- History of Peptic Ulcer Disease and Pancreatic Cancer Risk in Men
[作者:Bao, Y; Spiegelman, D; Li, RF; Giovannucci, E; Fuchs, CS; Michaud, DS,期刊:Gastroenterology, 页码:541-549 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Peptic ulcer disease has been associated with an increased risk of pancreatic cancer, but findings on this topic are inconsistent. We investigated the association between pancreatic cancer and the occu...
- CDX Transcription Factors Positively Regulate Expression of Solute Carrier Family 5, Member 8 in the Colonic Epithelium
[作者:Kakizaki, F; Aoki, K; Miyoshi, H; Carrasco, N; Aoki, M; Taketo, MM,期刊:Gastroenterology, 页码:627-635 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Caudal-related homeodomain transcription factors CDX1 and CDX2 regulate gut development and differentiation of intestinal epithelial cells; they are candidate tumor suppressors of colorectal carcinomas...
- Mesalamine Inhibits Epithelial beta-Catenin Activation in Chronic Ulcerative Colitis
[作者:Brown, JB; Lee, G; Managlia, E; Grimm, GR; Dirisina, R; Goretsky, T; Cheresh, P; Blatner, NR; Khazaie, K; Yang, GY; Li, LH; Barrett, TA,期刊:Gastroenterology, 页码:595-U238 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Mesalamine is a mainstay therapeutic agent in chronic ulcerative colitis (CUC) in which condition it reverses crypt architectural changes and reduces colitis-associated cancer (CAC). The present study ...
- Des-gamma-Carboxy Prothrombin and alpha-Fetoprotein as Biomarkers for the Early Detection of Hepatocellular Carcinoma
[作者:Lok, AS; Sterling, RK; Everhart, JE; Wright, EC; Hoefs, JC; Di Bisceglie, AM; Morgan, TR; Kim, HY; Lee, WM; Bonkovsky, HL; Dienstag, JL,期刊:Gastroenterology, 页码:493-502 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: The outcome of patients with hepatocellular carcinoma (HCC) remains poor because of late diagnosis. The aim of this study was to compare the accuracy of alpha-fetoprotein (AFP) and des-gamma-carboxy pr...
- Inhibition of HDAC9 Increases T Regulatory Cell Function and Prevents Colitis in Mice
[作者:de Zoeten, EF; Wang, LQ; Sai, H; Dillmann, WH; Hancock, WW,期刊:Gastroenterology, 页码:583-594 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Foxp3+ T regulatory cells (Tregs) help prevent autoimmunity, and increases in their numbers of functions could decrease the development of inflammatory bowel disease. Like other cells, Foxp3+ Tregs exp...
- Lysophosphatidic Acid Stimulates the Intestinal Brush Border Na+/H+ Exchanger 3 and Fluid Absorption via LPA(5) and NHERF2
[作者:Lin, SB; Yeruva, S; He, PJ; Singh, AK; Zhang, HC; Chen, MM; Lamprecht, G; de Jonge, HR; Tse, M; Donowitz, M; Hogema, BM; Chun, J; Seidler, U; Yun, CC,期刊:Gastroenterology, 页码:649-658 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Diarrhea results from reduced net fluid and salt absorption caused by an imbalance in intestinal absorption and secretion. The bulk of sodium and water absorption in the intestine is mediated by Na+/H+...
- Loss of Parietal Cell Expression of Sonic Hedgehog Induces Hypergastrinemia and Hyperproliferation of Surface Mucous Cells
[作者:Xiao, C; Ogle, SA; Schumacher, MA; Orr-Asman, MA; Miller, ML; Lertkowit, N; Varro, A; Hollande, F; Zavros, Y,期刊:Gastroenterology, 页码:550-U189 , 文章类型: Article,,卷期:2010年138-2]
- BACKGROUND & AIMS: Sonic Hedgehog (Shh) is expressed in the adult stomach, but its role as a gastric morphogen is unclear. We sought to identify mechanisms by which Shh might regulate gastric epithelial cell function and...
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