- Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans
[作者：Mehta, NN; McGillicuddy, FC; Anderson, PD; Hinkle, CC; Shah, R; Pruscino, L; Tabita-Martinez, J; Sellers, KF; Rickels, MR; Reilly, MP,期刊：Diabetes, 页码：172-181 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-An emerging model of metabolic syndrome and type 2 diabetes is of adipose dysfunction with leukocyte recruitment into adipose leading to chronic inflammation and insulin resistance (IR). This study sought to ex...
- Attenuated Purinergic Receptor Function in Patients With Type 2 Diabetes
[作者：Thaning, P; Bune, LT; Hellsten, Y; Pilegaard, H; Saltin, B; Rosenmeier, JB,期刊：Diabetes, 页码：182-189 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Extracellular nucleotides and nucleosides are involved in regulation of skeletal muscle blood flow. Diabetes induces cardiovascular dysregulation, but the extent to which the vasodilatatory capacity of nucleoti...
- Nephrin Is Expressed on the Surface of Insulin Vesicles and Facilitates Glucose-Stimulated Insulin Release
[作者：Fornoni, A; Jeon, J; Santos, JV; Cobianchi, L; Jauregui, A; Inverardi, L; Mandic, SA; Bark, C; Johnson, K; McNamara, G; Pileggi, A; Molano, RD; Reiser, J; Tryggvason, K; Kerjaschki, D; Berggren, PO; Mundel, P; Ricordi, C,期刊：Diabetes, 页码：190-199 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Nephrin, an immunoglobulin-like protein essential for the function of the glomerular podocyte and regulated in diabetic nephropathy, is also expressed in pancreatic P-cells, where its function remains unknown. ...
- Complement Factor H Is Expressed in Adipose Tissue in Association With Insulin Resistance
[作者：Moreno-Navarrete, JM; Martinez-Barricarte, R; Catalan, V; Sabater, M; Gomez-Ambrosi, J; Ortega, FJ; Ricart, W; Bluher, M; Fruhbeck, G; de Cordoba, SR; Fernandez-Real, JM,期刊：Diabetes, 页码：200-209 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Activation of the alternative pathway of the complement system, in which factor H (fH; complement fH [CFH]) is a key regulatory component, has been suggested as a link between obesity and metabolic disorders. O...
- Chronic Peripheral Hyperinsulinemia in Type 1 Diabetic Patients After Successful Combined Pancreas-Kidney Transplantation Does Not Affect Ectopic Lipid Accumulation in Skeletal Muscle and Liver
[作者：Stadler, M; Anderwald, C; Pacini, G; Zbyn, S; Promintzer-Schifferl, M; Mandl, M; Bischof, M; Gruber, S; Nowotny, P; Luger, A; Prager, R; Krebs, M,期刊：Diabetes, 页码：215-218 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-So far it is unclear whether chronic peripheral hyperinsulinemia per se might contribute to ectopic lipid accumulation and consequently insulin resistance. We investigated the effects of systemic instead of por...
- Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance
[作者：Ye, RS; Jung, DY; Jun, JY; Li, JZ; Luo, SZ; Ko, HJ; Kim, JK; Lee, AS,期刊：Diabetes, 页码：6-16 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-To investigate the role of the endoplasmic reticulum (ER) chaperone glucose-regulated protein (GRP) 78/BiP in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. RESEARCH DESIGN AND METHODS-Ma...
- Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue
[作者：Cheng, Y; Meng, QS; Wang, CX; Li, HK; Huang, ZY; Chen, SH; Xiao, F; Guo, FF,期刊：Diabetes, 页码：17-25 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-White adipose tissue (WAT) and brown adipose tissue (BAT) play distinct roles in adaptation to changes in nutrient availability, with WAT serving as an energy store and BAT regulating thermogenesis. We previous...
- Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated With a Decrease in Fatty Acid Elongases Elovl2 and Elovl4
[作者：Tikhonenko, M; Lydic, TA; Wang, Y; Chen, WQ; Opreanu, M; Sochacki, A; McSorley, KM; Renis, RL; Kern, T; Jump, DB; Reid, GE; Busik, JV,期刊：Diabetes, 页码：219-227 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-The results of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort study revealed a strong association between dyslipidemia and the development of diabet...
- Low Muscle Glycogen and Elevated Plasma Free Fatty Acid Modify but Do Not Prevent Exercise-Induced PDH Activation in Human Skeletal Muscle
[作者：Kiilerich, K; Gudmundsson, M; Birk, JB; Lundby, C; Taudorf, S; Plomgaard, P; Saltin, B; Pedersen, PA; Wojtaszewski, JFP; Pilegaard, H,期刊：Diabetes, 页码：26-32 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-To test the hypothesis that free fatty acid (FFA) and muscle glycogen modify exercise-induced regulation of PDH (pyruvate dehydrogenase) in human skeletal muscle through regulation of PDK4 expression. RESEARCH ...
- Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes
[作者：Hwang, H; Bowen, BP; Lefort, N; Flynn, CR; De Filippis, EA; Roberts, C; Smoke, CC; Meyer, C; Hojlund, K; Yi, ZP; Mandarino, LJ,期刊：Diabetes, 页码：33-42 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Insulin resistance in skeletal muscle is an early phenomenon in the pathogenesis of type 2 diabetes. Studies of insulin resistance usually are highly focused. However, approaches that give a more global picture...
- Adaptive Cerebral Neovascularization in a Model of Type 2 Diabetes Relevance to Focal Cerebral Ischemia
[作者：Li, WG; Prakash, R; Kelly-Cobbs, AI; Ogbi, S; Kozak, A; El-Remessy, AB; Schreihofer, DA; Fagan, SC; Ergul, A,期刊：Diabetes, 页码：228-235 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-The effect of diabetes on neovascularization varies between different organ systems. While excessive angiogenesis complicates diabetic retinopathy, impaired neovascularization contributes to coronary and periph...
- Hippocampal Volumes in Youth With Type 1 Diabetes
[作者：Hershey, T; Perantie, DC; Wu, J; Weaver, PM; Black, KJ; White, NH,期刊：Diabetes, 页码：236-241 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Hippocampal neurons in adult animals and humans are vulnerable to severe hypoglycemia and hyperglycemia. Effects are hypothesized to be exacerbated during development, but existing studies on developing human b...
- Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons
[作者：Sanchez-Alavez, M; Tabarean, IV; Osborn, O; Mitsukawa, K; Schaefer, J; Dubins, J; Holmberg, KH; Klein, I; Klaus, J; Gomez, LF; Kolb, H; Secrest, J; Jochems, J; Myashiro, K; Buckley, P; Hadcock, JR; Eberwine, J; Conti, B; Bartfai, T,期刊：Diabetes, 页码：43-50 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Temperature and nutrient homeostasis are two interdependent components of energy balance regulated by distinct sets of hypothalamic neurons. The objective is to examine the role of the metabolic signal insulin ...
- Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study
[作者：Cheng, S; Massaro, JM; Fox, CS; Larson, MG; Keyes, MJ; McCabe, EL; Robins, SJ; O'Donnell, CJ; Hoffmann, U; Jacques, PF; Booth, SL; Vasan, RS; Wolf, M; Wang, TJ,期刊：Diabetes, 页码：242-248 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Because vitamin D deficiency is associated with a variety of chronic diseases, understanding the characteristics that promote vitamin D deficiency in otherwise healthy adults could have important clinical impli...
- Coadministration of Adenoviral Vascular Endothelial Growth Factor and Angiopoietin-1 Enhances Vascularization and Reduces Ventricular Remodeling in the Infarcted Myocardium of Type 1 Diabetic Rats
[作者：Samuel, SM; Akita, Y; Paul, D; Thiranavukkarasu, M; Zhan, LJ; Sudhakaran, PR; Li, CF; Maulik, N,期刊：Diabetes, 页码：51-60 , 文章类型： Article，,卷期：2010年59-1]
- OBJECTIVE-Hyperglycemia impairs angiogenesis in response to ischemia, leading to ventricular remodeling. Although the effects of overexpressing angiogenic growth factors have been studied in inducing angiogenesis, the fo...
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