- A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculature in vivo
[作者:Villa, A; Trachsel, E; Kaspar, M; Schliemann, C; Sommavilla, R; Rybak, JN; Rosli, C; Borsi, L; Neri, D,期刊:International Journal of Cancer, 页码:2405-2413 , 文章类型: Article,,卷期:2008年122-11]
- The alternatively spliced extra-domain B of fibronectin is one of the best characterized markers of tumor angiogenesis. Similarly, the extra-domain A (EDA), which can also be inserted in the fibronectin transcript by a m...
- Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies
[作者:Jeyapalan, JN; Mendez-Bermudez, A; Zaffaroni, N; Dubrova, YE; Royle, NJ,期刊:International Journal of Cancer, 页码:2414-2421 , 文章类型: Article,,卷期:2008年122-11]
- Immortalized and cancer cells maintain their telomeres by activation of a telomere maintenance mechanism (TMM). In similar to 85% of cancers telomerase is activated (TA) but in some tumours, in particular sarcomas, an al...
- Metastasis is promoted by a bioenergetic switch: New targets for progressive renal cell cancer
[作者:Langbein, S; Frederiks, WM; zur Hansen, A; Popa, J; Lehmann, J; Weiss, C; Alken, P; Coy, JF,期刊:International Journal of Cancer, 页码:2422-2428 , 文章类型: Article,,卷期:2008年122-11]
- Targeted therapies have demonstrated clinical benefit with limited impact on long-term disease specific survival in the treatment of renal cell cancer (RCC). New opportunities for the treatment of tumors that are resista...
- V gamma 9V delta 2 T cell cytotoxicity against tumor cells is enhanced by monoclonal antibody drugs - Rituximab and trastuzumab
[作者:Tokuyama, H; Hagi, T; Mattarollo, SR; Morley, J; Wang, Q; Fai-So, H; Moriyasu, F; Nieda, M; Nicol, AJ,期刊:International Journal of Cancer, 页码:2526-2534 , 文章类型: Article,,卷期:2008年122-11]
- V gamma 9V delta 2 T cells exert potent cytotoxicity toward various tumor cells and adoptive transfer of V gamma 9V delta 2 T cells is an attractive proposition for cell based immunotherapy. V gamma 9V delta 2 T cells ex...
- Gastric cancer cells exploit CD4+cell-derived CCL5 for their growth and prevention of CD8+cell-involved tumor elimination
[作者:Sugasawa, H; Ichikura, T; Kinoshita, M; Ono, S; Majima, T; Tsujimoto, H; Chochi, K; Hiroi, S; Takayama, E; Saitoh, D; Seki, S; Mochizuki, H,期刊:International Journal of Cancer, 页码:2535-2541 , 文章类型: Article,,卷期:2008年122-11]
- The level of serum CCL5, a C-C chemokine, is reportedly correlated with tumor progression in several cancers. We herein investigated the mechanisms by which CCL5 might contribute to tumor progression in gastric cancer. S...
- The DNA demethylating agent 5-aza-2'-deoxycytidine activates NY-ESO-1 antigenicity in orthotopic human glioma
[作者:Natsume, A; Wakabayashi, T; Tsujimura, K; Shimato, S; Ito, M; Kuzushima, K; Kondo, Y; Sekido, Y; Kawatsura, H; Narita, Y; Yoshida, J,期刊:International Journal of Cancer, 页码:2542-2553 , 文章类型: Article,,卷期:2008年122-11]
- Cancer/testis antigens (CTAs) are considered to be suitable targets for the immunotherapy of human malignancies. It has been demonstrated that in a variety of tumors, the expression of certain CTAs is activated via the d...
- Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival
[作者:Luo, JH; Xie, D; Liu, MZ; Chen, W; Liu, YD; Wu, GQ; Kung, HF; Zeng, YX; Guan, XY,期刊:International Journal of Cancer, 页码:2554-2561 , 文章类型: Article,,卷期:2008年122-11]
- AIB1, a candidate oncogene in human breast cancer, is frequently amplified and overexpressed in several types of human cancers, but the status of AIB1 amplification and expression in urothelial carcinoma of the bladder (...
- Intra-operative rapid diagnostic method based on CK19 mRNA expression for the detection of lymph node metastases in breast cancer
[作者:Visser, M; Jiwa, M; Horstman, A; Brink, AATP; Pol, RP; van Diest, P; Snijders, PJF; Meijer, CJLM,期刊:International Journal of Cancer, 页码:2562-2567 , 文章类型: Article,,卷期:2008年122-11]
- Staging by sentinel node (SN) biopsy is the standard procedure for clinically node-negative breast cancer patients. Intra-operative analysis of the SN allows immediate axillary lymph node (ALN) dissection in SN positive ...
- Methylation pattern of the O-6 -methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis
[作者:Nagasaka, T; Goel, A; Notohara, K; Takahata, T; Sasamoto, H; Uchida, T; Nishida, N; Tanaka, N; Boland, CR; Matsubara, N,期刊:International Journal of Cancer, 页码:2429-2436 , 文章类型: Article,,卷期:2008年122-11]
- O-6 -methylguanine-DNA methyltransferase (MGMT) is a DNA repair gene which is frequently methylated in colorectal cancer (CRC). However, it remains controversial whether methylation of specific CpG sequences within MGMT ...
- Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc(Min/+) colon epithelial cells
[作者:Fenton, JI; Birmingham, JM; Hursting, SD; Hord, NG,期刊:International Journal of Cancer, 页码:2437-2445 , 文章类型: Article,,卷期:2008年122-11]
- We previously demonstrated that leptin, an adipose-derived hormone, induces cell proliferation in a model of preneoplastic (IMCE (Apc(Min/+)), but not normal (YAMC (Ape(+/+)), colon epithelial cells by inducing autocrine...
- Tenascin-W, a new marker of cancer stroma, is elevated in sera of colon and breast cancer patients
[作者:Degen, M; Brellier, F; Schenk, S; Driscoll, R; Zaman, K; Stupp, R; Tornillo, L; Terracciano, L; Chiquet-Ehrismann, R; Rugg, C; Seelentag, W,期刊:International Journal of Cancer, 页码:2454-2461 , 文章类型: Article,,卷期:2008年122-11]
- Tenascins are extracellular matrix proteins present during the development of organisms as well as in pathological conditions. Tenascin-W, the fourth and last member of the tenascin family remains the least well -charact...
- Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon
[作者:Calcagno, SR; Li, SH; Colon, M; Kreinest, PA; Thompson, EA; Fields, AP; Murray, NR,期刊:International Journal of Cancer, 页码:2462-2470 , 文章类型: Article,,卷期:2008年122-11]
- Oncogenic K-ras mutations are frequently observed in colon cancers and contribute to transformed growth. Oncogenic K-ras is detected in aberrant crypt foci (ACF), precancerous colonic lesions, demonstrating that acquisit...
- VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma
[作者:Thelen, A; Scholz, A; Benckert, C; von Marschal, Z; Schroder, M; Wiedenmann, B; Neuhaus, P; Rosewicz, S; Jonas, S,期刊:International Journal of Cancer, 页码:2471-2481 , 文章类型: Article,,卷期:2008年122-11]
- Lymphatic spread is an important clinical determinant for the prognosis of hepatocellular carcinoma (HCC), but little is known about the control of lymphangiogenesis in HCC. We addressed expression and biological role of...
- Bone marrow stromal cells enhance prostate cancer cell invasion through type I collagen in an MMP-12 dependent manner
[作者:Nabha, SM; dos Santos, EB; Yamamoto, HA; Belizi, A; Dong, Z; Meng, H; Saliganan, A; Sabbota, A; Bonfil, RD; Cher, ML,期刊:International Journal of Cancer, 页码:2482-2490 , 文章类型: Article,,卷期:2008年122-11]
- At the cellular level, the process of bone metastasis involves many steps. Circulating cancer cells enter the marrow, proliferate, induce neovascularization, and ultimately expand into a clinically detectable, often symp...
- Difference in characteristics of APC mutations between colonic and extracolonic tumors of FAP patients: Variations with phenotype
[作者:Miyaki, M; Yamaguchi, T; Iijima, T; Takahashi, K; Matsmuoto, H; Yasutome, M; Funata, N; Mori, T,期刊:International Journal of Cancer, 页码:2491-2497 , 文章类型: Article,,卷期:2008年122-11]
- To clarify the differences in characteristics of adenomatous polyposis coli (APC) mutations between colorectal tumors from various phenotypes of familial adenomatous polyposis (FAP) and between colorectal and extracoloni...
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