL; FRITSCH JOHANNES; HEIDARY NINA; STEIN MATTHIAS; ZEBGER INGO; LENDZIAN FRIEDHELM; ARMSTRONG FRASER A; FRIEDRICH BAERBEL; LENZ OLIVER,期刊：NATURE CHEMICAL BIOLOGY, 页码：310-U87 , 文章类型： Article，,卷期：2011年7-5] Hydrogenases are essential for H-2 cycling in microbial metabolism and serve as valuable blueprints for H-2-based biotechnological applications. However, most hydrogenases are extremely oxygen sensitive and prone to inac... Dynamics connect substrate recognition to catalysis in protein kinase A (vol 6, pg 821, 2010) [作者：MASTERSON LARRY R; CHENG CECILIA; YU TAO; TONELLI MARCO; KORNEV ALEXANDR; TAYLOR SUSAN S; VEGLIA GIANLUIGI,期刊：NATURE CHEMICAL BIOLOGY, 页码：319-319 , 文章类型： Correction，,卷期：2011年7-5]