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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   BIOMATERIALS Metabolites empowering minerals [作者：WEISS INGRID M,期刊：NATURE CHEMICAL BIOLOGY, 页码：192-193 , 文章类型： News Item，,卷期：2011年7-4] PROTEIN DYNAMICS Bridging the gap [作者：DAUGHDRILL GARY W,期刊：NATURE CHEMICAL BIOLOGY, 页码：193-194 , 文章类型： News Item，,卷期：2011年7-4] SCREENING Low-fat worms on drugs [作者：WAGNER BRIDGET K,期刊：NATURE CHEMICAL BIOLOGY, 页码：194-195 , 文章类型： News Item，,卷期：2011年7-4] BIOFUELS Chimeric synthetic pathways [作者：NIELSEN JENS,期刊：NATURE CHEMICAL BIOLOGY, 页码：195-196 , 文章类型： News Item，,卷期：2011年7-4] Glycolytic intermediates induce amorphous calcium carbonate formation in crustaceans [作者：SATO AI; NAGASAKA SEIJI; FURIHATA KAZUO; NAGATA SHINJI; ARAI ISAO; SARUWATARI KAZUKO; KOGURE TOSHIHIRO; SAKUDA SHOHEI; NAGASAWA HIROMICHI,期刊：NATURE CHEMICAL BIOLOGY, 页码：197-199 , 文章类型： Article，,卷期：2011年7-4] It has been thought that phosphorus in biominerals made of amorphous calcium carbonate (ACC) might be related to ACC formation, but no such phosphorus-containing compounds have ever been identified. Crustaceans use ACC b... Navigating the kinome [作者：METZ JAMES T; JOHNSON ERIC F; SONI NIRU B; MERTA PHILIP J; KIFLE LEMMA; HAJDUK PHILIP J,期刊：NATURE CHEMICAL BIOLOGY, 页码：200-202 , 文章类型： Article，,卷期：2011年7-4] Although it is increasingly being recognized that drug-target interaction networks can be powerful tools for the interrogation of systems biology and the rational design of multitargeted drugs, there is no generalized, s... Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2 [作者：DENG XIANMING; DZAMKO NICOLAS; PRESCOTT ALAN; DAVIES PAUL; LIU QINGSONG; YANG QINGKAI; LEE JIINGDWAN; PATRICELLI MATTHEW P; NOMANBHOY TYZOON K; ALESSI DARIO R; GRAY NATHANAEL S,期刊：NATURE CHEMICAL BIOLOGY, 页码：203-205 , 文章类型： Article，,卷期：2011年7-4] Mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with late-onset autosomal dominant Parkinson's disease. We employed a new, parallel, compound-centric approach to identify a potent and selective ... A whole-organism screen identifies new regulators of fat storage [作者：LEMIEUX GEORGE A; LIU JASON; MAYER NASIMA; BAINTON ROLAND J; ASHRAFI KAVEH; WERB ZENA,期刊：NATURE CHEMICAL BIOLOGY, 页码：206-213 , 文章类型： Article，,卷期：2011年7-4] The regulation of energy homeostasis integrates diverse biological processes ranging from behavior to metabolism and is linked fundamentally to numerous disease states. To identify new molecules that can bypass homeostat... Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21 [作者：WANG YUEFENG; FISHER JOHN C; MATHEW ROSE; OU LI; OTIENO STEVE; SUBLET JACK; XIAO LIMIN; CHEN JIANHAN; ROUSSEL MARTINE F; KRIWACKI RICHARD W,期刊：NATURE CHEMICAL BIOLOGY, 页码：214-221 , 文章类型： Article，,卷期：2011年7-4] Traditionally, well-defined three-dimensional structure has been thought to be essential for protein function. However, myriad biological functions are performed by highly dynamic, intrinsically disordered proteins (IDPs... Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways [作者：BONDWATTS BROOKS B; BELLEROSE ROBERT J; CHANG MICHELLE C Y,期刊：NATURE CHEMICAL BIOLOGY, 页码：222-227 , 文章类型： Article，,卷期：2011年7-4] Living systems have evolved remarkable molecular functions that can be redesigned for in vivo chemical synthesis as we gain a deeper understanding of the underlying biochemical principles for de novo construction of synt... Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis [作者：BACKUS KERIANN M; BOSHOFF HELENA L; BARRY CONOR S; BOUTUREIRA OMAR; PATEL MITUL K; DHOOGE FRANCOIS; LEE SEUNG SEO; VIA LAURA E; TAHLAN KAPIL; BARRY CLIFTON E III; DAVIS BENJAMIN G,期刊：NATURE CHEMICAL BIOLOGY, 页码：228-235 , 文章类型： Article，,卷期：2011年7-4] The detection of tuberculosis currently relies upon insensitive and unspecific techniques; newer diagnostics would ideally co-opt specific bacterial processes to provide real-time readouts. The trehalose mycolyltranseste... Structural basis for RNA trimming by RNase T in stable RNA 3 '-end maturation [作者：HSIAO YUYUAN; YANG CHECHUAN; LIN CHIA LIANG; LIN JASON L J; DUH YULANDER; YUAN HANNA S,期刊：NATURE CHEMICAL BIOLOGY, 页码：236-243 , 文章类型： Article，,卷期：2011年7-4] RNA maturation relies on various exonucleases to remove nucleotides successively from the 5' or 3' end of nucleic acids. However, little is known regarding the molecular basis for substrate and cleavage preference of exo...