- Variants in ASK1 Are Associated With Skeletal Muscle ASK1 Expression, In Vivo Insulin Resistance, and Type 2 Diabetes in Pima Indians
[作者：Bian, L; Hanson, RL; Ossowski, V; Wiedrich, K; Mason, CC; Traurig, M; Muller, YL; Kobes, S; Knowler, WC; Baier, LJ; Bogardus, C,期刊：Diabetes, 页码：1276-1282 , 文章类型： Article，,卷期：2010年59-5]
- OBJECTIVE Prior genome-wide association and exon array expression studies both provided suggestive evidence that apoptosis signal regulating kinase 1 (ASK1) may influence in vivo insulin action in Pima Indians. Genetic v...
- Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction
[作者：Curtis, JM; Grimsrud, PA; Wright, WS; Xu, X; Foncea, RE; Graham, DW; Brestoff, JR; Wiczer, BM; Ilkayeva, O; Cianflone, K; Muoio, DE; Arriaga, EA; Bernlohr, DA,期刊：Diabetes, 页码：1132-1142 , 文章类型： Article，,卷期：2010年59-5]
- OBJECTIVE Peripheral insulin resistance is linked to an increase in reactive oxygen species (ROS), leading in part to the production of reactive lipid aldehydes that modify the side chains of protein amino acids in a rea...
- Vasoactive Intestinal Peptide-Null Mice Demonstrate Enhanced Sweet Taste Preference, Dysglycemia, and Reduced Taste Bud Leptin Receptor Expression
[作者：Martin, B; Shin, YK; White, CM; Ji, S; Kim, W; Carlson, OD; Napora, JK; Chadwick, W; Chapter, M; Waschek, JA; Mattson, MP; Maudsley, S; Egan, JM,期刊：Diabetes, 页码：1143-1152 , 文章类型： Article，,卷期：2010年59-5]
- OBJECTIVE It is becoming apparent that there is a strong link between taste perception and energy homeostasis. Recent evidence implicates gut-related hormones in taste perception, including glucagon-like peptide 1 and va...
- Lipoprotein Particle Size and Concentration by Nuclear Magnetic Resonance and Incident Type 2 Diabetes in Women
[作者：Mora, S; Otvos, JD; Rosenson, RS; Pradhan, A; Buring, JE; Ridker, PM,期刊：Diabetes, 页码：1153-1160 , 文章类型： Article，,卷期：2010年59-5]
- OBJECTIVE Diabetic dyslipoproteinemia is characterized by low HDL cholesterol and high triglycerides. We examined the association of lipoprotein particle size and concentration measured by nuclear magnetic resonance (NMR...
- Dynamic, M2-Like Remodeling Phenotypes of CD11c+Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice
[作者：Shaul, ME; Bennett, G; Strissel, KJ; Greenberg, AS; Obin, MS,期刊：Diabetes, 页码：1171-1181 , 文章类型： Article，,卷期：2010年59-5]
- OBJECTIVE To identify, localize, and determine M1/M2 polarization of epidydimal adipose tissue (eAT) macrophages (Phi(S)) during high-fat diet (HFD)-induced obesity. RESEARCH DESIGN AND METHODS Male C57BL/6 mice were fed...
- Phagocytosis of Enterovirus-Infected Pancreatic beta-Cells Triggers Innate Immune Responses in Human Dendritic Cells
[作者：Schulte, BM; Kramer, M; Ansems, M; Lanke, KHW; van Doremalen, N; Piganelli, JD; Bottino, R; Trucco, M; Galama, JMD; Adema, GJ; van Kuppeveld, FJM,期刊：Diabetes, 页码：1182-1191 , 文章类型： Article，,卷期：2010年59-5]
- OBJECTIVE Type 1 diabetes is a chronic endocrine disorder in which enteroviruses, such as coxsackie B viruses and echoviruses, are possible environmental factors that can trigger or accelerate disease. The development or...
- Progression of Diet-Induced Diabetes in C57BL6J Mice Involves Functional Dissociation of Ca2+ Channels From Secretory Vesicles
[作者：Collins, SC; Hoppa, MB; Walker, JN; Amisten, S; Abdulkader, F; Bengtsson, M; Fearnside, J; Ramracheya, R; Toye, AA; Zhang, Q; Clark, A; Gauguier, D; Rorsman, P,期刊：Diabetes, 页码：1192-1201 , 文章类型： Article，,卷期：2010年59-5]
- OBJECTIVE The aim of the study was to elucidate the cellular mechanism underlying the suppression of glucose-induced insulin secretion in mice fed a high-fat diet (HFD) for 15 weeks. RESEARCH DESIGN AND METHODS-C57BL6J m...
- Unique Arrangement of alpha- and beta-Cells in Human Islets of Langerhans
[作者：Bosco, D; Armanet, M; Morel, P; Niclauss, N; Sgroi, A; Muller, YD; Giovannoni, L; Parnaud, G; Berney, T,期刊：Diabetes, 页码：1202-1210 , 文章类型： Article，,卷期：2010年59-5]
- OBJECTIVE It is generally admitted that the endocrine cell organization in human islets is different from that of rodent islets. However, a clear description of human islet architecture has not yet been reported. The aim...
- Accelerated Increase in Serum Interleukin-1 Receptor Antagonist Starts 6 Years Before Diagnosis of Type 2 Diabetes Whitehall II Prospective Cohort Study
[作者：Carstensen, M; Herder, C; Kivimaki, M; Jokela, M; Roden, M; Shipley, MJ; Witte, DR; Brunner, EJ; Tabak, AG,期刊：Diabetes, 页码：1222-1227 , 文章类型： Article，,卷期：2010年59-5]
- OBJECTIVE Although interleukin-1 receptor antagonist (IL-1Ra) treatment is associated with improved beta-cell function and glycemic control in patients with type 2 diabetes, its role in the development of type 2 diabetes...
- Glucose Intolerance and Reduced Proliferation of Pancreatic beta-Cells in Transgenic Pigs With Impaired Glucose-Dependent Insulinotropic Polypeptide Function
[作者：Renner, S; Fehlings, C; Herbach, N; Hofmann, A; von Waldthausen, DC; Kessler, B; Ulrichs, K; Chodnevskaja, I; Moskalenko, V; Amselgruber, W; Goke, B; Pfeifer, A; Wanke, R; Wolf, E,期刊：Diabetes, 页码：1228-1238 , 文章类型： Article，,卷期：2010年59-5]
- OBJECTIVE The insulinotropic action of the incretin glucose-dependent insulinotropic polypeptide (GIP) is impaired in type 2 diabetes, while the effect of glucagon-like peptide-1 (GLP-1) is preserved. To evaluate the rol...
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