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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共31条记录   Caspase Inhibitor Therapy Synergizes With Costimulation Blockade to Promote Indefinite Islet Allograft Survival [作者：Emamaullee, JA; Davis, J; Pawlick, R; Toso, C; Merani, S; Cai, SX; Tseng, B; Shapiro, AMJ,期刊：Diabetes, 页码：1469-1477 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-Costimulation blockade has emerged as a selective nontoxic maintenance therapy in transplantation. However, these drugs must be combined with other immunomodulatory agents to ensure long-term graft survival. RE... Idd9.2 and Idd9.3 Protective Alleles Function in CD4(+) T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8(+) T-Cells [作者：Hamilton-Williams, EE; Wong, SBJ; Martinez, X; Rainbow, DB; Hunter, KM; Wicker, LS; Sherman, LA,期刊：Diabetes, 页码：1478-1486 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-Multiple type 1 diabetes susceptibility genes have now been identified in both humans and mice, yet mechanistic understanding of how they impact disease pathogenesis is still minimal. We have sought to dissect ... Platelet Tissue Factor Synthesis in Type 2 Diabetic Patients Is Resistant to Inhibition by Insulin [作者：Gerrits, AJ; Koekman, CA; van Haeften, TW; Akkerman, JWN,期刊：Diabetes, 页码：1487-1495 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-Patients with type 2 diabetes have an increased risk of cardiovascular disease and show abnormalities in the coagulation cascade. We investigated whether increased synthesis of tissue factor (TF) by platelets c... High-Mobility Group Box-1 Protein Promotes Angiogenesis After Peripheral Ischemia in Diabetic Mice Through a VEGF-Dependent Mechanism [作者：Biscetti, F; Straface, G; De Cristofaro, R; Lancellotti, S; Rizzo, P; Arena, V; Stigliano, E; Pecorini, G; Egashira, K; De Angelis, G; Ghirlanda, G; Flex, A,期刊：Diabetes, 页码：1496-1505 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-High-mobility group box-1 (HMGB1) protein is a nuclear DNA-binding protein released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. Diabetic human and mouse ti... Extracellular Fatty Acid Synthase: A Possible Surrogate Biomarker of Insulin Resistance [作者：Fernandez-Real, JM; Menendez, JA; Moreno-Navarrete, JM; Bluher, M; Vazquez-Martin, A; Vazquez, MJ; Ortega, F; Dieguez, C; Fruhbeck, G; Ricart, W; Vidal-Puig, A,期刊：Diabetes, 页码：1506-1511 , 文章类型： Article，,卷期：2010年59-6] CONTEXT-Circulating fatty acid synthase (FASN) is a biomarker of metabolically demanding human diseases. The aim of this study was to determine whether circulating FASN could be a biomarker of overnutrition-induced metab... Cardiac-Specific IGF-1 Receptor Transgenic Expression Protects Against Cardiac Fibrosis and Diastolic Dysfunction in a Mouse Model of Diabetic Cardiomyopathy [作者：Huynh, K; McMullen, JR; Julius, TL; Tan, JW; Love, JE; Cemerlang, N; Kiriazis, H; Du, XJ; Ritchie, RH,期刊：Diabetes, 页码：1512-1520 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-Compelling epidemiological and clinical evidence has identified a specific cardiomyopathy in diabetes, characterized by early diastolic dysfunction and adverse structural remodeling. Activation of the insulin-l... Influence of Insulin in the Ventromedial Hypothalamus on Pancreatic Glucagon Secretion In Vivo [作者：Paranjape, SA; Chan, O; Zhu, WL; Horblitt, AM; McNay, EC; Cresswell, JA; Bogan, JS; McCrimmon, RJ; Sherwin, RS,期刊：Diabetes, 页码：1521-1527 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-Insulin released by the beta-cell is thought to act locally to regulate glucagon secretion. The possibility that insulin might also act centrally to modulate islet glucagon secretion has received little attenti... Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db Mice Role of NADPH Oxidase 4 [作者：Li, JM; Wang, JJ; Yu, QA; Chen, K; Mahadev, K; Zhang, SX,期刊：Diabetes, 页码：1528-1538 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-Oxidative stress is a key pathogenic factor in diabetic retinopathy. We previously showed that lovastatin mitigates blood-retinal barrier (BRB) breakdown in db/db mice. The purpose of this study is to determine... MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans [作者：Andersson, EA; Holst, B; Sparso, T; Grarup, N; Banasik, K; Holmkvist, J; Jorgensen, T; Borch-Johnsen, K; Egerod, KL; Lauritzen, T; Sorensen, TIA; Bonnefond, A; Meyre, D; Froguel, P; Schwartz, TW; Pedersen, O; Hansen, T,期刊：Diabetes, 页码：1539-1548 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-Common variants in the melatonin receptor type 1B (MTNR1B) locus have been shown to increase fasting plasma glucose (FPG) and the risk of type 2 diabetes. The aims of this study were to evaluate whether nonsyno... FTO Genetic Variation and Association With Obesity in West Africans and African Americans [作者：Adeyemo, A; Chen, GJ; Zhou, J; Shriner, D; Doumatey, A; Huang, HX; Rotimi, C,期刊：Diabetes, 页码：1549-1554 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-The FTO gene is one of the most consistently replicated loci for obesity. However, data from populations of African ancestry are limited. We evaluated genetic variation in the FTO gene and investigated associat... Islet Transplantation a Decade Later and Strategies for Filling a Half-Full Glass [作者：Robertson, RP,期刊：Diabetes, 页码：1285-1291 , 文章类型： Article，,卷期：2010年59-6] Alloislet transplantation for the treatment of type 1 diabetes enjoyed highly favorable status in the first half of the last decade but declined in favor during the second half. In this Perspective, I will briefly review... Local Non-Esterified Fatty Acids Correlate With Inflammation in Atheroma Plaques of Patients With Type 2 Diabetes [作者：Mas, S; Martinez-Pinna, R; Martin-Ventura, JL; Perez, R; Gomez-Garre, D; Ortiz, A; Fernandez-Cruz, A; Vivanco, F; Egido, J,期刊：Diabetes, 页码：1292-1301 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-Atherosclerosis is prevalent in diabetic patients, but there is little information on the localization of nonesterified fatty acids (NEFAs) within the plaque and their relationship with inflammation. We sought ... Association Between CNDP1 Genotype and Diabetic Nephropathy Is Sex Specific [作者：Mooyaart, AL; Zutinic, A; Bakker, SJL; Grootendorst, DC; Kleefstra, N; van Valkengoed, IGM; Bohringer, S; Bilo, HJG; Dekker, FW; Bruijn, JA; Navis, G; Janssen, B; Baelde, HJ; De Heer, E,期刊：Diabetes, 页码：1555-1559 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-The 5-5 homozygous CNDP1 (carnosinase) genotype is associated with a reduced risk of diabetic nephropathy. We investigated whether this association is sex specific and independent of susceptibility for type 2 d... Molecular Characterization of Insulin-Mediated Suppression of Hepatic Glucose Production In Vivo [作者：Ramnanan, CJ; Edgerton, DS; Rivera, N; Irimia-Dominguez, J; Farmer, B; Neal, DW; Lautz, M; Donahue, EP; Meyer, CM; Roach, PJ; Cherrington, AD,期刊：Diabetes, 页码：1302-1311 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-Insulin-mediated suppression of hepatic glucose production (HGP) is associated with sensitive intracellular signaling and molecular inhibition of gluconeogenic (GNG) enzyme mRNA expression. We determined, for t... PTEN Inhibition Improves Muscle Regeneration in Mice Fed a High-Fat Diet [作者：Hu, ZY; Wang, HL; Lee, IH; Modi, S; Wang, XA; Du, J; Mitch, WE,期刊：Diabetes, 页码：1312-1320 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-Mechanisms impairing wound healing in diabetes are poorly understood. To identify mechanisms, we induced insulin resistance by chronically feeding mice a high-fat diet (HFD). We also examined the regulation of ... Glycerol-3-Phosphate Acyltransferase 1 Deficiency in ob/ob Mice Diminishes Hepatic Steatosis but Does Not Protect Against Insulin Resistance or Obesity [作者：Wendel, AA; Li, LO; Li, Y; Cline, GW; Shulman, GI; Coleman, RA,期刊：Diabetes, 页码：1321-1329 , 文章类型： Article，,卷期：2010年59-6] OBJECTIVE-Hepatic steatosis is strongly associated with insulin resistance, but a causal role has not been established. In ob/ob mice, sterol regulatory element binding protein 1 (SREBP1) mediates the induction of steato...