- Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides.
[作者:Eilfeld, Alexander;Gonzalez Tanarro, Camino M.;Frizler, Maxim;Sieler, Joachim;Schulze, Baerbel;Guetschow, Michael;,期刊:Bioorganic & Medicinal Chemistry, 页码:8127-8135 , 文章类型: 研究论文,,卷期:2008年16-17]
- The synthesis of a series of new isothiazol-3(2H)-one 1,1-dioxides with halogenated (mostly fluorinated) pyridinyl and pentafluorophenyl substituents at 2-position is reported. These compds. (18-24) became easily access...
- Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors.
[作者:Qiu, Xu;Liu, Zhong;Shao, Wei-Yan;Liu, Xing;Jing, Da-Ping;Yu, Yan-Jun;An, Lin-Kun;Huang, Shi-Liang;Bu, Xian-Zhang;Huang, Zhi-Shu;Gu, Lian-Quan;,期刊:Bioorganic & Medicinal Chemistry, 页码:8035-8041 , 文章类型: 研究论文,,卷期:2008年16-17]
- Series of curcumin derivs. were synthesized; the inhibitory activities on thioredoxin reductase (TrxR) of all analogs were evaluated by DTNB assay in vitro. It is found that most of the analogs can inhibit TrxR in the l...
- Cyclic voltammetric analysis of 2-styrylchromones: Relationship with the antioxidant activity.
[作者:Gomes, Ana;Fernandes, Eduarda;Garcia, M. Beatriz Q.;Silva, Artur M. S.;Pinto, Diana C. G. A.;Santos, Clementina M. M.;Cavaleiro, Jose A. S.;Lima, Jose L. F. C.;,期刊:Bioorganic & Medicinal Chemistry, 页码:7939-7943 , 文章类型: 研究论文,,卷期:2008年16-17]
- compds., vinyl analogs of flavones (2-phenylchromones), whose occurrence in nature has been reported. Recently, several 2-SC derivs. were demonstrated to have antioxidant properties, namely, xanthine oxidase inhibition,...
- A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial.
[作者:Alvey, Luke;Prado, Soizic;Huteau, Valerie;Saint-Joanis, Brigitte;Michel, Sylvie;Koch, Michel;Cole, Stewart T.;Tillequin, Francois;Janin, Yves L.;,期刊:Bioorganic & Medicinal Chemistry, 页码:8264-8272 , 文章类型: 研究论文,,卷期:2008年16-17]
- From the structure of 3,3-dimethyl-3H-benzofuro[3,2-f][1]-benzopyran, a selective in vitro inhibitor of mycobacterial growth, a structure-activity relationship investigation has been undertaken. Reported here are the re...
- Synthesis, structural studies and biological properties of new TBA analogues containing an acyclic nucleotide.
[作者:Coppola, Teresa;Varra, Michela;Oliviero, Giorgia;Galeone, Aldo;D'Isa, Giuliana;Mayol, Luciano;Morelli, Elena;Bucci, Maria-Rosaria;Vellecco, Valentina;Cirino, Giuseppe;Borbone, Nicola;,期刊:Bioorganic & Medicinal Chemistry, 页码:8244-8253 , 文章类型: 研究论文,,卷期:2008年16-17]
- A new modified acyclic nucleoside, namely N 1-(3-hydroxy-2-hydroxymethyl-2-methylpropyl)-thymidine, was synthesized and transformed into a building block useful for oligonucleotide (ON) automated synthesis. A series of ...
- Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities.
[作者:Kumano, Takuto;Richard, Stephane B.;Noel, Joseph P.;Nishiyama, Makoto;Kuzuyama, Tomohisa;,期刊:Bioorganic & Medicinal Chemistry, 页码:8117-8126 , 文章类型: 研究论文,,卷期:2008年16-17]
- NphB is a sol. prenyltransferase from Streptomyces sp. strain CL190 that attaches a geranyl group to a 1,3,6,8-tetrahydroxynaphthalene-derived polyketide during the biosynthesis of anti-oxidant naphterpin. Here we repor...
- Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase.
[作者:Musilek, Kamil;Kucera, Jiri;Jun, Daniel;Dohnal, Vlastimil;Opletalova, Veronika;Kuca, Kamil;,期刊:Bioorganic & Medicinal Chemistry, 页码:8218-8223 , 文章类型: 研究论文,,卷期:2008年16-17]
- of organophosphate intoxication. Eighteen monoquaternary reactivators of acetylcholinesterase with modified side chain were developed in an effort to extend the properties of pralidoxime. The known reactivators (pralid...
- Identification of SVM-based classification model, synthesis and evaluation of prenylated flavonoids as vasorelaxant agents.
[作者:Dong, Xiaowu;Liu, Yujie;Yan, Jingying;Jiang, Chaoyi;Chen, Jing;Liu, Tao;Hu, Yongzhou;,期刊:Bioorganic & Medicinal Chemistry, 页码:8151-8160 , 文章类型: 研究论文,,卷期:2008年16-17]
- Support vector machine (SVM) was applied to predict vasorelaxation effect of different structural mols. A good classification model had been established, and the accuracy in prediction for the training, test, and overal...
- Synthesis and structure-activity relationship studies of theophylline analogs on population responses in the rat hippocampus in vitro.
[作者:Ananthalakshmi, Kethireddy V. V.;Bartl, Tomas;Aziza, Mohammed H.;Novotny, Ladislav;Marek, Radek;Benes, Ludek;Kombian, Samuel B.;,期刊:Bioorganic & Medicinal Chemistry, 页码:8142-8150 , 文章类型: 研究论文,,卷期:2008年16-17]
- We synthesized several theophylline analogs and tested the hypothesis that these compds. may be nootropic or cognitive enhancers by examg. their effects on evoked population spikes recorded extracellularly in the CA1 reg...
- Synthesis and antiproliferative activity in vitro of novel (2-butynyl)thioquinolines.
[作者:Mol, W.;Matyja, M.;Filip, B.;Wietrzyk, J.;Boryczka, S.;,期刊:Bioorganic & Medicinal Chemistry, 页码:8136-8141 , 文章类型: 研究论文,,卷期:2008年16-17]
- The series of new acetylenic thioquinolines contg. propargyl, 2-butynyl, 4-bromo-2-butynyl, and 4-hydroxy-2-butynyl groups has been prepd. and tested for antiproliferative activity in vitro against human [SW707 (colorect...
- Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone.
[作者:Kiviranta, Paeivi H.;Salo, Heikki S.;Leppaenen, Jukka;Rinne, Valtteri M.;Kyrylenko, Sergiy;Kuusisto, Erkki;Suuronen, Tiina;Salminen, Antero;Poso, Antti;Lahtela-Kakkonen, Maija;Wallen, Erik A. A.;,期刊:Bioorganic & Medicinal Chemistry, 页码:8054-8062 , 文章类型: 研究论文,,卷期:2008年16-17]
- SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone were studied. This backbone has been developed in the group, and it is derived from a compd. originally found by virtual screening. In addn., co...
- Hybridization-dependent fluorescence of oligodeoxynucleotides incorporating new pyrene-modified adenosine residues.
[作者:Seio, Kohji;Mizuta, Masanhiro;Tasaki, Kaori;Tamaki, Keigo;Ohkubo, Akihiro;Sekine, Mitsuo;,期刊:Bioorganic & Medicinal Chemistry, 页码:8287-8293 , 文章类型: 研究论文,,卷期:2008年16-17]
- We report the synthesis and properties of oligonucleotides incorporating N 6-[N-(pyren-1-ylmethyl)carbamoyl]-deoxyadenosine (dApymcm). We designed the ODN which incorporated two consecutive dApymcm residues. It was rev...
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