- Homozygous Mutations in NEUROD1 Are Responsible for a Novel Syndrome of Permanent Neonatal Diabetes and Neurological Abnormalities
[作者：Rubio-Cabezas, O; Minton, JAL; Kantor, I; Williams, D; Ellard, S; Hattersley, AT,期刊：Diabetes, 页码：2326-2331 , 文章类型： Article，,卷期：2010年59-9]
- OBJECTIVE-NEUROD1 is expressed in both developing and mature beta-cells. Studies in mice suggest that this basic helix-loop-helix transcription factor is critical in the development of endocrine cell lineage. Heterozygou...
- Improvement of Retinal Vascular Injury in Diabetic Rats by Statins Is Associated With the Inhibition of Mitochondrial Reactive Oxygen Species Pathway Mediated by Peroxisome Proliferator-Activated Receptor gamma Coactivator 1 alpha
[作者：Zheng, Z; Chen, HB; Wang, H; Ke, BL; Zheng, BQ; Li, QA; Li, PY; Su, L; Gu, Q; Xu, X,期刊：Diabetes, 页码：2315-2325 , 文章类型： Article，,卷期：2010年59-9]
- OBJECTIVE-Mitochondrial reactive oxygen species (ROS) plays a key role in diabetic retinopathy (DR) pathogenesis. However, whether simvastatin decreases diabetes-induced mitochondrial ROS production remains uncertain. Th...
- Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance
[作者：Hoeks, J; van Herpen, NA; Mensink, M; Moonen-Kornips, E; van Beurden, D; Hesselink, MKC; Schrauwen, P,期刊：Diabetes, 页码：2117-2125 , 文章类型： Article，,卷期：2010年59-9]
- OBJECTIVE-Type 2 diabetes and insulin resistance have been associated with mitochondrial dysfunction, but it is debated whether this is a primary factor in the pathogenesis of the disease. To test the concept that mitoch...
- Ablation of 4E-BP1/2 Prevents Hyperglycemia-Mediated Induction of VEGF Expression in the Rodent Retina and in Muller Cells in Culture
[作者：Schrufer, TL; Antonetti, DA; Sonenberg, N; Kimball, SR; Gardner, TW; Jefferson, LS,期刊：Diabetes, 页码：2107-2116 , 文章类型： Article，,卷期：2010年59-9]
- OBJECTIVE-Vascular endothelial growth factor (VEGF) contributes to diabetic retinopathy, but control of its expression is not well understood. Here, we tested the hypothesis that hyperglycemia mediates induction of VEGF ...
- Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men
[作者：Buxton, OM; Pavlova, M; Reid, EW; Wang, W; Simonson, DC; Adler, GK,期刊：Diabetes, 页码：2126-2133 , 文章类型： Article，,卷期：2010年59-9]
- OBJECTIVE-Short sleep duration is associated with impaired glucose tolerance and an increased risk of diabetes. The effects of sleep restriction on insulin sensitivity have not been established. This study tests the hypo...
- Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans
[作者：Tong, J; Prigeon, RL; Davis, HW; Bidlingmaier, M; Kahn, SE; Cummings, DE; Tschop, MH; D'Alessio, D,期刊：Diabetes, 页码：2145-2151 , 文章类型： Article，,卷期：2010年59-9]
- OBJECTIVE-The orexigenic gut hormone ghrelin and its receptor are present in pancreatic islets. Although ghrelin reduces insulin secretion in rodents, its effect on insulin secretion in humans has not been established. T...
- Glucose-Dependent Insulinotropic Polypeptide May Enhance Fatty Acid Re-esterification in Subcutaneous Abdominal Adipose Tissue in Lean Humans
[作者：Asmar, M; Simonsen, L; Madsbad, S; Stallknecht, B; Holst, JJ; Bulow, J,期刊：Diabetes, 页码：2160-2163 , 文章类型： Article，,卷期：2010年59-9]
- OBJECTIVE-Glucose-dependent insulinotropic polypeptide (GIP) has been implicated in lipid metabolism in animals. In humans, however, there is no clear evidence of GIP effecting lipid metabolism. The present experiments w...
- Nitric Oxide Synthesis Is Reduced in Subjects With Type 2 Diabetes and Nephropathy
[作者：Tessari, P; Cecchet, D; Cosma, A; Vettore, M; Coracina, A; Millioni, R; Iori, E; Puricelli, L; Avogaro, A; Vedovato, M,期刊：Diabetes, 页码：2152-2159 , 文章类型： Article，,卷期：2010年59-9]
- OBJECTIVE-Nitric oxide (NO) is a key metabolic and vascular regulator. Its production is stimulated by insulin. A reduced urinary excretion of NO products (NOx) is frequently found in type 2 diabetes, particularly in ass...
- Increased Brain Fatty Acid Uptake in Metabolic Syndrome
[作者：Karmi, A; Iozzo, P; Viljanen, A; Hirvonen, J; Fielding, BA; Virtanen, K; Oikonen, V; Kemppainen, J; Viljanen, T; Guiducci, L; Haaparanta-Solin, M; Nagren, K; Solin, O; Nuutila, P,期刊：Diabetes, 页码：2171-2177 , 文章类型： Article，,卷期：2010年59-9]
- OBJECTIVE-To test whether brain fatty acid uptake is enhanced in obese subjects with metabolic syndrome (MS) and whether weight reduction modifies it. RESEARCH DESIGN AND METHODS-We measured brain fatty acid uptake in a ...
- Short-Term Overfeeding May Induce Peripheral Insulin Resistance Without Altering Subcutaneous Adipose Tissue Macrophages in Humans
[作者：Tam, CS; Viardot, A; Clement, K; Tordjman, J; Tonks, K; Greenfield, JR; Campbell, LV; Samocha-Bonet, D; Heilbronn, LK,期刊：Diabetes, 页码：2164-2170 , 文章类型： Article，,卷期：2010年59-9]
- OBJECTIVE-Chronic low-grade inflammation is a feature of obesity and is postulated to be causal in the development of insulin resistance and type 2 diabetes. The aim of this study was to assess whether overfeeding induce...
- beta-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced beta-Cell Mass
[作者：Peyot, ML; Pepin, E; Lamontagne, J; Latour, MG; Zarrouki, B; Lussier, R; Pineda, M; Jetton, TL; Madiraju, SRM; Joly, E; Prentki, M,期刊：Diabetes, 页码：2178-2187 , 文章类型： Article，,卷期：2010年59-9]
- OBJECTIVE-C57Bl/6 mice develop obesity and mild hyperglycemia when fed a high-fat diet (HFD). Although diet-induced obesity (DIO) is a widely studied model of type 2 diabetes, little is known about beta-cell failure in t...
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