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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共30条记录   Umbilicus as a fitness signal in humans [作者：Sinkkonen, A,期刊：FASEB Journal, 页码：10-12 , 文章类型： Article，,卷期：2009年23-1] Typically, mammalian umbilical cord forms a tiny, stable, and asymmetrical scar. In contrast, humans have a clearly visible umbilicus that changes with age and nutrients gathered. Based on this, I propose that umbilicus,... A fossil antibacterial peptide gives clues to structural diversity of cathelicidin-derived host defense peptides [作者：Zhu, SY; Gao, B,期刊：FASEB Journal, 页码：13-20 , 文章类型： Article，,卷期：2009年23-1] Cathelicidins, a group of vertebrate-specific immune effector molecules, developed into a multigene family through gene duplication in the Cetartiodactyla lineage, in which structural changes of the antimicrobial domains... Characterization of sonic hedgehog as a novel NF-kappa B target gene that promotes NF-kappa B-mediated apoptosis resistance and tumor growth in vivo [作者：Kasperczyk, H; Baumann, B; Debatin, KM; Fulda, S,期刊：FASEB Journal, 页码：21-33 , 文章类型： Article，,卷期：2009年23-1] To explore mechanisms controlling sonic hedgehog (Shh) expression in human cancers, we investigated regulation of Shh by the transcription factor NF-kappa B. We identify putative NF-kappa B binding sites in the human Shh... Oxidative, multistep activation of the noncanonical NF-kappa B pathway via disulfide Bcl-3/p50 complex [作者：Cristofanon, S; Morceau, F; Scovassi, AI; Dicato, M; Ghibelli, L; Diederich, M,期刊：FASEB Journal, 页码：45-57 , 文章类型： Article，,卷期：2009年23-1] Buthionine sulfoximine ( BSO) is a well-known inhibitor of glutathione synthesis, producing slow glutathione ( GSH) depletion and oxidative stress; some "responder" cells avoid BSO-induced death by trans-activating the p... Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol [作者：Vikman, J; Jimenez-Feltstrom, J; Nyman, P; Thelin, J; Eliasson, L,期刊：FASEB Journal, 页码：58-67 , 文章类型： Article，,卷期：2009年23-1] Cholesterol-rich clusters of SNARE (soluble NSF attachment protein receptor) proteins have been implicated as being important for exocytosis. Here we demonstrate the significance of cholesterol for normal biphasic insuli... Microenvironment drives the endothelial or neural fate of differentiating embryonic stem cells coexpressing neuropilin-1 and Flk-1 [作者：Gualandris, A; Noghero, A; Geuna, M; Arese, M; Valdembri, D; Serini, G; Bussolino, F,期刊：FASEB Journal, 页码：68-78 , 文章类型： Article，,卷期：2009年23-1] The observation that the architecture of the cardiovascular and nervous systems is drawn by common guidance cues and the closeness between neural progenitors and endothelial cells in the vascular niche strongly suggests ... F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation [作者：Attur, MG; Palmer, GD; Al-Mussawir, HE; Dave, M; Teixeira, CC; Rifkin, DB; Appleton, CTG; Beier, F; Abramson, SB,期刊：FASEB Journal, 页码：79-89 , 文章类型： Article，,卷期：2009年23-1] In osteoarthritis (OA) articular chondrocytes undergo phenotypic changes culminating in the progressive loss of cartilage from the joint surface. The molecular mechanisms underlying these changes are poorly understood. H... Discovery in the lab: Plato's paradox and Delbruck's principle of limited sloppiness [作者：Grinnell, F,期刊：FASEB Journal, 页码：7-9 , 文章类型： Article，,卷期：2009年23-1] Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase [作者：Canugovi, C; Samaranayake, M; Bhagwat, AS,期刊：FASEB Journal, 页码：34-44 , 文章类型： Article，,卷期：2009年23-1] Transcription of the rearranged immunoglobulin gene and expression of the enzyme activation-induced deaminase (AID) are essential for somatic hypermutations of this gene during antibody maturation. While AID acts as a si... Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia [作者：Saslowsky, DE; Tanaka, N; Reddy, KP; Lencer, WI,期刊：FASEB Journal, 页码：259-270 , 文章类型： Article，,卷期：2009年23-1] Sphingomyelinases (SMases) hydrolyze membrane sphingomyelin to ceramide and are expressed by diverse host and microbial cell types populating mucosal surfaces. Exogenous bacterial SMase acts on the basolateral membrane o... High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice [作者：Jones, HN; Woollett, LA; Barbour, N; Prasad, PD; Powell, TL; Jansson, T,期刊：FASEB Journal, 页码：271-278 , 文章类型： Article，,卷期：2009年23-1] Maternal overweight and obesity in pregnancy often result in fetal overgrowth, which increases the risk for the baby to develop metabolic syndrome later in life. However, the mechanisms underlying fetal overgrowth are no... Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stability [作者：Zhang, JH; Cao, RH; Zhang, Y; Jia, TH; Cao, YH; Wahlberg, E,期刊：FASEB Journal, 页码：153-163 , 文章类型： Article，,卷期：2009年23-1] Preclinical and clinical evaluations of individual proangiogenic/arteriogenic factors for the treatment of ischemic myocardium and skeletal muscle have produced unfulfilled promises. The establishment of functional and s... Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1 [作者：Tan, LD; Sarkis, PTN; Wang, T; Tian, CJ; Yu, XF,期刊：FASEB Journal, 页码：279-287 , 文章类型： Article，,卷期：2009年23-1] Human cytidine deaminase apolipoprotein B mRNA-editing catalytic polypeptide-like 3 (APOBEC3) proteins have been classified as either Z1- or Z2-type cytidine deaminases on the basis of phylogenetic analysis of their cata... Functional analysis of monocyte MHC class II compartments [作者：Bunbury, A; Potolicchio, I; Maitra, R; Santambrogio, L,期刊：FASEB Journal, 页码：164-171 , 文章类型： Article，,卷期：2009年23-1] Circulating monocytes, as dendritic cell and macrophage precursors, exhibit several functions usually associated with antigen-presenting cells, such as phagocytosis and presence of endosomal/lysosomal degradative compart... A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum [作者：Errasti-Murugarren, E; Molina-Arcas, M; Casado, FJ; Pastor-Anglada, M,期刊：FASEB Journal, 页码：172-182 , 文章类型： Article，,卷期：2009年23-1] Nucleoside transporters are plasma membrane proteins essential for nucleoside salvage. Among them, human concentrative nucleoside transporter 3 (hCNT3, SLC28A3) plays an essential role in this process because of its broa... The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation [作者：Henstridge, CM; Balenga, NAB; Ford, LA; Ross, RA; Waldhoer, M; Irving, AJ,期刊：FASEB Journal, 页码：183-193 , 文章类型： Article，,卷期：2009年23-1] The endogenous phospholipid L-alpha-lysophosphatidylinositol (LPI) was recently identified as a novel ligand for the orphan G protein-coupled receptor 55 (GPR55). In this study we define the downstream signaling pathways...