- The viral protein Egf1.0 is a dual activity inhibitor of prophenoloxidase-activating proteinases 1 and 3 from Manduca sexta
[作者:Lu, Z; Beck, MH; Wang, Y; Jiang, H; Strand, MR,期刊:Journal of Biological Chemistry, 页码:21325-21333 , 文章类型: Article,,卷期:2008年283-31]
- Some pathogens are capable of suppressing the melanization response of host insects, but the virulence factors responsible are largely unknown. The insect pathogen Microplitis demolitor bracovirus encodes the Egf family ...
- Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28
[作者:Piskounova, E; Viswanathan, SR; Janas, M; LaPierre, RJ; Daley, GQ; Sliz, P; Gregory, RI,期刊:Journal of Biological Chemistry, 页码:21310-21314 , 文章类型: Article,,卷期:2008年283-31]
- The developmentally regulated RNA-binding protein Lin28 blocks processing of let-7 family microRNAs (miRNAs) in embryonic cells. The molecular basis for this selective miRNA processing block is unknown. Here we find that...
- Antagonistic effects of the SRp30c protein and cryptic 5 ' splice sites on the alternative splicing of the apoptotic regulator Bcl-x
[作者:Cloutier, P; Toutant, J; Shkreta, L; Goekjian, S; Revil, TE; Chabot, B,期刊:Journal of Biological Chemistry, 页码:21315-21324 , 文章类型: Article,,卷期:2008年283-31]
- Alternative 5' splice site selection allows Bcl-x to produce two isoforms with opposite effects on apoptosis. The pro-apoptotic Bcl-x(S) variant is up-regulated by ceramide and down-regulated by protein kinase C through ...
- Site-specific cleavage of G protein-coupled receptor-engaged beta-arrestin - Influence of the AT(1) receptor conformation on scissile site selection
[作者:Lee, CW; Bhatt, S; Shukla, A; Desnoyer, RW; Yadav, SP; Kim, M; Jang, SH; Karnik, SS,期刊:Journal of Biological Chemistry, 页码:21612-21620 , 文章类型: Article,,卷期:2008年283-31]
- The discovery of beta-arrestin-related similar to 46-kDa polypeptide in transfected cells and mouse hearts led us to examine angiotensin II type 1 receptor (AT(1)R)-dependent proteolytic cleavage of beta-arrestin(s). Rec...
- Neuronally selective mu-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels
[作者:Schroeder, CI; Ekberg, J; Nielsen, KJ; Adams, D; Loughnan, ML; Thomas, L; Adams, DJ; Alewood, PF; Lewis, RJ,期刊:Journal of Biological Chemistry, 页码:21621-21628 , 文章类型: Article,,卷期:2008年283-31]
- mu-Conotoxins are small peptide inhibitors of muscle and neuronal tetrodotoxin (TTX)-sensitive voltage-gated sodium channels (VGSCs). Here we report the isolation of mu-conotoxins SIIIA and SIIIB by I-125-TIIIA-guided fr...
- The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
[作者:Aqeilan, RI; Hassan, MQ; de Bruin, A; Hagan, JP; Volinia, S; Palumbo, T; Hussain, S; Lee, SH; Gaur, T; Stein, GS; Lian, JB; Croce, CM,期刊:Journal of Biological Chemistry, 页码:21629-21639 , 文章类型: Article,,卷期:2008年283-31]
- The WW domain-containing oxidoreductase ( WWOX) gene encodes a tumor suppressor. We have previously shown that targeted ablation of the Wwox gene in mouse increases the incidence of spontaneous and chemically induced tum...
- Dedicated metallochaperone connects apoenzyme and molybdenum cofactor biosynthesis components
[作者:Genest, O; Neumann, M; Seduk, F; Stocklein, W; Mejean, V; Leimkuhler, S; Iobbi-Nivol, C,期刊:Journal of Biological Chemistry, 页码:21433-21440 , 文章类型: Article,,卷期:2008年283-31]
- The biogenesis of molybdenum-containing enzymes is a sophisticated process involving the insertion of a complex molybdenum cofactor into competent apoproteins. As for many molybdoenzymes, the maturation of trimethylamine...
- Cooperative DNA binding and communication across the dimer interface in the TREX2 3 '-> 5 '-exonuclease
[作者:Perrino, FW; de Silva, U; Harvey, S; Pryor, EE; Cole, DW; Hollis, T,期刊:Journal of Biological Chemistry, 页码:21441-21452 , 文章类型: Article,,卷期:2008年283-31]
- The activity of human TREX2-catalyzed 3' -> 5'-deoxyribonuclease has been analyzed in steady-state and single turnover kinetic assays and in equilibrium DNA binding studies. These kinetic data provide evidence for cooper...
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