个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共36条记录   Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity [作者：Antony, J; Kellershohn, K; Mohr-Andra, M; Kebig, A; Prilla, S; Muth, M; Heller, E; Disingrini, T; Dallanoce, C; Bertoni, S; Schrobang, J; Trankle, C; Kostenis, E; Christopoulos, A; Holtje, HD; Barocelli, E; De Amici, M; Holzgrabe, U; Mohr, K,期刊：FASEB Journal, 页码：442-450 , 文章类型： Article，,卷期：2009年23-2] Selective modulation of cell function by G protein-coupled receptor (GPCR) activation is highly desirable for basic research and therapy but difficult to achieve. We present a novel strategy toward this goal using muscar... Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery [作者：Wang, Y; Meriin, AB; Zaarur, N; Romanova, NV; Chernoff, YO; Costello, CE; Sherman, MY,期刊：FASEB Journal, 页码：451-463 , 文章类型： Article，,卷期：2009年23-2] In mammalian cells, abnormal proteins that escape proteasome-dependent degradation form small aggregates that can be transported into a centrosome-associated structure, called an aggresome. Here we demonstrate that in ye... Methionine in proteins defends against oxidative stress [作者：Luo, S; Levine, RL,期刊：FASEB Journal, 页码：464-472 , 文章类型： Article，,卷期：2009年23-2] A variety of reactive oxygen species react readily with methionine residues in proteins to form methionine sulfoxide, thus scavenging the reactive species. Most cells contain methionine sulfoxide reductases, which cataly... Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs [作者：Reutershan, J; Vollmer, I; Stark, S; Wagner, R; Ngamsri, KC; Eltzschig, HK,期刊：FASEB Journal, 页码：473-482 , 文章类型： Article，,卷期：2009年23-2] Extracellular adenosine has been implicated as anti-inflammatory signaling molecule during acute lung injury (ALI). The main source of extracellular adenosine stems from a coordinated two-step enzymatic conversion of pre... Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice [作者：Lippuner, C; Paape, D; Paterou, A; Brand, J; Richardson, M; Smith, AJ; Hoffmann, K; Brinkmann, V; Blackburn, C; Aebischer, T,期刊：FASEB Journal, 页码：483-491 , 文章类型： Article，,卷期：2009年23-2] The small GTPase Rab5 is a key regulator of endosome/phagosome maturation and in intravesicular infections marks a phagosome stage at which decisions over pathogen replication or destruction are integrated. It is current... Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium [作者：Porter, JC; Hall, A,期刊：FASEB Journal, 页码：492-502 , 文章类型： Article，,卷期：2009年23-2] Egression of inflammatory cells from the lung interstitium into the airway lumen is critical for the resolution of inflammation, but the underlying mechanisms of this egression are unclear. Here, we use an in vitro syste... Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation [作者：Yang, BX; Zhao, D; Verkman, AS,期刊：FASEB Journal, 页码：503-512 , 文章类型： Article，,卷期：2009年23-2] Mutations in aquaporin-2 (AQP2) that interfere with its cellular processing can produce autosomal recessive nephrogenic diabetes insipidus (NDI). Prior gene knock-in of the human NDI-causing AQP2 mutation T126M produced ... Caveolin-1 regulates the secretion and cytoprotection of Cyr61 in hyperoxic cell death [作者：Jin, Y; Kim, HP; Cao, JF; Zhang, M; Ifedigbo, E; Choi, AMK,期刊：FASEB Journal, 页码：341-350 , 文章类型： Article，,卷期：2009年23-2] Cysteine-rich 61 (Cyr61) belongs to the CCN family and mediates cell proliferation, survival, and apoptosis. Our previous studies showed that Cyr61 protected against hyperoxia-induced lung cell death via Akt phosphorylat... Erythropoietin administration after myocardial infarction in mice attenuates ischemic cardiomyopathy associated with enhanced homing of bone marrow-derived progenitor cells via the CXCR-4/SDF-1 axis [作者：Brunner, S; Winogradow, J; Huber, BC; Zaruba, MM; Fischer, R; David, R; Assmann, G; Herbach, N; Wanke, R; Mueller-Hoecker, J; Franz, WM,期刊：FASEB Journal, 页码：351-361 , 文章类型： Article，,卷期：2009年23-2] Mobilization of bone marrow-derived stem cells (BMCs) was shown to have protective effects after myocardial infarction (MI). However, the classical mobilizing agent, granulocyte-colony stimulating factor (G-CSF) relapsed... The I kappa B kinases IKK alpha and IKK beta are necessary and sufficient for skeletal muscle atrophy [作者：Van Gammeren, D; Damrauer, JS; Jackman, RW; Kandarian, SC,期刊：FASEB Journal, 页码：362-370 , 文章类型： Article，,卷期：2009年23-2] Nuclear factor-kappa B (NF-kappa B) signaling is necessary for many types of muscle atrophy, yet only some of the required components have been identified. Gene transfer of a dominant negative (d.n.) IKK beta into rat so... Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin [作者：Jastrzebska, B; Golczak, M; Fotiadis, D; Engel, A; Palczewski, K,期刊：FASEB Journal, 页码：371-381 , 文章类型： Article，,卷期：2009年23-2] Transitory binding between photoactivated rhodopsin (Rho* or Meta II) and the G protein transducin (Gt-GDP) is the first step in the visual signaling cascade. Light causes photoisomerization of the 11-cis-retinylidene ch... Bone marrow-derived cell regulation of skeletal muscle regeneration [作者：Sun, DX; Martinez, CO; Ochoa, O; Ruiz-Willhite, L; Bonilla, JR; Centonze, VE; Waite, LL; Michalek, JE; McManus, LM; Shireman, PK,期刊：FASEB Journal, 页码：382-395 , 文章类型： Article，,卷期：2009年23-2] Limb regeneration requires the coordination of multiple stem cell populations to recapitulate the process of tissue formation. Therefore, bone marrow (BM) -derived cell regulation of skeletal muscle regeneration was exam... Structural insight into acute intermittent porphyria [作者：Song, GJ; Li, Y; Cheng, CY; Zhao, Y; Gao, A; Zhang, RG; Joachimiak, A; Shaw, N; Liu, ZJ,期刊：FASEB Journal, 页码：396-404 , 文章类型： Article，,卷期：2009年23-2] Acute intermittent porphyria (AIP), an inherited disease of heme biosynthesis, is one of the most common types of porphyria. Reduced activity of the enzyme porphobilinogen deaminase (PBGD), which catalyzes the sequential... Role for sphingosine kinase 1 in colon carcinogenesis [作者：Kawamori, T; Kaneshiro, T; Okumura, M; Maalouf, S; Uflacker, A; Bielawski, J; Hannun, YA; Obeid, LM,期刊：FASEB Journal, 页码：405-414 , 文章类型： Article，,卷期：2009年23-2] Sphingosine kinase 1 (SphK1) phosphorylates sphingosine to form sphingosine-1-phosphate (S1P) and is a critical regulator of sphingolipid-mediated functions. Cell-based studies suggest a tumor-promoting function for the ... Recognition of galactan components of pectin by galectin-3 [作者：Gunning, AP; Bongaerts, RJM; Morris, VJ,期刊：FASEB Journal, 页码：415-424 , 文章类型： Article，,卷期：2009年23-2] It has been reported that modified forms of pectin possess anticancer activity. To account for this bioactivity, it has been proposed that fragments of pectin molecules can act by binding to and inhibiting the various ro... Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells [作者：Zou, HF; Thomas, SM; Yan, ZW; Grandis, JR; Vogt, A; Li, LY,期刊：FASEB Journal, 页码：425-432 , 文章类型： Article，,卷期：2009年23-2] Epidermal growth factor receptor (EGFR) is an activated oncogene in many cancers. It can be transactivated by ligands of G protein-coupled receptors (GPCRs). We show here that a novel gene, human rhomboid family-1 (RHBDF...