- EGFR genetic heterogeneity of nonsmall cell lung cancers contributing to acquired gefitinib resistance
[作者:Jiang, SX; Yamashita, K; Yamamoto, M; Piao, CJ; Umezawa, A; Saegusa, M; Yoshida, T; Katagiri, M; Masuda, N; Hayakawa, K; Okayasu, I,期刊:International Journal of Cancer, 页码:2480-2486 , 文章类型: Article,,卷期:2008年123-11]
- Gefitinib is dramatically effective for nonsmall cell lung cancers (NSCLCs) with activating mutations of the epidermal growth factor receptor (EGFR) gene, but these tumors eventually develop drug resistance, attributable...
- Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis
[作者:Ghosh, S; Ghosh, A; Maiti, GP; Alam, N; Roy, A; Roy, B; Roychoudhary, S; Panda, CK,期刊:International Journal of Cancer, 页码:2594-2604 , 文章类型: Article,,卷期:2008年123-11]
- The aim of our study, was to analyze the alterations of some candidate tumor suppressor genes (TSGs) viz. LIMD1, LTF. CDC25A, SCOTIN, RASSFIA anti CACNA2D2 located in the chromosomal region 3p21.31 associated with the de...
- Transcriptional profiling identifies an interferon-associated host immune response in invasive squamous cell carcinoma of the skin
[作者:Wenzel, J; Tomiuk, S; Zahn, S; Kisters, D; Vahsen, A; Wiechert, A; Mikus, S; Birth, M; Scheler, M; von Bubnoff, D; Baron, JM; Merk, HF; Mauch, C; Krieg, T; Bieber, T; Bosio, A; Hofmann, K; Tuting, T; Peters, B,期刊:International Journal of Cancer, 页码:2605-2615 , 文章类型: Article,,卷期:2008年123-11]
- Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) represent the 2 most common types of nonmelanoma skin cancer. Both derive from keratinocytes but show a distinct biological behavior. Here we present transcrip...
- Risk of cervical cancer among immigrants by age at immigration and follow-up time in Sweden, from 1968 to 2004
[作者:Azerkan, F; Zendehdel, K; Tillgren, P; Faxelid, E; Sparen, P,期刊:International Journal of Cancer, 页码:2664-2670 , 文章类型: Article,,卷期:2008年123-11]
- Because of great variation in the prevalence of human papilloma virus infection and other risk factors of cervical cancer worldwide, migrant studies may help further the understanding of the aetiology all improve prevent...
- Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38
[作者:Sauvant, C; Nowak, M; Wirth, C; Schneider, B; Riemann, A; Gekle, M; Thews, O,期刊:International Journal of Cancer, 页码:2532-2542 , 文章类型: Article,,卷期:2008年123-11]
- Because solid growing tumors often show hypoxia and pronounced extracellular acidosis, the aim of this study was to analyze the impact of an acidotic environment on the activity of the p-glycoprotein (pGP) and on the cel...
- HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL
[作者:Harao, M; Hirata, S; Irie, A; Senju, S; Nakatsura, T; Komori, H; Ikuta, Y; Yokomine, K; Imai, K; Inoue, M; Harada, K; Mori, T; Tsunoda, T; Nakatsuru, S; Daigo, Y; Nomori, H; Nakamura, Y; Baba, H; Nishimura, Y,期刊:International Journal of Cancer, 页码:2616-2625 , 文章类型: Article,,卷期:2008年123-11]
- Toward the development of a novel cancer immunotherapy, we have previously identified several tumor-associated antigens (TAAs) and the epitopes recognized by human histocompatibility leukocyte (HLA)-A2/A24-restricted cyt...
- A population-based analysis of 788 cases of yolk sac tumors: A comparison of males and females
[作者:Shah, JP; Kumar, S; Bryant, CS; Ali-Fehmi, R; Malone, JM; Deppe, G; Morris, RT,期刊:International Journal of Cancer, 页码:2671-2675 , 文章类型: Article,,卷期:2008年123-11]
- Yolk sac tumors (YST) are it rare and aggressive germ Cell tumor. The objective of this study is to compare the patient characteristics and survival of YST lit males and females. Demographic and clinicopathologic informa...
- Original triazine inductor of new specific molecular targets, with antitumor activity against nonsmall cell lung cancer
[作者:Moreau, D; Jacquot, C; Tsita, P; Chinou, I; Tomasoni, C; Juge, M; Antoniadou-Vyza, E; Martignat, L; Pineau, A; Roussakis, C,期刊:International Journal of Cancer, 页码:2676-2683 , 文章类型: Article,,卷期:2008年123-11]
- Despite our growing insight into carcinogenesis, treatment of tumors, especially nonsmall cell lung cancer (NSCLC), remains limited and it is urgent to develop strategies that target tumor cells and their genetic feature...
- Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model
[作者:Carvalho, MA; Zecchin, KG; Seguin, F; Bastos, DC; Agostini, M; Rangel, ALCA; Veiga, SS; Raposo, HF; Oliveira, HCF; Loda, M; Coletta, RD; Graner, E,期刊:International Journal of Cancer, 页码:2557-2565 , 文章类型: Article,,卷期:2008年123-11]
- Fatty acid synthase (FASN) is the enzyme responsible for the endogenous synthesis of the saturated fatty, acid palmitate. In contrast to most normal cells. malignant cells depend on FASN activity for growth and survival....
- Heparanase induces VEGF C and facilitates tumor lymphangiogenesis
[作者:Cohen-Kaplan, V; Naroditsky, I; Zetser, A; Illan, N; Vlodavsky, I; Doweck, I,期刊:International Journal of Cancer, 页码:2566-2573 , 文章类型: Article,,卷期:2008年123-11]
- Heparanase is an endoglycosidase that specifically cleaves heparan sulfate side chains, a class of glycosaminoglycans abundantly present in the extracellular matrix and on the cell surface. Heparanase activity is strongl...
- Characterization of humoral immune responses against p16, p53, HPV16 E6 and HPV16 E7 in patients with HPV-associated cancers
[作者:Reuschenbach, M; Waterboer, T; Wallin, KL; Einenkel, J; Dillner, J; Hamsikova, E; Eschenbach, D; Zimmer, H; Heilig, B; Kupitz, J; Pawlita, M; Doeberitz, MV; Wentzensen, N,期刊:International Journal of Cancer, 页码:2626-2631 , 文章类型: Article,,卷期:2008年123-11]
- The cellular tumor suppressor p16 is strongly overexpressed in cervical cancers and precancers. We have previously demonstrated that infiltrating T lymphocytes reactive against p16 can be found in cervical cancer patient...
- The resveratrol analogue 3,5,3 ',4 ',5 '- pentahydroxy-trans-stilbene inhibits cell transformation via MEK
[作者:Lee, KW; Kang, NJ; Rogozin, EA; Oh, SM; Heo, YS; Pugliese, A; Bode, AM; Lee, HJ; Dong, ZG,期刊:International Journal of Cancer, 页码:2487-2496 , 文章类型: Article,,卷期:2008年123-11]
- Resveratrol. present in grapes and red wine, is reported to be a natural chemopreventive agent against cancer. However, the concentrations required to exert these effects may be difficult to achieve by drinking only 1 or...
- Preneoplastic and neoplastic lesions in the lung, liver and urinary tract of mice exposed to environmental cigarette smoke and UV light since birth
[作者:D'Agostini, F; Balansky, R; Steele, VE; Ganchev, G; Pesce, C; De Flora, S,期刊:International Journal of Cancer, 页码:2497-2502 , 文章类型: Article,,卷期:2008年123-11]
- It is difficult to reproduce the carcinogenicity of cigarette smoke (CS) in animal models. Recently. we showed that exposure or mice to mainstream CS (MCS) For 120 days, starting immediately after birth. resulted in an e...
- Poly morph isms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population
[作者:Ma, ZY; Tsuchiya, N; Yuasa, T; Inoue, T; Kumazawa, T; Narita, S; Horikawa, Y; Tsuruta, H; Obara, T; Saito, M; Satoh, S; Ogawa, O; Habuchi, T,期刊:International Journal of Cancer, 页码:2574-2579 , 文章类型: Article,,卷期:2008年123-11]
- Fibroblast growth factor receptor 4 (FGFR4) is a member of a family of transmembrane receptors with ligand-induced tyrosine kinase activity. The Glycine (Gly) to Arginine (Arg) polymorphism at codon 388 (Gly388Arg), whic...
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