- Apple polyphenols modulate expression of selected genes related to toxicological defence and stress response in human colon adenoma cells
[作者:Veeriah, S; Miene, C; Habermann, N; Hofmann, T; Klenow, S; Sauer, J; Bohmer, F; Wolfl, S; Pool-Zobel, BL,期刊:International Journal of Cancer, 页码:2647-2655 , 文章类型: Article,,卷期:2008年122-12]
- Apples contain significant amounts of flavonoids that are potentially cancer risk reducing by acting antioxidative or antiproliferative and by favorably modulating gene expression. The purpose of this study was to invest...
- Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas
[作者:Hafkamp, HC; Manni, JJ; Haesvoets, A; Voogd, AC; Schepers, M; Bot, FJ; Hopman, AHN; Ramaekers, FCS; Speel, EJM,期刊:International Journal of Cancer, 页码:2656-2664 , 文章类型: Article,,卷期:2008年122-12]
- Oncogenic human papillomavirus (HPV) is a causative agent in a subgroup of head and neck carcinomas, particularly tonsillar squamous cell carcinomas (TSCC). This study was undertaken because controversial data exist on t...
- Src kinase induces tumor formation in the c-SRC C57BL/6 mouse
[作者:Kline, CLB; Jackson, R; Engelman, R; Pledger, WJ; Yeatman, TJ; Irby, RB,期刊:International Journal of Cancer, 页码:2665-2673 , 文章类型: Article,,卷期:2008年122-12]
- Src kinase has been linked as a causative agent in the progression of a number of cancers including colon, breast, lung and melanoma. Src protein and activity levels are increased in colorectal cancer and liver metastase...
- Platycodin D induces mitotic arrest in vitro, leading to endoreduplication, inhibition of proliferation and apoptosis in leukemia cells
[作者:Kim, MO; Moon, DO; Choi, YH; Lee, JD; Kim, ND; Kim, GY,期刊:International Journal of Cancer, 页码:2674-2681 , 文章类型: Article,,卷期:2008年122-12]
- Platycodin D (PD), a major constituent of triterpene saponins in Platycodon grandiflorum, has also become an interesting candidate for cancer chemotherapy; however, little is known about apoptotic mechanisms on cancer ce...
- Effect of p53 codon 72 genotype on breast cancer survival depends on p53 gene status
[作者:Xu, Y; Yao, LH; Zhao, AL; Ouyang, T; Li, JF; Wang, TF; Fan, ZQ; Fan, T; Lin, BY; Lu, YY; Xie, YT,期刊:International Journal of Cancer, 页码:2761-2766 , 文章类型: Article,,卷期:2008年122-12]
- In vitro studies suggest that p53 codon 72 genotype alters the apoptotic capacity of p53 protein, with the 72 arginine (R) form of wild-type p53 harboring a greater apoptosis-inducing potential than the 72 proline (P) va...
- Two-dimensional differential gel electrophoresis/analysis of diethylnitrosamine induced rat hepatocellular carcinoma
[作者:Qi, YT; Chen, X; Chan, CY; Li, D; Yuan, CG; Yu, F; Lin, MC; Yew, DT; Kung, HF; Lai, L,期刊:International Journal of Cancer, 页码:2682-2688 , 文章类型: Article,,卷期:2008年122-12]
- Diethylnitrosamine (DEN) is a known carcinogen that can alkylate DNA molecules. In rats, DEN-induced hepatocellular carcinoma (HCC) model is well established. In this study, we used a two-dimensional differential gel ele...
- beta-ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat
[作者:Liu, JR; Sun, XR; Doug, HW; Sun, CH; Sun, WG; Chen, BQ; Song, YQ; Yang, BF,期刊:International Journal of Cancer, 页码:2689-2698 , 文章类型: Article,,卷期:2008年122-12]
- beta-Ionone demonstrates potent anticancer activity both in vitro and in vivo. We determined tumor incidence and the number of rats bearing tumors as well as cell proliferation and apoptosis in a rat mammary cancer model...
- LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
[作者:Ogino, S; Kawasaki, T; Nosho, K; Ohnishi, M; Suemoto, Y; Kirkner, GJ; Fuchs, CS,期刊:International Journal of Cancer, 页码:2767-2773 , 文章类型: Article,,卷期:2008年122-12]
- The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and BRAF mutation. Genome-wide hypomethylat...
- Protective role of 1 alpha, 25-dihydroxyvitamin D-3 against oxidative stress in nonmalignant human prostate epithelial cells
[作者:Bao, BY; Ting, HJ; Hsu, JW; Lee, YF,期刊:International Journal of Cancer, 页码:2699-2706 , 文章类型: Article,,卷期:2008年122-12]
- Overproduction of reactive oxygen species (ROS), through either endogenous or exogenous sources, could induce DNA damage, and accumulation of DNA damage might lead to multistep carcinogenesis: The antioxidative effects o...
- alpha-Galactosylceramide-loaded, antigen-expressing B cells prime a wide spectrum of antitumor immunity
[作者:Kim, YJ; Ko, HJ; Kim, YS; Kim, DH; Kang, S; Kim, JM; Chung, Y; Kang, CY,期刊:International Journal of Cancer, 页码:2774-2783 , 文章类型: Article,,卷期:2008年122-12]
- Most of the current tumor vaccines successfully elicit strong protection against tumor but offer little therapeutic effect against existing tumors, highlighting the need for a more effective vaccine strategy. Vaccination...
- Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells
[作者:Kanno, A; Satoh, K; Masamune, A; Hirota, M; Kimura, K; Umino, J; Hamada, S; Satoh, A; Egawa, S; Motoi, F; Unno, M; Shimosegawa, T,期刊:International Journal of Cancer, 页码:2707-2718 , 文章类型: Article,,卷期:2008年122-12]
- Periostin is a secretory protein that has been suggested to function as a cell adhesion molecule and promote the invasiveness or growth rate of tumors. However, little is known about the association of its expression and...
- Eradication of established renal cell carcinoma by a combination of 5-fluorouracil and anti-4-1BB monoclonal antibody in mice
[作者:Ju, SA; Cheon, SH; Park, SM; Tam, NQ; Kim, YM; An, WG; Kim, BS,期刊:International Journal of Cancer, 页码:2784-2790 , 文章类型: Article,,卷期:2008年122-12]
- Renal cell carcinoma (RCC), one of the most incurable malignancies, is highly resistant to chemotherapy and radiotherapy. Cytokine immunotherapy has been the standard approach, but the overall response rate is still very...
- HPV16 E6(29-38)-specific T cells kill cervical carcinoma cells despite partial evasion of T-cell effector function
[作者:Thomas, KJ; Smith, KL; Youde, SJ; Evans, M; Fiander, AN; Borysiewicz, LK; Man, S,期刊:International Journal of Cancer, 页码:2791-2799 , 文章类型: Article,,卷期:2008年122-12]
- Persistent human papillomavirus type 16 (HPV16) infection is associated with the development of more than 50% of cervical cancers. The HPV16 E6 and E7 oncoproteins are constitutively expressed in cervical carcinomas and ...
- Establishment, characterization and drug sensitivity testing in primary cultures of human thymoma and thymic carcinoma
[作者:Ehemann, V; Kern, MA; Breinig, M; Schnabel, PA; Gunawan, B; Schulten, HJ; Schlaeger, C; Radwimmer, B; Steger, CM; Dienemann, H; Lichter, P; Schirmacher, P; Rieker, RJ,期刊:International Journal of Cancer, 页码:2719-2725 , 文章类型: Article,,卷期:2008年122-12]
- Thymomas and thymic carcinomas are peculiar epithelial tumors of the anterior mediastinum. They may show aggressive clinical behavior and are a paradigm for the interaction between the tumor and the immune system. So far...
- Quantitative promoter methylation analysis of hepatocellular carcinoma, cirrhotic and normal liver
[作者:Harder, J; Opitz, OG; Brabender, J; Olschewski, M; Blum, HE; Nomoto, S; Usadel, H,期刊:International Journal of Cancer, 页码:2800-2804 , 文章类型: Article,,卷期:2008年122-12]
- Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Little is known about its molecular pathogenesis and the relevance of DNA methylation for disease initiation and progression. Nevertheless, prom...
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