- The 2011 Tohoku-Oki Earthquake: Displacement Reaching the Trench Axis
[作者:Fujiwara, T; Kodaira, S; No, T; Kaiho, Y; Takahashi, N; Kaneda, Y,期刊:Science, 页码:1240-1240 , 文章类型: Article,,卷期:2011年334-6060]
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- Functional Links Between A beta Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast
[作者:Treusch, S; Hamamichi, S; Goodman, JL; Matlack, KES; Chung, CY; Baru, V; Shulman, JM; Parrado, A; Bevis, BJ; Valastyan, JS; Han, H; Lindhagen-Persson, M; Reiman, EM; Evans, DA; Bennett, DA; Olofsson, A; DeJager, PL; Tanzi, RE; Caldwell, KA; Caldwell, GA; Lindquist, S,期刊:Science, 页码:1241-1245 , 文章类型: Article,,卷期:2011年334-6060]
- A beta (beta-amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled A beta toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide screen for toxicity modifiers id...
- Detection of Pristine Gas Two Billion Years After the Big Bang
[作者:Fumagalli, M; O'Meara, JM; Prochaska, JX,期刊:Science, 页码:1245-1249 , 文章类型: Article,,卷期:2011年334-6060]
- In the current cosmological model, only the three lightest elements were created in the first few minutes after the Big Bang; all other elements were produced later in stars. To date, however, heavy elements have been ob...
- Entangling Macroscopic Diamonds at Room Temperature
[作者:Lee, KC; Sprague, MR; Sussman, BJ; Nunn, J; Langford, NK; Jin, XM; Champion, T; Michelberger, P; Reim, KF; England, D; Jaksch, D; Walmsley, IA,期刊:Science, 页码:1253-1256 , 文章类型: Article,,卷期:2011年334-6060]
- Quantum entanglement in the motion of macroscopic solid bodies has implications both for quantum technologies and foundational studies of the boundary between the quantum and classical worlds. Entanglement is usually fra...
- Enhancing Hydrogen Evolution Activity in Water Splitting by Tailoring Li+-Ni(OH)(2)-Pt Interfaces
[作者:Subbaraman, R; Tripkovic, D; Strmcnik, D; Chang, KC; Uchimura, M; Paulikas, AP; Stamenkovic, V; Markovic, NM,期刊:Science, 页码:1256-1260 , 文章类型: Article,,卷期:2011年334-6060]
- Improving the sluggish kinetics for the electrochemical reduction of water to molecular hydrogen in alkaline environments is one key to reducing the high overpotentials and associated energy losses in water-alkali and ch...
- The Role of Carbon Dioxide During the Onset of Antarctic Glaciation
[作者:Pagani, M; Huber, M; Liu, ZH; Bohaty, SM; Henderiks, J; Sijp, W; Krishnan, S; DeConto, RM,期刊:Science, 页码:1261-1264 , 文章类型: Article,,卷期:2011年334-6060]
- Earth's modern climate, characterized by polar ice sheets and large equator-to-pole temperature gradients, is rooted in environmental changes that promoted Antarctic glaciation similar to 33.7 million years ago. Onset of...
- Interhemispheric Ice-Sheet Synchronicity During the Last Glacial Maximum
[作者:Weber, ME; Clark, PU; Ricken, W; Mitrovica, JX; Hostetler, SW; Kuhn, G,期刊:Science, 页码:1265-1269 , 文章类型: Article,,卷期:2011年334-6060]
- The timing of the last maximum extent of the Antarctic ice sheets relative to those in the Northern Hemisphere remains poorly understood. We develop a chronology for the Weddell Sea sector of the East Antarctic Ice Sheet...
- Modeling Effects of Environmental Change on Wolf Population Dynamics, Trait Evolution, and Life History
[作者:Coulson, T; MacNulty, DR; Stahler, DR; Vonholdt, B; Wayne, RK; Smith, DW,期刊:Science, 页码:1275-1278 , 文章类型: Article,,卷期:2011年334-6060]
- Environmental change has been observed to generate simultaneous responses in population dynamics, life history, gene frequencies, and morphology in a number of species. But how common are such eco-evolutionary responses ...
- Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
[作者:Anastasiou, D; Poulogiannis, G; Asara, JM; Boxer, MB; Jiang, JK; Shen, M; Bellinger, G; Sasaki, AT; Locasale, JW; Auld, DS; Thomas, CJ; Vander Heiden, MG; Cantley, LC,期刊:Science, 页码:1278-1283 , 文章类型: Article,,卷期:2011年334-6060]
- Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer cell survival. We show that, in human lung cancer cells, acute increases in intracellular concentrations of ROS caused inhibiti...
- Hemoglobins S and C Interfere with Actin Remodeling in Plasmodium falciparum-Infected Erythrocytes
[作者:Cyrklaff, M; Sanchez, CP; Kilian, N; Bisseye, C; Simpore, J; Frischknecht, F; Lanzer, M,期刊:Science, 页码:1283-1286 , 文章类型: Article,,卷期:2011年334-6060]
- The hemoglobins S and C protect carriers from severe Plasmodium falciparum malaria. Here, we found that these hemoglobinopathies affected the trafficking system that directs parasite-encoded proteins to the surface of in...
- Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design
[作者:Diskin, R; Scheid, JF; Marcovecchio, PM; West, AP; Klein, F; Gao, H; Gnanapragasam, PNP; Abadir, A; Seaman, MS; Nussenzweig, MC; Bjorkman, PJ,期刊:Science, 页码:1289-1293 , 文章类型: Article,,卷期:2011年334-6060]
- Antibodies against the CD4 binding site (CD4bs) on the HIV-1 spike protein gp120 can show exceptional potency and breadth. We determined structures of NIH45-46, a more potent clonal variant of VRC01, alone and bound to g...
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