个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共6条记录   Circadian dysfunction in disease [作者：Bechtold, DA; Gibbs, JE; Loudon, ASI,期刊：Trends in Pharmacological Sciences, 页码：191-198 , 文章类型： Review，,卷期：2010年31-5] The classic view of circadian timing in mammals emphasizes a light-responsive 'master clock' within the hypothalamus which imparts temporal information to the organism. Recent work indicates that such a unicentric model ... Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases [作者：Godin, B; Sakamoto, JH; Serda, RE; Grattoni, A; Bouamrani, A; Ferrari, M,期刊：Trends in Pharmacological Sciences, 页码：199-205 , 文章类型： Review，,卷期：2010年31-5] Nanomedicine is an emerging field that utilizes nano-technology concepts for advanced therapy and diagnostics. This convergent discipline merges research areas such as chemistry, biology, physics, mathematics and enginee... Therapy for persistent HIV [作者：Keedy, KS; Margolis, DM,期刊：Trends in Pharmacological Sciences, 页码：206-211 , 文章类型： Review，,卷期：2010年31-5] Given the scope of the human immunodeficiency virus (HIV) pandemic, millions of people will need of chronic antiretroviral therapy (ART) for decades into the future. It is hoped that progress in prevention of HIV infecti... Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases [作者：Imai, S; Guarente, L,期刊：Trends in Pharmacological Sciences, 页码：212-220 , 文章类型： Review，,卷期：2010年31-5] Since the discovery of NAD-dependent deacetylase activity of the silent information regulator-2 (SIR2) family ('sirtuins'), many exciting connections between protein deacetylation and energy metabolism have been revealed... Signaling by internalized G-protein-coupled receptors [作者：Calebiro, D; Nikolaev, VO; Persani, L; Lohse, MJ,期刊：Trends in Pharmacological Sciences, 页码：221-228 , 文章类型： Review，,卷期：2010年31-5] G-protein-coupled receptors (GPCRs) are cell surface receptors and are generally assumed to signal to second messengers such as cyclic AMP (cAMP) exclusively from the plasma membrane. However, recent studies indicate tha... New structure enlivens interest in P2X receptors [作者：Browne, LE; Jiang, LH; North, RA,期刊：Trends in Pharmacological Sciences, 页码：229-237 , 文章类型： Review，,卷期：2010年31-5] P2X receptors are ATP-gated membrane ion channels with multifarious roles, including afferent sensation, autocrine feedback loops, and inflammation. Their molecular operation has been less well elucidated compared with o...