- Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains
[作者:Pigott, CR; Mikolajek, H; Moore, CE; Finn, SJ; Phippen, CW; Werner, JM; Proud, CG,期刊:Biochemical Journal, 页码:105-118 , 文章类型: Article,,卷期:2012年442-1]
- eEF2K (eukaryotic elongation factor 2 kinase) is a Ca2+/CaM (calmodulin)-dependent protein kinase which regulates the translation elongation machinery. eEF2K belongs to the small group of so-called 'alpha-kinases' which ...
- Induction of group IVC phospholipase A(2) in allergic asthma: transcriptional regulation by TNF alpha in bronchoepithelial cells
[作者:Bickford, JS; Newsom, KJ; Herlihy, JD; Mueller, C; Keeler, B; Qiu, XL; Walters, JN; Su, N; Wallet, SM; Flotte, TR; Nick, HS,期刊:Biochemical Journal, 页码:127-137 , 文章类型: Article,,卷期:2012年442-1]
- Airway inflammation in allergen-induced asthma is associated with eicosanoid release. These bioactive lipids exhibit anti-and pro-inflammatory activities with relevance to pulmonary pathophysiology. We hypothesized that ...
- CaMKII-gamma mediates phosphorylation of BAD at Ser(170) to regulate cytokine-dependent survival and proliferation
[作者:Hojabrpour, P; Waissbluth, I; Ghaffari, M; Cox, ME; Duronio, V,期刊:Biochemical Journal, 页码:139-149 , 文章类型: Article,,卷期:2012年442-1]
- Phosphorylation of the BH3 (Bcl-2 homology domain 3)-only protein BAD (Bcl-2/Bcl-X-L-antagonist, causing cell death) can either directly disrupt its association with the pro-survival proteins Bcl-X-L and/or Bcl-2, or cau...
- Both p110 alpha and p110 beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
[作者:Berenjeno, IM; Guillermet-Guibert, J; Pearce, W; Gray, A; Fleming, S; Vanhaesebroeck, B,期刊:Biochemical Journal, 页码:151-159 , 文章类型: Article,,卷期:2012年442-1]
- The PI3K (phosphoinositide 3-kinase) pathway is commonly activated in cancer as a consequence of inactivation of the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10), a major negative re...
- Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo
[作者:Smith, GC; Ong, WK; Rewcastle, GW; Kendall, JD; Han, WP; Shepherd, PR,期刊:Biochemical Journal, 页码:161-169 , 文章类型: Article,,卷期:2012年442-1]
- In in vitro studies class-I PI3Ks (phosphoinositide 3-kinases), class-II PI3Ks and mTOR (mammalian target of rapamycin) have all been described as having roles in the regulation of glucose metabolism. The relative role e...
- Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1
[作者:Kumano-Kuramochi, M; Shimozu, Y; Wakita, C; Ohnishi-Kameyama, M; Shibata, T; Matsunaga, S; Takano-Ishikawa, Y; Watanabe, J; Goto, M; Xie, Q; Komba, S; Uchida, K; Machida, S,期刊:Biochemical Journal, 页码:171-180 , 文章类型: Article,,卷期:2012年442-1]
- LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1) is an endothelial scavenger receptor that is important for the uptake of OxLDL (oxidized low-density lipoprotein) and contributes to the pathogenesis of ath...
- Cytochrome c-mediated formation of S-nitrosothiol in cells
[作者:Broniowska, KA; Keszler, A; Basu, S; Kim-Shapiro, DB; Hogg, N,期刊:Biochemical Journal, 页码:191-197 , 文章类型: Article,,卷期:2012年442-1]
- S-nitrosothiols are products of nitric oxide (NO) metabolism that have been implicated in a plethora of signalling processes. However, mechanisms of S-nitrosothiol formation in biological systems are uncertain, and no ef...
- Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells
[作者:Origanti, S; Nowotarski, SL; Carr, TD; Sass-Kuhn, S; Xiao, L; Wang, JY; Shantz, LM,期刊:Biochemical Journal, 页码:199-207 , 文章类型: Article,,卷期:2012年442-1]
- Upon Ras activation, ODC (ornithine decarboxylase) is markedly induced, and numerous studies suggest that ODC expression is controlled by Ras effector pathways. ODC is therefore a potential target in the treatment and pr...
- Abnormal actin binding of aberrant beta-tropomyosins is a molecular cause of muscle weakness in TPM2-related nemaline and cap myopathy
[作者:Marttila, M; Lemola, E; Wallefeld, W; Memo, M; Donner, K; Laing, NG; Marston, S; Gronholm, M; Wallgren-Pettersson, C,期刊:Biochemical Journal, 页码:231-239 , 文章类型: Article,,卷期:2012年442-1]
- NM (nemaline myopathy) is a rare genetic muscle disorder defined on the basis of muscle weakness and the presence of structural abnormalities in the muscle fibres, i.e. nemaline bodies. The related disorder cap myopathy ...
- New insights into the structure of the reaction centre from Blastochloris viridis: evolution in the laboratory
[作者:Roszak, AW; Moulisova, V; Reksodipuro, ADP; Gardiner, AT; Fujii, R; Hashimoto, H; Isaacs, NW; Cogdell, RJ,期刊:Biochemical Journal, 页码:27-37 , 文章类型: Article,,卷期:2012年442-1]
- Newly determined crystal structures of the photosynthetic RC (reaction centre) from two substrains of the non-sulfur purple bacterium Blastochloris viridis strain DSM 133, together with analysis of their gene sequences, ...
- Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington's disease
[作者:Rush, DB; Leon, RT; McCollum, MH; Treu, RW; Wei, JN,期刊:Biochemical Journal, 页码:39-48 , 文章类型: Article,,卷期:2012年442-1]
- HD (Huntington's disease) is caused by an expanded polyQ (polyglutamine) repeat in the htt (huntingtin protein). GABAergic medium spiny neurons in the striatum are mostly affected in HD. However, mhtt (mutant huntingtin)...
|