- Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency
[作者:Yang, JL; Qu, XJ; Yu, Y; Kohn, EC; Friedlander, ML,期刊:International Journal of Cancer, 页码:258-263 , 文章类型: Article,,卷期:2008年123-2]
- We have previously reported that high-dose nifedipine had a selective antiproliferative effect on colon cancer cell lines deficient in DNA mismatch repair (MMR). We hypothesized that carboxyamidotriazole (CAI), a calcium...
- Telomeric 3 ' overhangs in chronic HBV-related hepatitis and hepatocellular carcinoma
[作者:Lee, JE; Oh, BK; Choi, J; Park, YN,期刊:International Journal of Cancer, 页码:264-272 , 文章类型: Article,,卷期:2008年123-2]
- Telomeric 3' overhang is a key component of telomere structure, but little is known about its role in hepatocarcinogenesis. We examined the 3' overhang and telomere length, mRNA levels of hTERT, POT1, TRF1 and cytokerati...
- Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in Apc(Min/+) mice
[作者:Giroux, V; Lemay, F; Bernatchez, G; Robitaille, Y; Carrier, JC,期刊:International Journal of Cancer, 页码:303-311 , 文章类型: Article,,卷期:2008年123-2]
- Clinical evidence suggests that estradiol replacement therapy reduces colon cancer risk in 'post'menopausal women. In colon epithelial cells, the estrogen receptor beta (ER beta) is the predominant ER subtype and is thou...
- Isotype-specific inhibitors of the glycolytic keyregulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation
[作者:Spoden, GA; Mazurek, S; Morandell, D; Bacher, N; Ausserlechner, MJ; Jansen-Durr, P; Eigenbrodt, E; Zwerschke, W,期刊:International Journal of Cancer, 页码:312-321 , 文章类型: Article,,卷期:2008年123-2]
- Tumor cells express the glycolytic regulator pyruvate kinase subtype M2 (M2-PK), which can occur in a tetrameric form with high affinity to its substrate phosphoenolpyruvate (PEP) and a dimeric form with a low PEP affini...
- Haplotype-specific expression of the human PDGFRA gene correlates with the risk of glioblastomas
[作者:Toepoel, M; Joosten, PHLJ; Knobbe, CB; Afink, GB; Zotz, RB; Steegers-Theunissen, RPM; Reifenberger, G; van Zoelen, EJJ,期刊:International Journal of Cancer, 页码:322-329 , 文章类型: Article,,卷期:2008年123-2]
- Aberrant expression of the platelet-derived growth factor a-receptor (PDGFRA) gene has been associated with various diseases, including neural tube defects and gliomas. We have previously identified 5 distinct haplotypes...
- Functional evidence implicating S100P in prostate cancer progression
[作者:Basu, GD; Azorsa, DO; Kiefer, JA; Rojas, AM; Tuzmen, S; Barrett, MT; Trent, JM; Kallioniemi, O; Mousses, S,期刊:International Journal of Cancer, 页码:330-339 , 文章类型: Article,,卷期:2008年123-2]
- S100P protein regulates calcium signal transduction and mediates cytoskeletal interaction, protein phosphorylation and transcriptional control. We have previously shown how elevated S100P levels in prostate cancer strong...
- Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells
[作者:Ueno, Y; Sakurai, H; Tsunoda, S; Choo, MK; Matsuo, M; Koizumi, K; Saiki, I,期刊:International Journal of Cancer, 页码:340-347 , 文章类型: Article,,卷期:2008年123-2]
- ErbB3 receptor tyrosine kinase has been shown to induce tumor progression in several types of cancer through heterodimerization with ErbB2. However, the role of ErbB3 and its ligand heregulin (HRG) in tumor metastasis re...
- HMGA2 gene is a promising target for ovarian cancer silencing therapy
[作者:Malek, A; Bakhidze, E; Noske, A; Sers, C; Aigner, A; Schafer, R; Tchernitsa, O,期刊:International Journal of Cancer, 页码:348-356 , 文章类型: Article,,卷期:2008年123-2]
- Ovarian cancer is one of the most lethal gynecological malignancies and the small success rate of routine therapeutic methods justifies efforts to develop new approaches. Evaluation of targets for effective inhibition of...
- alpha v beta 3 and alpha v beta 5 integrins control glioma cell response to ionising radiation through ILK and RhoB
[作者:Monferran, S; Skuli, N; Delmas, C; Favre, G; Bonnet, J; Cohen-Jonathan-Moyal, E; Toulas, C,期刊:International Journal of Cancer, 页码:357-364 , 文章类型: Article,,卷期:2008年123-2]
- Integrins are extracellular matrix receptors involved in tumour invasion and angiogenesis. Although there is evidence that inhibiting integrins might enhance the efficiency of radiotherapy, little is known about the exac...
- Silencing of hSlo potassium channels in human osteosarcoma cells promotes tumorigenesis
[作者:Cambien, B; Rezzonico, R; Vitale, S; Rouzaire-Dubois, B; Dubois, JM; Barthel, R; Soilihi, BK; Mograbi, B; Schmid-Alliana, A; Schmid-Antomarchi, H,期刊:International Journal of Cancer, 页码:365-371 , 文章类型: Article,,卷期:2008年123-2]
- Potassium channels, the most diverse superfamily of ion channels, have recently emerged as regulators of carcinogenesis, thus introducing possible new therapeutic strategies in the fight against cancer. In particular, th...
- Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis
[作者:Li, CG; Gruidl, M; Eschrich, S; McCarthy, S; Wang, HG; Alexandrow, MG; Yeatman, TJ,期刊:International Journal of Cancer, 页码:273-282 , 文章类型: Article,,卷期:2008年123-2]
- Insulin-induced gene 2 (Insig2) was recently identified as a putative positive prognostic biomarker for colon cancer prognosis. Insig2 has been previously reported to be an endoplasmic reticulum (ER) membrane protein, an...
- DNA repair deficiency leads to susceptibility to develop arsenic-induced premalignant skin lesions
[作者:Banerjee, M; Sarma, N; Biswas, R; Roy, J; Mukherjee, A; Giri, AK,期刊:International Journal of Cancer, 页码:283-287 , 文章类型: Article,,卷期:2008年123-2]
- In West Bengal, India, although more than 6 million people are exposed to arsenic through drinking water, only 15-20% showed arsenic-induced skin lesions, including premalignant hyperkeratosis. This indicates toward some...
- Dietary prevention of malignant glioma aggressiveness, implications in oxidant stress and apoptosis
[作者:Pouliquen, D; Olivier, C; Hervouet, E; Pedelaborde, F; Debien, E; Le Cabellec, MT; Gratas, C; Homma, T; Meflah, K; Vallette, FM; Menanteau, J,期刊:International Journal of Cancer, 页码:288-295 , 文章类型: Article,,卷期:2008年123-2]
- Our study explored the influence of diet on gliomagenesis and associated systemic effects (SE) in rats. The experimental diet contained various ingredients supposed to interfere with carcinogenesis, mainly phytochemicals...
- Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis
[作者:Liao, XY; Siu, MKY; Chan, KYK; Wong, ESY; Ngan, HYS; Chan, QKY; Li, ASM; Khoo, US; Cheung, ANY,期刊:International Journal of Cancer, 页码:296-302 , 文章类型: Article,,卷期:2008年123-2]
- Epigenetic aberration is known to be important in human carcinogenesis. Promoter methylation status of RAS effector related genes, RASSF1A, RASSF2A, hDAB2IP (m2a and m2b regions) and BLU, was evaluated in 76 endometrial ...
- Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling
[作者:Wong, TS; Liu, XB; Ho, ACW; Yuen, APW; Ng, RWM; Wei, WI,期刊:International Journal of Cancer, 页码:251-257 , 文章类型: Article,,卷期:2008年123-2]
- MicroRNAs (miRNAs) are noncoding RNAs with specific regulatory role in gene expression. Recent reports suggested their involvement in human malignancies. Currently, there is no information concerning miRNA expression and...
- Tumoricidal activity of high-dose tumor necrosis factor-alpha is mediated by macrophage-derived nitric oxide burst and permanent blood flow shutdown
[作者:Menon, C; Bauer, TW; Kelley, ST; Raz, DJ; Bleier, JI; Patel, K; Steele, K; Prabakaran, I; Shifrin, A; Buerk, DG; Sehgal, CM; Fraker, DL,期刊:International Journal of Cancer, 页码:464-475 , 文章类型: Article,,卷期:2008年123-2]
- This study investigates the role of tumor nitric oxide (NO) and vascular regulation in tumor ulceration following high-dose tumor necrosis factor-alpha (TNF) treatment. Using TNF-responsive (MethA) and nonresponsive (LL2...
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