- Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype
[作者:Butterworth, KT; McCarthy, HO; Devlin, A; Ming, L; Robson, T; McKeown, SR; Worthington, J,期刊:International Journal of Cancer, 页码:760-768 , 文章类型: Article,,卷期:2008年123-4]
- Hypoxia confers resistance to common cancer therapies, however, it has also has been shown to result in genetic alterations which may allow a survival advantage and increase the tumorigenic properties of cancer cells. Ad...
- Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival
[作者:Shabo, I; Stal, O; Olsson, H; Dore, S; Svanvik, J,期刊:International Journal of Cancer, 页码:780-786 , 文章类型: Article,,卷期:2008年123-4]
- Cells of the monocyte/macrophage lineage are important for tumour cell migration, invasion and metastasis. Fusion between macrophages and cancer cells in animal models in vitro and in vivo causes hybrids with increased m...
- Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival
[作者:Shono, T; Yokoyama, N; Uesaka, T; Kuroda, J; Takeya, R; Yamasaki, T; Amano, T; Mizoguchi, M; Suzuki, SO; Niiro, H; Miyamoto, K; Akashi, K; Iwaki, T; Sumimoto, H; Sasaki, T,期刊:International Journal of Cancer, 页码:787-792 , 文章类型: Article,,卷期:2008年123-4]
- Reactive oxygen species (ROS) have been attracting attention as mediators of various cell-signaling pathways. Nox-family NADPH oxidases have proven to be a major source of ROS production in various cell types and have cr...
- KIT overexpression induces proliferation in astrocytes in an imatinib-responsive manner and associates with proliferation index in gliomas
[作者:Blom, T; Fox, H; Angers-Loustau, A; Peltonen, K; Kerosu, L; Wartiovaara, K; Linja, M; Janne, OA; Kovanen, P; Haapasalo, H; Nupponen, NN,期刊:International Journal of Cancer, 页码:793-800 , 文章类型: Article,,卷期:2008年123-4]
- Activating gene mutations, gene amplifications and overexpressed proteins may be useful as targets for novel therapies. Alterations at chromosome locus 4q12 are associated with gliomas and the region harbors the receptor...
- Lysophosphatidic. acid induces ovarian cancer cell dispersal by activating Fyn kinase associated with p120-catenin
[作者:Huang, RYJ; Wang, SM; Hsieh, CY; Wu, JC,期刊:International Journal of Cancer, 页码:801-809 , 文章类型: Article,,卷期:2008年123-4]
- Lysophosphatidic acid (LPA), known as the "ovarian cancer activating factor," is a natural phospholipid involved in important biological functions, such as cell proliferation, wound healing and neurite retraction. LPA ca...
- TIP30 is associated with progression and metastasis of prostate cancer
[作者:Zhang, H; Zhang, Y; Duan, HO; Kirley, SD; Lin, SX; McDougal, WS; Xiao, H; Wu, CL,期刊:International Journal of Cancer, 页码:810-816 , 文章类型: Article,,卷期:2008年123-4]
- Tat-interacting protein 30 (TIP30), a transcriptional repressor for ER alpha-mediated transcription, possesses several characteristics of a tumor suppressor in certain human and mouse cells. It is reported that deletion ...
- Integrated gene copy number and expression microarray analysis of gastric cancer highlights potential target genes
[作者:Myllykangas, S; Junnila, S; Kokkola, A; Autio, R; Scheinin, I; Kiviluoto, T; Karjalainen-Lindsberg, ML; Hollmen, J; Knuutila, S; Puolakkainen, P; Monn, O,期刊:International Journal of Cancer, 页码:817-825 , 文章类型: Article,,卷期:2008年123-4]
- We performed an integrated array comparative genomic hybridization (aCGH) and expression microarray analysis of 8 normal gastric tissues and 38 primary tumors, including 25 intestinal and 13 diffuse gastric adenocarcinom...
- The role of PGP9.5 as a tumor suppressor gene in human cancer
[作者:Tokumaru, Y; Yamashita, K; Kim, MS; Park, HL; Osada, M; Mori, M; Sidransky, D,期刊:International Journal of Cancer, 页码:753-759 , 文章类型: Article,,卷期:2008年123-4]
- PGP9.5 is a controversial molecule from an oncologic point of view. We recently identified frequent methylation of PGP9.5 gene exclusively in primary head and neck squamous cell carcinoma (HNSCC), suggesting that it coul...
- Legume and isoflavone intake and prostate cancer risk: The multiethnic cohort study
[作者:Park, SY; Murphy, SP; Wilkens, LR; Henderson, BE; Kolonel, LN,期刊:International Journal of Cancer, 页码:927-932 , 文章类型: Article,,卷期:2008年123-4]
- Findings from studies of legume, soy and isoflavone intake and prostate cancer risk are as yet inconclusive, although soy has received considerable attention due to its high phytoestrogen content. Therefore, the present ...
- Risk of different histological types of postmenopausal breast cancer by type and regimen of menopausal hormone therapy
[作者:Fiesch-Janys, D; Slanger, T; Mutschelknauss, E; Kropp, S; Obi, N; Vettorazzi, E; Braendle, W; Bastert, G; Hentschel, S; Berger, J; Chang-Claude, J,期刊:International Journal of Cancer, 页码:933-941 , 文章类型: Article,,卷期:2008年123-4]
- In a large population-based case-control study in Germany, including 3,464 breast cancer cases aged 50-74 at diagnosis and 6,657 population based and frequency matched controls, we investigated the effects of menopausal ...
- A hybrid protein comprising ATF domain of pro-UK and VAS, an angiogenesis inhibitor, is a potent candidate for targeted cancer therapy
[作者:Sun, QM; Xu, QN; Dong, XB; Cao, L; Huang, XF; Hu, QG; Hua, ZC,期刊:International Journal of Cancer, 页码:942-950 , 文章类型: Article,,卷期:2008年123-4]
- Directional and controllable degradation of extracellular matrix mediated by the uPA-uPA receptor (uPAR) system is ubiquitously implicated in tumor establishment, invasion and metastasis. Targeting the excessive activati...
- Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice
[作者:Cho, SJ; Kim, JS; Kim, JM; Lee, JY; Jung, HC; Song, IS,期刊:International Journal of Cancer, 页码:951-957 , 文章类型: Article,,卷期:2008年123-4]
- Statins, HMG-CoA reductase inhibitors could be associated with the risk reduction of colorectal cancer. We previously demonstrated that simvastatin inhibits NF-kappa B signaling in human intestinal epithelia] cells and a...
- TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and invasion in pancreatic cancer
[作者:Wang, ZW; Song, W; Aboukameel, A; Mohammad, M; Wang, GP; Banerjee, S; Kong, D; Wang, SM; Sarkar, FH; Mohammad, RM,期刊:International Journal of Cancer, 页码:958-966 , 文章类型: Article,,卷期:2008年123-4]
- Bcl-2 family of proteins plays critical roles in human cancers, including pancreatic cancer, suggesting that the discovery of specific agents targeting Bcl-2 family proteins would be extremely valuable for pancreatic can...
- Upregulation of miR-23a similar to 27a similar to 24 decreases transforming growth factor-beta-induced tumor-suppressive activities in human hepatocellular carcinoma cells
[作者:Huang, SL; He, XH; Ding, J; Liang, LH; Zhao, YJ; Zhang, ZF; Yao, X; Pan, ZM; Zhang, PP; Li, JJ; Wan, DF; Gu, JR,期刊:International Journal of Cancer, 页码:972-978 , 文章类型: Article,,卷期:2008年123-4]
- Transforming growth factor-beta (TGF-beta) plays a dual and complex role in human cancer. In this report, we observe a specific set of MicroRNAs (miRNAs) changed in response to TGF-beta in human hepatocellular carcinoma ...
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