- Group IVA phospholipase A(2) is necessary for the biogenesis of lipid droplets
[作者:Gubern, A; Casas, J; Barcelo-Torns, M; Barneda, D; de la Rosa, X; Masgrau, R; Picatoste, F; Balsinde, J; Balboa, MA; Claro, E,期刊:Journal of Biological Chemistry, 页码:27369-27382 , 文章类型: Article,,卷期:2008年283-41]
- Lipid droplets (LD) are organelles present in all cell types, consisting of a hydrophobic core of triacylglycerols and cholesteryl esters, surrounded by a monolayer of phospholipids and cholesterol. This work shows that ...
- Macromolecular crowding compacts unfolded apoflavodoxin and causes severe aggregation of the off-pathway intermediate during apoflavodoxin folding
[作者:Engel, R; Westphal, AH; Huberts, DHEW; Nabuurs, SM; Lindhoud, S; Visser, AJWG; van Mierlo, CPM,期刊:Journal of Biological Chemistry, 页码:27383-27394 , 文章类型: Article,,卷期:2008年283-41]
- To understand how proteins fold in vivo, it is important to investigate the effects of macromolecular crowding on protein folding. Here, the influence of crowding on in vitro apoflavodoxin folding, which involves a relat...
- Mutational analysis of the helicase-like domain of Thermotoga maritima reverse gyrase
[作者:de la Tour, CB; Amrani, L; Cossard, R; Neuman, KC; Serre, MC; Duguet, M,期刊:Journal of Biological Chemistry, 页码:27395-27402 , 文章类型: Article,,卷期:2008年283-41]
- Reverse gyrase is a unique type IA topoisomerase that is able to introduce positive supercoils into DNA in an ATP-dependent process. ATP is bound to the helicase-like domain of the enzyme that contains most of the conser...
- Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal
[作者:Rossi, ML; Pike, JE; Wang, W; Burgers, PMJ; Campbell, JL; Bambara, RA,期刊:Journal of Biological Chemistry, 页码:27483-27493 , 文章类型: Article,,卷期:2008年283-41]
- Eukaryotic Okazaki fragment maturation requires complete removal of the initiating RNA primer before ligation occurs. Polymerase delta (Pol delta) extends the upstream Okazaki fragment and displaces the 5'-end of the dow...
- Regulation of the PDK4 isozyme by the Rb-E2F1 complex
[作者:Hsieh, MCF; Das, D; Sambandam, N; Zhang, MQ; Nahle, Z,期刊:Journal of Biological Chemistry, 页码:27410-27417 , 文章类型: Article,,卷期:2008年283-41]
- Loss of the transcription factor E2F1 elicits a complex metabolic phenotype in mice underscored by reduced adiposity and protection from high fat diet-induced diabetes. Here, we demonstrate that E2F1 directly regulates t...
- Regulation of telomere length by fatty acid elongase 3 in yeast - Involvement of inositol phosphate metabolism and Ku70/80 function
[作者:Ponnusamy, S; Alderson, NL; Hama, H; Bielawski, J; Jiang, JC; Bhandari, R; Snyder, SH; Jazwinski, SM; Ogretmen, B,期刊:Journal of Biological Chemistry, 页码:27514-27524 , 文章类型: Article,,卷期:2008年283-41]
- In this study, we investigated the roles of very long-chain fatty acid (VLCFA) synthesis by fatty acid elongase 3 (ELO3) in the regulation of telomere length and life span in the yeast Saccharomyces cerevisiae. Loss of V...
- An obligatory heterodimer of 14-3-3 beta and 14-3-3 epsilon is required for aldosterone regulation of the epithelial sodium channel
[作者:Liang, XB; Butterworth, MB; Peters, KW; Walker, WH; Frizzell, RA,期刊:Journal of Biological Chemistry, 页码:27418-27425 , 文章类型: Article,,卷期:2008年283-41]
- Increased distal nephron sodium absorption in response to aldosterone involves Nedd4-2 phosphorylation, which blocks its ability to ubiquitylate ENaC and increases apical membrane channel density by reducing its endocyto...
- Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel
[作者:Xia, R; Mei, ZZ; Mao, HJ; Yang, W; Dong, L; Bradley, H; Beech, DJ; Jiang, LH,期刊:Journal of Biological Chemistry, 页码:27426-27432 , 文章类型: Article,,卷期:2008年283-41]
- The molecular basis for divalent cationic permeability in transient receptor potential melastatin subtype ( TRPM) channels is not fully understood. Here we studied the roles of all eight acidic residues, glutamate or asp...
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