- Early aberrant insulin-like growth factor signaling in the progression to endometrial carcinoma is augmented by tamoxifen
[作者:Strissel, PL; Ellmann, S; Loprich, E; Thiel, F; Fasching, PA; Stiegler, E; Hartmann, A; Beckmann, MW; Strick, R,期刊:International Journal of Cancer, 页码:2871-2879 , 文章类型: Article,,卷期:2008年123-12]
- Tamoxifen is an important selective estrogen receptor (ER) modulator for treatment of steroid hormone positive breast cancer. In addition to the beneficial effect, tamoxifen is one risk factor for endometrial carcinoma (...
- A panel of p16(INK4A), MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma
[作者:Hoevenaars, BM; van der Avoort, IAM; de Wilde, PCM; Massuger, LFAG; Melchers, WJG; de Hullu, JA; Bulten, J,期刊:International Journal of Cancer, 页码:2767-2773 , 文章类型: Article,,卷期:2008年123-12]
- Two pathways leading to vulvar squarnous cell carcinoma (SCC) exist. The expression of proliferation- and cell-cycle-related biomarkers and the presence of high-risk (hr) HPV might be helpful to distinguish the premalign...
- Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer
[作者:Bjorkman, M; Iljin, K; Halonen, P; Sara, H; Kaivanto, E; Nees, M; Kallioniemi, OP,期刊:International Journal of Cancer, 页码:2774-2781 , 文章类型: Article,,卷期:2008年123-12]
- TMPRSS2 gene and oncogenic ETS factors, such as ERG, occur in up to 50% of all prostate cancers. We recently defined a gene signature that was characteristic to prostate cancers with ERG activation. This suggested epigen...
- Leptin regulation of proangiogenic molecules in benign and cancerous endometrial cells
[作者:Carino, C; Olawaiye, AB; Cherfils, S; Serikawa, T; Lynch, MP; Rueda, BR; Gonzalez, RR,期刊:International Journal of Cancer, 页码:2782-2790 , 文章类型: Article,,卷期:2008年123-12]
- Several proangiogenic/proinflammatory factors involved in endometrial cancer are regulated by leptin, but the signaling mechanisms responsible for these leptin-induced actions are largely unknown. Here, we report that in...
- MicroRNA alterations in head and neck squamous cell carcinomal
[作者:Chang, SS; Jiang, WW; Smith, I; Poeta, LM; Begum, S; Glazer, C; Shan, S; Westra, W; Sidransky, D; Califano, JA,期刊:International Journal of Cancer, 页码:2791-2797 , 文章类型: Article,,卷期:2008年123-12]
- MicroRNAs (mirs) are small noncoding RNA molecules (similar to 22 nocleotides) that regulate posttranscriptional gene expression. Currently, there has not been a comprehensive study of their role in primary head and neck...
- Relationship of SNCG, S100A4, S100A9 and LCN2 gene expression and DNA methylation in bladder cancer
[作者:Dokun, OY; Florl, AR; Seifert, HH; Wolff, I; Schulz, WA,期刊:International Journal of Cancer, 页码:2798-2807 , 文章类型: Article,,卷期:2008年123-12]
- Microarray analysis of paired cultures of normal and cancerous urothelial cells revealed differences in cytokeratin and adhesion gene expression. Normal cells expressed autocrine growth factor genes more strongly whereas...
- Clinical implication of recurrent copy number alterations in hepatocellular carcinoma and putative oncogenes in recurrent gains on 1q
[作者:Kim, TM; Yim, SH; Shin, SH; Xu, HD; Jung, YC; Park, CK; Choi, JY; Park, WS; Kwon, MS; Fiegler, H; Carter, NP; Rhyu, MG; Chung, YJ,期刊:International Journal of Cancer, 页码:2808-2815 , 文章类型: Article,,卷期:2008年123-12]
- To elucidate the pathogenesis of hepatocellular carcinoma (HCC) and develop useful prognosis predictors, it is necessary to identify biologically relevant genomic alterations in HCC. In our study, we defined recurrently ...
- Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression
[作者:Morisawa, T; Marusawa, H; Ueda, Y; Iwai, A; Okazaki, I; Honjo, T; Chiba, T,期刊:International Journal of Cancer, 页码:2735-2740 , 文章类型: Article,,卷期:2008年123-12]
- Various molecular changes characterizing organ-specific carcinogenesis have been identified in human tumors; however, the molecular mechanisms of the genomic changes specific for each cancer are not well defined. A trans...
- Absence of ESR1 amplification in a series of breast cancers
[作者:Adelaide, J; Finetti, P; Charafe-Jauffret, E; Wicinski, J; Jacquemier, J; Sotiriou, C; Bertucci, F; Birnbaum, D; Chaffanet, M,期刊:International Journal of Cancer, 页码:2970-2972 , 文章类型: Letter,,卷期:2008年123-12]
-
- Refining the evidence for GSTA1 and eNOS genetic effects on risk of radiotherapy-induced telangiectasia
[作者:Giotopoulos, G; Armstrong, C; Osman, A; Peat, I; Symonds, RP; Talbot, CJ,期刊:International Journal of Cancer, 页码:2973-2974 , 文章类型: Letter,,卷期:2008年123-12]
-
- 15-Lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity
[作者:Zhu, H; Glasgow, W; George, MD; Chrysovergis, K; Olden, K; Roberts, JD; Eling, T,期刊:International Journal of Cancer, 页码:2741-2749 , 文章类型: Article,,卷期:2008年123-12]
- 15-LOX-1 and its metabolites are involved in colorectal cancer. Recently, we reported that 15-LOX-1 overexpression in HCT-116 human colorectal cancer cells inhibited cell growth by induction of p53 phosphorylation (4). T...
- Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: Comparison with silymarin and silibinin
[作者:Deep, G; Raina, K; Singh, RP; Oberlies, NH; Kroll, DJ; Agarwal, R,期刊:International Journal of Cancer, 页码:2750-2758 , 文章类型: Article,,卷期:2008年123-12]
- Earlier studies have shown the cancer chemopreventive efficacy of silymarin and its semi-purified constituent silibinin against prostate cancer (PCa), but the efficacy of other constituents of silymarin is largely unknow...
- Bone marrow stroma cells regulate TIEG1 expression in acute lymphoblastic leukemia cells: Role of TGF beta/BMP-6 and TIEG1 in chemotherapy escape
[作者:Dosen-Dahl, G; Munthe, E; Nygren, MK; Stubberud, H; Hystad, ME; Rian, E,期刊:International Journal of Cancer, 页码:2759-2766 , 文章类型: Article,,卷期:2008年123-12]
- The bone marrow microenvironment regulates early B lymphopoiesis and protects leukemia cells against chemotherapy treatment, thus the microenvironment may serve as a sanctuary site for these cells. Yet, few factors that ...
- Identification of an invasion and tumor-suppressing gene, Endoglin (ENG), silenced by both epigenetic inactivation and allelic loss in esophageal squamous cell carcinoma
[作者:Wong, VCL; Chan, PL; Bernabeu, C; Law, S; Wang, LD; Li, JL; Tsao, SW; Srivastava, G; Lung, ML,期刊:International Journal of Cancer, 页码:2816-2823 , 文章类型: Article,,卷期:2008年123-12]
- Endoglin (ENG) has been identified as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma (ESCC). Earlier microcell-mediated chromosome transfer (MMCT) studies of chromosome 9 in ESCC narrowed down a ...
- Chemoresistant tumor cell lines display altered epidermal growth factor receptor and HER3 signaling and enhanced sensitivity to gefitinib
[作者:Servidei, T; Riccardi, A; Mozzetti, S; Ferlini, C; Riccardi, R,期刊:International Journal of Cancer, 页码:2939-2949 , 文章类型: Article,,卷期:2008年123-12]
- Deregulated signaling through the epidermal growth factor receptor (EGFR) is involved in chemoresistance. To identify the molecular determinants of sensitivity to the EGFR inhibitor gefitinib (Iressa, ZD1839) in chemores...
- Risk of prostate, breast and colorectal cancer after skin cancer diagnosis
[作者:Levi, F; Randimbison, L; Te, VC; Conconi, MM; La Vecchia, C,期刊:International Journal of Cancer, 页码:2899-2901 , 文章类型: Article,,卷期:2008年123-12]
- Ultraviolet radiation is the major cause of skin cancer, but promotes vitamin D synthesis, and vitamin D has been inversely related to the risk of several common cancers including prostate, breast and colorectum. We ther...
|