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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共37条记录   Pathogenesis of Fasting and Postprandial Hyperglycemia in Type 2 Diabetes: Implications for Therapy [作者：Rizza, RA,期刊：Diabetes, 页码：2697-2707 , 文章类型： Proceedings Paper，,卷期：2010年59-11] The objective of this research is to gain a greater understanding of the cause of fasting and postprandial hyperglycemia in people with type 2 diabetes. Endogenous glucose production is excessive before eating and fails ... Neutralization of Interleukin-16 Protects Nonobese Diabetic Mice From Autoimmune Type 1 Diabetes by a CCL4-Dependent Mechanism [作者：Meagher, C; Beilke, J; Arreaza, G; Mi, QS; Chen, W; Salojin, K; Horst, N; Cruikshank, WW; Delovitch, TL,期刊：Diabetes, 页码：2862-2871 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-The progressive infiltration of pancreatic islets by lymphocytes is mandatory for development of autoimmune type 1 diabetes. This inflammatory process is mediated by several mediators that are potential ther... Nuclear Hormone Retinoid X Receptor (RXR) Negatively Regulates the Glucose-Stimulated Insulin Secretion of Pancreatic beta-Cells [作者：Miyazaki, S; Taniguchi, H; Moritoh, Y; Tashiro, F; Yamamoto, T; Yamato, E; Ikegami, H; Ozato, K; Miyazaki, J,期刊：Diabetes, 页码：2854-2861 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-Retinoid X receptors (RXRs) are members of the nuclear hormone receptor superfamily and are thought to be key regulators in differentiation, cellular growth, and gene expression. Although several experiments us... Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence [作者：Villaret, A; Galitzky, J; Decaunes, P; Esteve, D; Marques, MA; Sengenes, C; Chiotasso, P; Tchkonia, T; Lafontan, M; Kirkland, JL; Bouloumie, A,期刊：Diabetes, 页码：2755-2763 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-Regional differences among adipose depots in capacities for fatty acid storage, susceptibility to hypoxia, and inflammation likely contribute to complications of obesity. We defined the properties of endothelia... Liver Fat Content in Type 2 Diabetes: Relationship With Hepatic Perfusion and Substrate Metabolism [作者：Rijzewijk, LJ; van der Meer, RW; Lubberink, M; Lamb, HJ; Romijn, JA; de Roos, A; Twisk, JW; Heine, RJ; Lammertsma, AA; Smit, JWA; Diamant, M,期刊：Diabetes, 页码：2747-2754 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-Hepatic steatosis is common in type 2 diabetes. It is causally linked to the features of the metabolic syndrome, liver cirrhosis, and cardiovascular disease. Experimental data have indicated that increased live... Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State [作者：Fisher, FM; Chui, PC; Antonellis, PJ; Bina, HA; Kharitonenkov, A; Flier, JS; Maratos-Flier, E,期刊：Diabetes, 页码：2781-2789 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-Fibroblast growth factor 21 (FGF21) is a key mediator of fatty acid oxidation and lipid metabolism. Pharmacological doses of FGF21 improve glucose tolerance, lower serum free fatty acids, and lead to weight los... DsbA-L Alleviates Endoplasmic Reticulum Stress-Induced Adiponectin Downregulation [作者：Zhou, LJ; Liu, ML; Zhang, JJ; Chen, HZ; Dong, LQ; Liu, F,期刊：Diabetes, 页码：2809-2816 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-Obesity impairs adiponectin expression, assembly, and secretion, yet the underlying mechanisms remain elusive. The aims of this study were 1) to determine the molecular mechanisms by which obesity impairs adipo... Expression of Human Chemerin Induces Insulin Resistance in the Skeletal Muscle but Does Not Affect Weight, Lipid Levels, and Atherosclerosis in LDL Receptor Knockout Mice on High-Fat Diet [作者：Becker, M; Rabe, K; Lebherz, C; Zugwurst, J; Goke, B; Parhofer, KG; Lehrke, M; Broedl, UC,期刊：Diabetes, 页码：2898-2903 , 文章类型： Article，,卷期：2010年59-11] INS-1 Cells Undergoing Caspase-Dependent Apoptosis Enhance the Regenerative Capacity of Neighboring Cells [作者：Bonner, C; Bacon, S; Concannon, CG; Rizvi, SR; Baquie, M; Farrelly, AM; Kilbride, SM; Dussmann, H; Ward, MW; Boulanger, CM; Wollheim, CB; Graf, R; Byrne, MM; Prehn, JHM,期刊：Diabetes, 页码：2799-2808 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-In diabetes, beta-cell mass is not static but in a constant process of cell death and renewal. Inactivating mutations in transcription factor 1 (tcf-1)/hepatocyte nuclear factor1a (hnf1a) result in decreased be... Residual Insulin Production and Pancreatic beta-Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study [作者：Keenan, HA; Sun, JK; Levine, J; Doria, A; Aiello, LP; Eisenbarth, G; Bonner-Weir, S; King, GL,期刊：Diabetes, 页码：2846-2853 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-To evaluate the extent of pancreatic beta-cell function in a large number of insulin-dependent diabetic patients with a disease duration of 50 years or longer (Medalists). RESEARCH DESIGN AND METHODS-Characteri... Evaluation of A2BP1 as an Obesity Gene [作者：Ma, LJ; Hanson, RL; Traurig, MT; Muller, YL; Kaur, BP; Perez, JM; Meyre, D; Fu, M; Korner, A; Franks, PW; Kiess, W; Kobes, S; Knowler, WC; Kovacs, P; Froguel, P; Shuldiner, AR; Bogardus, C; Baler, LJ,期刊：Diabetes, 页码：2837-2845 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-A genome-wide association study (GWAS) in Pima Indians (n = 413) identified variation in the ataxin-2 binding protein 1 gene (A2BP1) that was associated with percent body fat. On the basis of this association a... Outstanding Scientific Achievement Award Lecture 2010: Deconstructing Leptin: From Signals to Circuits [作者：Myers, MG,期刊：Diabetes, 页码：2708-2714 , 文章类型： Article，,卷期：2010年59-11] Martin G. Myers Jr., MD, PhD, received the American Diabetes Association's prestigious 2010 Outstanding Scientific Achievement Award at the Association's 70th Scientific Sessions in Orlando, Florida, on 28 June 2010. The... Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight [作者：Kim, HK; Youn, BS; Shin, MS; Namkoong, C; Park, KH; Baik, JH; Kim, JB; Park, JY; Lee, KU; Kim, YB; Kim, MS,期刊：Diabetes, 页码：2772-2780 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-The angiopoietin-like protein 4 (Angptl4)/fasting-induced adipose factor (Fiaf) is known as a regulator of peripheral lipid and glucose metabolism. In the present study, we investigated the physiological role o... Impact of Physical Inactivity on Subcutaneous Adipose Tissue Metabolism in Healthy Young Male Offspring of Patients With Type 2 Diabetes [作者：Hojbjerre, L; Sonne, MP; Alibegovic, AC; Dela, F; Vaag, A; Meldgaard, JB; Christensen, KB; Stallknecht, B,期刊：Diabetes, 页码：2790-2798 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-Physical inactivity is a risk factor for type 2 diabetes and may be more detrimental in first-degree relative (FDR) subjects, unmasking underlying defects of metabolism. Using a positive family history of type ... Cannabinoid Receptor Stimulation Impairs Mitochondrial Biogenesis in Mouse White Adipose Tissue, Muscle, and Liver The Role of eNOS, p38 MAPK, and AMPK Pathways [作者：Tedesco, L; Valerio, A; Dossena, M; Cardile, A; Ragni, M; Pagano, C; Pagotto, U; Carruba, MO; Vettor, R; Nisoli, E,期刊：Diabetes, 页码：2826-2836 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-Cannabinoid type 1 (CB1) receptor is involved in whole-body and cellular energy metabolism. We asked whether CB1 receptor stimulation was able to decrease mitochondrial biogenesis in different metabolically act... Fibrosis in Human Adipose Tissue: Composition, Distribution, and Link With Lipid Metabolism and Fat Mass Loss [作者：Divoux, A; Tordjman, J; Lacasa, D; Veyrie, N; Hugol, D; Aissat, A; Basdevant, A; Guerre-Millo, M; Poitou, C; Zucker, JD; Bedossa, P; Clement, K,期刊：Diabetes, 页码：2817-2825 , 文章类型： Article，,卷期：2010年59-11] OBJECTIVE-Fibrosis is a newly appreciated hallmark of the pathological alteration of human white adipose tissue (WAT). We investigated the composition of subcutaneous (scWAT) and omental WAT (oWAT) fibrosis in obesity an...